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Kisspeptin (KP-10) record · updated 8h ago

Neuro & moodGrade A · human clinicalResearch use only
All 10 studiesJump to the evidenceCompare
What is Kisspeptin (KP-10) used for?

Kisspeptin (KP-10) is a 10-amino acid KISS1 gene fragment that activates KISS1R to drive GnRH release, studied as an upstream regulator of reproductive hormones and fertility.

Primarily researched for · Neuro & mood

Development stage

where Kisspeptin (KP-10) sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 15 registered trials. It describes the research record, not a recommendation.

Identity
NameKisspeptin (KP-10)
Full name—
Sequence—
ClassSexual Health
Research levelEmerging
Discovered byCurated master list · 2026
Pharmacology
Mechanism—
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence—
Effect profile · 0–5
Neuro & mood: Healing 0.0, Muscle 0.0, Metabolic 0.0, Neuro 3.0, Sleep 0.0, Immune 0.0, Skin 0.0Neuro & mood — 3.0 / 5HealingMuscleMetabolicNeuroSleepImmuneSkin0.00.00.03.00.00.00.0
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o mini over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Aug 6, 2026. How this works →
Research stats
Total studies10
Human / animal / cellular8 / 2 / 0
Highest trial phasePhase 4
Years covered2023–2027
Latest study3d ago
Publication history
20232027
Research funding
147 NIH projects · $24.9M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

10 rowsOpen in the library →
StudyTypeYearSummary depth
NVX-CoV2372, monovalent mRNA and bivalent mRNA vaccines elicit broadly cross-reactive antibodies against emerging SARS-CoV-2 variants.
Finding50% neutralization titers against strain XBB.1.16 boosted by 3.2-fold in monovalent mRNA, 4.1-fold in bivalent mRNA, and 1.6-fold in NVX-CoV2373 at day 28.
Human2026Full text read0.80
Safety of COVID-19 mRNA-1273 booster doses in Asian populations: A literature review of post-marketing observational studies.
FindingNot reported in abstract.
Human2026Full text read0.80
Post-competition recovery in natural physique athletes: body composition, metabolic adaptation, and refeeding responses.
Finding-7.1 kg body weight decrease from T0 to Tpre, n=19, 95% CI [-8.3, -5.9]
Human2026Full text read0.80
Immunogenicity and safety of an investigational quadrivalent measles, mumps, rubella, and varicella vaccine in children aged 4-6 years: A phase II, randomized, multi-country trial.
FindingNot reported in abstract.
Human2026Full text read0.80
Artificial intelligence readiness in Pakistan's medical and dental education: training-phase decline, a knowledge-practice paradox, and the role of digital determinants of health.
FindingMean knowledge score was 4.23 (SD 1.71) out of 7.
Human2026Full text read0.80
Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.
FindingKp-10/basal LH ratio cut-off <4.07 ng/mIU, sensitivity 72.7%, specificity 87.0%, accuracy 78%.
Human2026Full text read0.80
Effects of Zearalenone on the Kiss1/GPR54 System and Related Genes Expression in the Hypothalamus and Pituitary Gland of Weaned Gilts.
FindingNot reported in abstract.
Animal2023Full text read0.80
The Effect of 2.45 GHz Radiofrequency Electromagnetic Radiation on Components of the Hypothalamic-Pituitary-Gonadal Axis in Male Rats.
FindingGnRH levels increased significantly in both exposed groups, n=18.
Animal2026Full text read0.80
Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.
FindingKp-10/basal LH ratio cut-off <4.07 ng/mIU, sensitivity 72.7%, specificity 87.0%, accuracy 78%
Human2027Full text read0.80
Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.
FindingLimits of identification (LOI) ranged from 0.8 ng/mL (KP-54) to 10 pg/mL (TAK-448).
Human2026Full text read0.80

Articles mentioning Kisspeptin (KP-10)