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Semaglutide

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### Semaglutide Summary Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that has been investigated for its role in managing type 2 diabetes and obesity. Its efficacy in promoting weight loss and improving glycemic control has garnered significant attention in recent clinical research.

Community effect votes, structured logs, and side-effect summaries.

Effect profile (overview)

Aggregate AI baseline blended with community voting. Hover to inspect effect strengths per category.

Effect profile (AI + community): Metabolic & appetite 5.0/5 · Skin & aesthetics 4.0/5Healing 0.0Muscle 0.0Metabolic 5.0Neuro 0.0Sleep 0.0Inflammation 0.0Skin 4.0

Effect scores blend an AI baseline with community votes. Open the full chart to see sliders and vote on each category.

Research log summary heatmap

Compact view of how logs describe shifts in pain, sleep, and performance (−5 to +5). Treat this as qualitative, anonymous signal only.

Pain / discomfort0/5
Sleep / recovery+1/5
Performance / output+1/5

Based on 1 anonymized research log. Scroll down for full context and methodology.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

46%reduced appetite
35%early satiety
19%nausea

Research footprint

Last analyzed Jun 2, 2026
10
Studies indexed
1
Human
0
Animal
10
AI analyzed
Evidence mix10% human · 0% animal · 0% cellular · 0% review
Highest phase: Preclinical onlyYears covered: 2023–2026
Librarian pulse — latest actionsFull changelog ↓
  • Jun 2, 5:00 PMRe-scoredScored effects for Semaglutide
  • Jun 1, 6:00 AMRefreshedRefreshed content for Semaglutide
  • May 31, 6:00 AMRefreshedRefreshed content for Semaglutide

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

Retrospective Analysis of Outpatient Intervention Effects in Patients With Metabolic SyndromeClinical TrialClinicalTrials.govPublished Jun 1, 2023Added May 27, 2026

This study conducted a retrospective analysis to evaluate the effects of outpatient interventions in patients with metabolic syndrome. The specific interventions and doses are not detailed in the abstract. The outcomes measured and their significance are not reported in the abstract.

Status: UNKNOWN
Effect of Food on the Pharmacokinetics of Oral Semaglutide in Healthy SubjectsClinical TrialClinicalTrials.govPublished Jun 1, 2014Added May 27, 2026

This study evaluated the pharmacokinetics of oral semaglutide in healthy subjects under different food conditions. The findings indicate variations in absorption based on food intake. No therapeutic claims are made.

Phase: PHASE1Status: COMPLETED
RETRO-PROSPECTIVE OPEN STUDY TO ASSES GENETIC VARIABILITY AS A BASIS FOR PREDICTION OF THE RESPONSE TO GLP1 TREATMENTClinical TrialClinicalTrials.govPublished Oct 1, 2023Added May 27, 2026

This study assessed genetic variability as a predictor for response to GLP-1 treatment in patients. The specific dose of Semaglutide and the population characteristics were not detailed in the abstract. The findings regarding treatment response were not reported in the abstract.

Phase: NAStatus: UNKNOWN
A Pilot Human Study of the Safety, Tolerability and Effectiveness of the Aqua Medical Circumferential RF Vapor (RFV) Ablation System for Duodenal Mucosal Ablation for the Management of Insulin Requiring Type-2 Diabetes MellitusClinical TrialClinicalTrials.govPublished Oct 1, 2024Added May 27, 2026

This pilot study evaluated the safety, tolerability, and effectiveness of the Aqua Medical Circumferential RF Vapor Ablation System for duodenal mucosal ablation in patients with insulin-requiring Type 2 Diabetes Mellitus. The specific outcomes measured were not detailed in the abstract. The study's findings are relevant for understanding potential new interventions in diabetes management.

Phase: NAStatus: ACTIVE_NOT_RECRUITING
REVERsal to Normoglycemia by Treating PREDIABETES: The REVERT-PREDIABETES TrialClinical TrialClinicalTrials.govPublished Feb 1, 2026Added May 27, 2026

The REVERT-PREDIABETES trial evaluated the effects of semaglutide on individuals with prediabetes. The study aimed to assess the reversal of prediabetes to normoglycemia. Not reported in abstract.

