Advanced hydrogel-based drug delivery systems for psoriasis management: From material design to multi-target therapies.
Advanced hydrogel systems show promise for multi-target psoriasis therapies, but further research is needed to address clinical translation challenges.
Where it sits
this study against the rest of the l-carnitine (levocarnitine) corpusSummary and findings
This review discusses recent advances in hydrogel-based drug delivery systems for psoriasis management, focusing on multi-target therapies. It highlights the potential of smart hydrogels and nanogels for enhanced drug penetration and sustained release. The review also addresses future challenges in clinical translation, such as manufacturing standards and safety.
Abstract
Psoriasis is a chronic inflammatory skin disorder driven by the interplay of genetic, immunological, and environmental factors. Hydrogels, featuring excellent biocompatibility and tunable structures, have emerged as pivotal platforms for topical psoriasis management. Although existing studies have explored hydrogel drug delivery and sustained release, they often remain confined to single-target interventions or basic formulations. This review updates recent advances by elucidating intervention mechanisms from the pathological microenvironment. We highlight synergistic strategies using smart hydrogels and nanogels, with emphasis on their core strengths in sustained/controlled release, enhanced penetration, and dosage form design. Finally, future perspectives and targeted strategies are proposed to address critical bottlenecks in clinical translation, including manufacturing standards and long-term safety. This work aims to provide theoretical guidance for developing next-generation hydrogel formulations with high efficacy and low toxicity.
Background
Psoriasis is a chronic inflammatory skin condition influenced by genetic, immunological, and environmental factors. Traditional treatments often target single pathways, which may limit their effectiveness. This review is significant as it explores advanced hydrogel-based systems that can potentially offer multi-target therapeutic approaches, enhancing treatment efficacy.
Methods
This is a review article that synthesizes recent literature on hydrogel-based drug delivery systems for psoriasis. It does not involve primary research or experimental data collection. The review focuses on the design and application of smart hydrogels and nanogels in topical therapies.
Results
Not reported in abstract.
Interpretation
The review suggests that advanced hydrogel systems could provide more effective psoriasis treatments by targeting multiple pathways simultaneously. However, the lack of new experimental data limits the ability to assess the clinical significance of these findings. The emphasis on future challenges highlights the need for further research to address manufacturing and safety concerns.
Key findings
- Hydrogels offer excellent biocompatibility and tunable structures.
- Smart hydrogels and nanogels enhance penetration and controlled release.
- Current studies often focus on single-target interventions.
- Future strategies aim to improve clinical translation and safety.
Limitations
- No new experimental data provided
- Focuses on existing literature
- Lacks specific quantitative findings
- Challenges in clinical translation not resolved