Peptides DB
Research-centric peptide and protocol reference hub

Humanin record · updated 17h ago

Neuro & moodHealing & recoveryGrade A · human clinicalResearch use only
All 21 studiesJump to the evidenceCompare
What is Humanin used for?

Humanin is a mitochondria-derived peptide that plays a significant role in cellular health and longevity. It is encoded by the mitochondrial genome and has been implicated in various cellular processes, including the regulation of apoptosis, inflammation, and oxidative stress. Humanin has been shown to exert protective effects in models of neurodegenerative diseases and metabolic disorders, suggesting its potential as a therapeutic agent in these conditions.

How it works: Binds to insulin receptor substrate, inhibits apoptosis, modulates mitochondrial function

Primarily researched for · Neuro & mood

Development stage

where Humanin sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 89 registered trials. It describes the research record, not a recommendation.

Identity
NameHumanin
Chain length—
Molecular weight2,687.2 Da
FormulaC119H204N34O32S2
Structure typeNot established
ClassLongevity
Research levelModerate Research
Discovered byAdded before provenance tracking · 2025

Mass and formula from PubChem CID 16131438. No verified residue count for this compound.

Pharmacology
MechanismBinds to insulin receptor substrate, inhibits apoptosis, modulates mitochondrial function
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence0.80
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Aug 26, 2026. How this works →
Research stats
Total studies21
Human / animal / cellular4 / 8 / 6
Highest trial phasePreclinical
Years covered2010–2026
Latest study6d ago
Publication history
20102026
Research funding
153 NIH projects · $32.7M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reports7
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

21 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Structural mechanism governing the directionality of bridge recombination.
FindingNot reported in abstract.
In vitro2026Full text read0.70
Effectiveness of WeChat-based interventions for glycemic control in patients with diabetes mellitus: A systematic review and meta-analysis.
FindingMD -1.10% HbA1c, 95% CI -1.78 to -0.42; I² = 85%; n=1742.
review2026Full text read0.80
Scaled Multidimensional Assays of Variant Effect Identify Sequence-Function Relationships in Hypertrophic Cardiomyopathy.
FindingNot reported in abstract.
In vitro2026Full text read0.70
Human pancreatic ductal cells from non-diabetic donors function as non-professional antigen-presenting cells upon inflammatory cytokine exposure.
FindingNot reported in abstract.
In vitro2026Full text read0.70
Development of a theory-based provider-focused training to improve HPV vaccine recommendations for young adults.
FindingNot reported in abstract.
Human2026Full text read0.70
Serum Index for Malignant Pleural Effusion (SIMPLE): A non-invasive, blood-based prognostic score for patients with newly diagnosed and relapsing MPE.
FindingSIMPLE AUC = 0.852 (95% CI 0.782-0.921).
Human2026Full text read0.80
Nigral biochemical and structural alterations following subacute exposure to MPTP in mice.
FindingSignificant (p < 0.05) increase in MDA level and decrease in SOD, CAT, and GSH.
Animal2026Full text read0.80
Impact of Mild Traumatic Brain Injury (mTBI) on CYP2D6 Activity and the Restorative Effects of Melatonin and Vitamin C Supplementation.
FindingCYP2D6 activity significantly suppressed on day 3 post-mTBI, p<0.05.
Animal2026Full text read0.70
Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.
FindingHN significantly decreased H2O2-induced granulosa cell apoptosis in KGN cells, p<0.01.
In vitro2023Full text read0.70
Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.
FindingP < 0.05 for TAS and GSH levels in seminal vesicle fluid.
Animal2026Full text read0.80
Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue.
FindingNot reported in abstract.
Animal2026Full text read0.70
Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.
FindingNot reported in abstract.
Animal2026Full text read0.70

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Humanin will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Humanin is discussed should be drawn from it.