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Kisspeptin (KP-10) record · updated 7h ago

Neuro & moodMetabolic & appetiteGrade A · human clinicalResearch use only
All 28 studiesJump to the evidenceCompare
What is Kisspeptin (KP-10) used for?

Kisspeptin (KP-10) is a decapeptide derived from the KISS1 gene, known for its role in the regulation of the hypothalamic-pituitary-gonadal (HPG) axis. It primarily functions by activating the KISS1 receptor (KISS1R), which stimulates the release of gonadotropin-releasing hormone (GnRH). This cascade is crucial for the regulation of reproductive hormones, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby influencing fertility and reproductive health.

How it works: KISS1 receptor agonist

Primarily researched for · Neuro & moodRoute · Subcutaneous injection

Development stage

where Kisspeptin (KP-10) sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 44 registered trials. It describes the research record, not a recommendation.

Identity
NameKisspeptin (KP-10)
Chain length—
Molecular weight5,857 Da
FormulaC258H401N79O78
Structure typeNot established
ClassHealing
Research levelWell Studied
Discovered byCurated master list · 2026

Mass and formula from PubChem CID 71306396. No verified residue count for this compound.

Pharmacology
MechanismKISS1 receptor agonist
RouteSubcutaneous injection
Half-life—
Time to peak—
Duration—
Extraction confidence0.80
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Oct 29, 2026. How this works →
Research stats
Total studies28
Human / animal / cellular13 / 10 / 2
Highest trial phasePhase 4
Years covered2023–2026
Latest study7d ago
Publication history
20232026
Research funding
149 NIH projects · $24.7M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

28 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Regulation of PACAP gene expression by ovarian sex steroids and kisspeptin: Study using hypothalamic cell lines and an <i>in vivo</i> female rat model.
Finding100 nM PACAP significantly increased Kiss-1 gene expression in all three hypothalamic cell lines.
Animal2026Full text read0.80
Kisspeptin-10 alleviates OGD/R-induced H9c2 cardiomyocyte injury by triggering autophagy via regulating the YY1/TFEB axis.
FindingNot reported in abstract.
In vitro2023Full text read0.70
Kiss1 neurons in the medial amygdala of mice are sexually dimorphic and unique from hypothalamic anteroventral periventricular Kiss1 neurons in their action potential firing properties
FindingNot reported in abstract.
Animal2026Full text read0.70
Differentiation of KISS1-Expressing Cells from Human Pluripotent Stem Cells: Many Roads To Rome
FindingNot reported in abstract.
In vitro2026Full text read0.70
Clinical immunogenicity and pharmacokinetic assessments of E3112, a recombinant human hepatocyte growth factor.
FindingHalf-life of 19.3 h.
Human2026Full text read0.70
T cell-associated immunity induced by heterologous recombinant BCG and purified protein vaccination confers cross-variant protection against SARS-CoV-2.
FindingNot reported in abstract.
Animal2026Full text read0.70
Day-to-day variability in resting metabolic rate in strength athletes.
FindingMean RMR was 26.9 ± 1.4 kcal·kgFFM⁻¹·day⁻¹ in males and 29.1 ± 1.7 kcal·kgFFM⁻¹·day⁻¹ in females.
Human2026Full text read0.80
Development and characterization of a topical ferrochelatase inhibitor nanoemulsion for choroidal neovascularization therapy.
FindingReduction in L-CNV by >45% compared to blank NEs.
Animal2026Full text read0.70
Hypothermic Conditions Impair GnRH Pulse Generator Activity and Gametogenesis
FindingNot reported in abstract.
Animal2026Full text read0.70
Human risk factors associated with the presence of antibodies against Mycobacterium tuberculosis complex in captive Asian elephants from Chitwan valley, Nepal.
Finding20.2% seroprevalence of MTC antibodies among elephants, 95% CI: 13-29%
Human2026Full text read0.80
Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans.
FindingKisspeptin administration increased serum luteinizing hormone, P < .001.
Human2025Full text read0.90
Sex Differences in Leptin Levels in Children and Adolescents with Normal Weight and Overweight/Obesity Across Pubertal Stages: A Systematic Review and Meta-analysis.
FindingPooled mean difference in leptin levels for girls with normal weight vs boys at all pubertal stages: 3.99, 95% CI, 2.63-5.35.
review2026Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Kisspeptin (KP-10) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Kisspeptin (KP-10) is discussed should be drawn from it.

Articles mentioning Kisspeptin (KP-10)