Tesamorelin

Research-centric overview

Peptide

### Tesamorelin Summary Tesamorelin is a synthetic peptide that functions as a growth hormone-releasing hormone (GHRH) analog, primarily investigated for its potential to reduce visceral fat in individuals with HIV-associated lipodystrophy. Its role in metabolic health and body composition continues to be explored in various clinical contexts.

Community effect votes, structured logs, and side-effect summaries.

Effect profile (overview)

Aggregate AI baseline blended with community voting. Hover to inspect effect strengths per category.

Effect scores blend an AI baseline with community votes. Open the full chart to see sliders and vote on each category.

Research log summary heatmap

Compact view of how logs describe shifts in pain, sleep, and performance (−5 to +5). Treat this as qualitative, anonymous signal only.

No community research logs yet. When structured logs are added, this panel will summarize typical shifts in pain, sleep, and performance.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

No anonymous side-effect reports yet. When reports are submitted, this panel will show a simple heatmap of tags like "nausea", "flushing", "improved healing", and more.

Research footprint

Last analyzed Jun 2, 2026

Studies indexed

Human

Animal

AI analyzed

Evidence mix0% human · 0% animal · 0% cellular · 0% review

Highest phase: Preclinical onlyYears covered: 2026

Librarian pulse — latest actionsFull changelog ↓

Jun 2, 5:00 PMRe-scoredScored effects for Tesamorelin
Jun 1, 6:00 AMRefreshedRefreshed content for Tesamorelin
May 31, 6:00 AMRefreshedRefreshed content for Tesamorelin

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

Role of Growth Hormone in the Pathogenesis and Treatment of Cardiac Steatosis and Diastolic Dysfunction in HIVClinical TrialClinicalTrials.govPublished Jan 30, 2019Added May 27, 2026

This study examines the role of growth hormone in cardiac steatosis and diastolic dysfunction in HIV patients. The specific outcomes measured and the doses used are not reported in the abstract. The findings may provide insights into the relationship between growth hormone and cardiac function in this population.

Status: COMPLETED

A Prospective, Randomized, Placebo-controlled, Double-blind Clinical Trial to Evaluate Whether EGRIFTA® (Tesamorelin for Injection), 2 mg Once Daily SC, Increases the Risk of Development or Progression of Diabetic Retinopathy When Administered to HIV-infected Subjects With Abdominal Lipohypertrophy and Concomitant DiabetesClinical TrialClinicalTrials.govPublished Jun 1, 2012Added May 27, 2026

This study evaluated the risk of developing or progressing diabetic retinopathy in HIV-infected subjects with abdominal lipohypertrophy and concomitant diabetes receiving Tesamorelin (2 mg once daily SC). The study was placebo-controlled and double-blind. No therapeutic claims are made regarding the outcomes.

Phase: PHASE4Status: TERMINATED

A Randomized, Double-Blind, Placebo-Controlled Phase II Study of Tesamorelin (GHRH Analog) for Reducing Hepatic Steatosis in Adults With Metabolic Associated Steatotic Liver Disease (MASLD)Clinical TrialClinicalTrials.govPublished Feb 2, 2026Added Apr 16, 2026

This study evaluated the effects of Tesamorelin, a GHRH analog, on hepatic steatosis in adults diagnosed with Metabolic Associated Steatotic Liver Disease (MASLD). The study was randomized, double-blind, and placebo-controlled. Not reported in abstract.

Phase: PHASE2Status: RECRUITING

A Phase 4, Observational, Multicenter, 10-year Prospective Cohort Safety Study Comparing Subjects With HIV-associated Abdominal Lipohypertrophy Exposed to EGRIFTA® (Tesamorelin for Injection) to a Similar Group of Subjects Not Exposed to EGRIFTA®Clinical TrialClinicalTrials.govPublished Feb 1, 2013Added Apr 16, 2026

This study evaluated the safety of Tesamorelin in subjects with HIV-associated abdominal lipohypertrophy over a 10-year period. It compared outcomes between those exposed to Tesamorelin and a similar group not exposed. No therapeutic claims are made regarding the efficacy of the treatment.

Status: TERMINATED

Semantic Scholar search for TesamorelinStudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Metabolic dysfunction-associated steatotic liver disease in people with HIV.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Carpal Tunnel Syndrome Attributed to Medication Use: A Pharmacovigilance Study.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

External databases

Helpful external resources for additional structural, pharmacologic, and literature context. These are third-party databases; always cross-check details with primary research.

Community notes

No comments yet. Share research notes, citations, or observations below.

Community research logs (detail)

No community research logs yet. Use the “Contribute data” button above to share an anonymized summary of your experience.

Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

Use the "Report side effects" button to open a focused popup form. Please keep descriptions neutral and avoid medical language; think in terms of "nausea", "flushing", "vivid dreams", etc.

Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

58m agoScoring70%

Scored effects for Tesamorelin

1d agoRefreshai-researcher85%

Refreshed content for Tesamorelin

2d agoRefreshai-researcher85%

Refreshed content for Tesamorelin

3d agoRefreshai-researcher85%

Refreshed content for Tesamorelin

4d agoRefreshai-researcher85%

Refreshed content for Tesamorelin

6d agoRefreshai-researcher85%

Refreshed content for Tesamorelin

May 26Scoring70%

Scored effects for Tesamorelin

May 26Verificationai-researcher90%

Verified content for Tesamorelin: accurate

May 26task_runlibrarian-runner

Completed task: Find real articles for Tesamorelin (thin literature)

May 26Ingestiondiscovery

Searched for real articles on Tesamorelin

Apr 20Refreshdiscovery50%

Refreshed content for Tesamorelin

Apr 20SummarySemanticScholar0%

Auto-summarized study: "Semantic Scholar search for Tesamorelin..."

Apr 17Refreshai-researcher85%

Refreshed content for Tesamorelin

Apr 16Refreshai-researcher85%

Refreshed content for Tesamorelin

Apr 16Refreshai-researcher85%

Refreshed content for Tesamorelin