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L-Carnitine (Levocarnitine) record · updated 6h ago

Metabolic & appetiteMuscle & body compGrade A · human clinicalResearch use only
All 24 studiesJump to the evidenceCompare
What is L-Carnitine (Levocarnitine) used for?

L-Carnitine (levocarnitine) is an amino acid derivative that shuttles long-chain fatty acids into mitochondria for energy production, studied for metabolic, cardiovascular, and exercise performance applications.

How it works: Facilitates fatty acid entry into mitochondria for beta-oxidation

Primarily researched for · Metabolic & appetiteRoute · Oral, Intravenous

Development stage

where L-Carnitine (Levocarnitine) sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 141 registered trials. It describes the research record, not a recommendation.

Identity
NameL-Carnitine (Levocarnitine)
Chain length—
Molecular weight161.2 Da
FormulaC7H15NO3
Structure typeSmall molecule
ClassMetabolic
Research levelFDA Approved
Discovered byCurated master list · 2026

Mass and formula from PubChem CID 10917. No verified residue count for this compound.

Pharmacology
MechanismFacilitates fatty acid entry into mitochondria for beta-oxidation
RouteOral, Intravenous
Half-life~5.5 hours
Time to peak3–6 hours
Duration—
Extraction confidence0.90
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Sep 20, 2026. How this works →
Research stats
Total studies24
Human / animal / cellular10 / 7 / 0
Highest trial phasePhase 1
Years covered2023–2026
Latest study3d ago
Publication history
20232026
Research funding
377 NIH projects · $24.5M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reports70
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

24 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
The protective effect of chemical and natural compounds against amiodarone induced toxicity: A systematic review.
FindingNot reported in abstract.
review2026Full text read0.80
Advanced hydrogel-based drug delivery systems for psoriasis management: From material design to multi-target therapies.
TakeawayAdvanced hydrogel systems show promise for multi-target psoriasis therapies, but further research is needed to address clinical translation challenges.
review2026Full text read0.70
TIGAR coordinates polyol and glutamine metabolism to regulate CD4+ T cells
FindingNot reported in abstract.
Animal2026Full text read0.70
Traumatic brain injury alters hepatic gluconeogenic metabolism assessed using hyperpolarized pyruvate
FindingNot reported in abstract.
Animal2026Full text read0.70
Revealing potential biomarkers and metabolic mechanisms of ovarian aging in hens during late laying period based on machine learning and metabolomics.
FindingNot reported in abstract.
Animal2026Full text read0.70
Effects of rumen fluid transplantation on longissimus dorsi muscle development in Xizang sheep: An association analysis based on transcriptomic and serum metabolomic profiles.
FindingNot reported in abstract.
Animal2026Full text read0.70
Environmental risk factors for false-positive results in newborn screening for primary carnitine deficiency: a multicenter large-scale retrospective cohort study.
FindingFalse-positive rate was 94.0% (735/782).
Human2026Full text read0.80
Body mass index and dyslipidemia influence responses to anti-PD-1 immunotherapy in colorectal cancer.
FindingBMI ≥ 24 kg/m² associated with longer PFS, p=0.001.
Human2026Full text read0.80
Perinatal ampicillin exposure alters murine maternal fecal bile acid and acylcarnitine profiles.
FindingElevated fecal acylcarnitines observed.
Animal2026Full text read0.80
The bottleneck of fat burning.
TakeawayNot reported in abstract.
—2026Title only0.10
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation.
TakeawayNot reported in abstract.
—2026Title only0.10
Gestational diabetes mellitus induces sex-specific neonatal metabolomic signatures associated with early metabolic programming
FindingAUC of 0.810 (95% CI: 0.636–0.920) in males for distinguishing GDM-exposed from healthy infants.
Human2026Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching L-Carnitine (Levocarnitine) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much L-Carnitine (Levocarnitine) is discussed should be drawn from it.

Articles mentioning L-Carnitine (Levocarnitine)