Peptides DB

Research-centric peptide and protocol reference hub

Best Peptides for Metabolic

NAD+, MOTS-c, SS-31 (Elamipretide), AICAR, BAM-15, L-Carnitine, GLP-1 agonists (Semaglutide, Tirzepatide), and SLU-PP-332 are the peptides most-studied for metabolic health — glucose regulation, mitochondrial function, lipid handling, and energy production. Each entry below links to its full research profile.

Ranked by approved-study count. 6 peptides in this category.

SemaglutideFDA Approved

GLP-1 Receptor Agonist | Weight Loss & Diabetes

### Semaglutide Summary Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that has been investigated for its role in managing type 2 diabetes and obesity. Its efficacy in promoting weight loss and improving glycemic control has garnered significant attention in recent clinical research.

4 studiesDominant effect: metabolic
AOD-9604Well Studied

Modified hGH Fragment | Fat Loss Peptide

A GH-fragment–derived peptide primarily discussed for fat loss and body-composition change, sometimes with cartilage and joint-repair context.

4 studiesDominant effect: metabolic
SS-31Well Studied

Mitochondrial-Targeted Peptide | Cardiolipin Protector

### Summary SS-31, also known as Elamipretide, is a peptide that has garnered attention for its potential role in mitochondrial protection and its implications in various health conditions, particularly those involving oxidative stress and mitochondrial dysfunction.

4 studies
MOTS-CWell Studied

Mitochondrial-Derived Peptide | Metabolic Regulator

### Summary MOTS-C is a mitochondrial-derived peptide that has garnered attention for its potential roles in metabolic regulation and cellular stress responses. Emerging research suggests it may have implications in various health conditions, including cardiovascular diseases and placental function.

3 studies
TirzepatideFDA Approved

Dual GIP/GLP-1 Receptor Agonist | Weight Loss & Diabetes

### Summary Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that has been investigated for its potential in managing type 2 diabetes and obesity. Its unique mechanism of action aims to enhance glycemic control and promote weight loss.

2 studiesDominant effect: metabolic
5-amino-1MQPreclinical

NNMT Inhibitor | Longevity & Metabolic Enhancement

Research-peptide often discussed for body recomposition: weight-loss–focused with muscle preservation, cholesterol and inflammation effects.

1 studyDominant effect: metabolic