Research library

C

grade

The study identified celosin I as the optimal pharmacokinetic marker for total saponins from Celosiae Semen, with significant effects observed in vitro and in a zebrafish model, but clinical relevance in humans remains unproven.

AUC₀-∞ was 215.45 μg·min/mL.

summary

C

grade

CPT1A may be a key regulator of energy metabolism and reproductive function in goat granulosa cells, but further research is needed to confirm its relevance in clinical settings.

Not reported in abstract.

summary

C

grade

This study constructed a six-gene risk model based on carnitine-related genes for predicting outcomes in head and neck squamous cell carcinoma, with some associations to immune cell infiltration.

The risk model achieved 1-, 3-, and 5-year AUC values of 0.65, 0.66, and 0.65 in the training set.

summary

D

grade

Current evidence does not support the routine use of any protective adjuncts with amiodarone, including L-Carnitine, due to a lack of clinical trials.

Not reported in abstract.

summary

D

grade

Advanced hydrogel systems show promise for multi-target psoriasis therapies, but further research is needed to address clinical translation challenges.

summary

C

grade

TIGAR is identified as a key regulator of CD4⁺ T-cell differentiation, linking metabolic pathways to immune responses, but findings are based on rodent models and require further validation in humans.

Not reported in abstract.

summary

C

grade

This study indicates that traumatic brain injury may enhance hepatic gluconeogenic metabolism, as assessed by hyperpolarized pyruvate in a rat model.

Not reported in abstract.

summary

C

grade

This study identifies long-chain acylcarnitines as potential biomarkers for ovarian aging in hens, which could help in understanding reproductive performance in poultry.

Not reported in abstract.

summary

C

grade

Rumen fluid transplantation may enhance muscle lightness and fiber characteristics in Xizang sheep, but the underlying mechanisms require further study.

Not reported in abstract.

summary

B

grade

Environmental conditions, especially temperature, can significantly impact newborn screening results for primary carnitine deficiency, leading to high false-positive rates.

False-positive rate was 94.0% (735/782).

summary

B

grade

Higher body mass index (BMI) appears to correlate with better outcomes in colorectal cancer patients receiving anti-PD-1 therapy, but further research is needed to confirm these findings.

BMI ≥ 24 kg/m² associated with longer PFS, p=0.001.

summary

C

grade

Maternal ampicillin exposure in mice alters the microbiome and metabolome, potentially impacting offspring weight gain. Human implications remain to be validated.

Elevated fecal acylcarnitines observed.

summary

D

grade

Not reported in abstract.

summary

D

grade

Not reported in abstract.

summary

B

grade

Intrauterine exposure to gestational diabetes mellitus results in distinct metabolic signatures in newborns, which differ by sex. These findings may help identify infants at risk due to maternal hyperglycemia.

AUC of 0.810 (95% CI: 0.636–0.920) in males for distinguishing GDM-exposed from healthy infants.

summary

B

grade

Fasting lactate responses after HIIT in T2DM patients show significant variability, indicating that individual metabolic adaptations can differ widely and may not align with conventional glycaemic improvements.

Fasting lactate in T2DM patients was 1.72 ± 0.70 mmol/L vs 1.06 ± 0.57 mmol/L in non-T2DM controls, P < 0.001.

summary

B

grade

This study introduces a new non-invasive method to measure muscle carnitine levels, showing lower concentrations in patients with mitochondrial disease, which correlates with dysfunction and lipid accumulation.

1.9-fold difference in total carnitine concentration within one muscle group due to orientation correction.

summary

D

grade

Not reported in abstract.

summary

A

grade

This study suggests that different dietary patterns can influence gut microbiome function and metabolic markers, but further research is needed to confirm these findings in larger populations.

91.7% held-out accuracy for dietary response discrimination, permutation p=0.005.

summary

C

grade

Guilu Erxian Oral Liquid may improve sperm quality and reduce oxidative stress in a mouse model of oligoasthenospermia, but further research is needed to confirm these effects in humans.

Not reported in abstract.

summary

B

grade

Early antibiotic exposure in preterm infants may impair their immune response to vaccines, especially in girls, highlighting the need for careful consideration of antibiotic use in this population.

Not reported in abstract.

summary

C

grade

Training at 75% oxygen concentration significantly enhances endurance capacity in well-trained mice, but the implications for human training remain unclear.

0.76-fold lower glutathione peroxidase-1 protein levels in PL muscle in INT75 vs ET.

summary

B

grade

This case suggests that intermittent hemodialysis with a medium cut-off dialyzer can effectively reduce valproic acid levels in severe poisoning cases, but further studies are needed to confirm these findings.

VPA decreased to 97.81 µg/mL at 4 h (62.8% reduction).

summary

B

grade

Riboflavin treatment at 100 mg/day for 6 months in a pediatric patient with L-2-hydroxyglutaric aciduria showed no clinical or biochemical effects.

Not reported in abstract.

summary

A

grade

The SUNRISE study showed that while gene editing can increase MMUT expression, it did not effectively normalize serum methylmalonic acid levels, and safety concerns were raised due to treatment-emergent adverse events.

Not reported in abstract.

summary