Phase: PHASE3Status: NOT_YET_RECRUITING
Emulation of the STEP-HFpEF DM Heart Failure Trial in Healthcare Claims DataClinical TrialClinicalTrials.govPublished Jan 14, 2025Added Apr 16, 2026

This study emulates the STEP-HFpEF DM heart failure trial using healthcare claims data. It aims to analyze the outcomes associated with semaglutide in patients with heart failure with preserved ejection fraction and diabetes. No specific numeric results or treatment effects are reported in the abstract.

Status: COMPLETED
Impact of Antiobesity Medications on Appetite and Appetite-related Hormones and Metabolites.Clinical TrialClinicalTrials.govPublished Mar 1, 2025Added Apr 16, 2026

This study examines the impact of antiobesity medications on appetite and related hormones and metabolites. The specific medication studied is Semaglutide, although details on the population, dose, and outcomes are not provided in the abstract. The findings regarding appetite modulation and hormonal changes are not explicitly stated.

Status: NOT_YET_RECRUITING
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With PrediabetesClinical TrialClinicalTrials.govPublished Nov 22, 2021Added Apr 16, 2026

This study investigates the pharmacogenetic factors influencing the response to GLP-1 receptor agonists in Mexican-Americans with prediabetes. The specific outcomes measured were not detailed in the abstract. The study is categorized as a Phase 4 trial.

Phase: PHASE4Status: RECRUITING
Pilot Weight Loss Intervention With Dual GIP/GLP-1 Receptor Agonist Therapy in Patients With Endometrial Cancer and Obesity, Overweight, With or Without DiabetesClinical TrialClinicalTrials.govPublished Dec 19, 2024Added Apr 16, 2026

This study evaluated the effects of dual GIP/GLP-1 receptor agonist therapy on weight loss in patients with endometrial cancer and obesity, overweight, with or without diabetes. The specific dose and duration of treatment were not reported in the abstract. The outcomes measured included weight loss and other metabolic parameters.

Phase: EARLY_PHASE1Status: RECRUITING
A Phase 2, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled Study Evaluating the Safety and Efficacy of Semaglutide, and the Fixed-Dose Combination of Cilofexor and Firsocostat, Alone and in Combination, in Subjects With Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)Clinical TrialClinicalTrials.govPublished Aug 9, 2021Added Apr 16, 2026

This study evaluated the safety and efficacy of Semaglutide and the fixed-dose combination of Cilofexor and Firsocostat in subjects with compensated cirrhosis (F4) due to nonalcoholic steatohepatitis (NASH). The study was randomized, double-blind, and placebo-controlled. Specific numeric outcomes were not reported in the abstract.

Phase: PHASE2Status: COMPLETED
Semantic Scholar search for SemaglutideStudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Tirzepatide vs. Semaglutide: clinical decision-making in the GLP-1 landscape.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Sustained weight reduction with once-weekly semaglutide: results from a real-world retrospective cohort study in the United States (SCOPE 24 months).StudyPubMedPublished Jan 1, 2023Added Dec 12, 2025

Semaglutide may lead to a significant weight reduction of 12.4% over 24 months in a real-world setting, but individual results can vary.

GLP-1 receptor agonist utilization is associated with a low risk of Anesthesia-related complications prior to total joint arthroplasty.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Popular stacks

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External databases

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Community research logs (detail)

Showing the latest 1 logs out of 1.

Goal: weight / appetite

Context: sedentary / light 46-55

Duration ~16.0 weeks • ~1.0 doses/week

Δ scores
Pain +0Sleep +1Perf +1

Weekly GLP-1 agonist with gradual uptitration alongside nutrition coaching. Tracking appetite, weight trend, GI side-effects, and energy levels.

How to read these logs

Each entry is a single, anonymized “n=1” summary with relative change sliders from −5 to +5. Higher positive values indicate perceived improvement; negative values indicate perceived worsening.

Context (training level, age band, duration, and dosing frequency) is shown so you can quickly skim for patterns or outliers. Treat this as qualitative signal layered on top of study data, not as a substitute for controlled trials.

Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

Use the "Report side effects" button to open a focused popup form. Please keep descriptions neutral and avoid medical language; think in terms of "nausea", "flushing", "vivid dreams", etc.

Quick tone breakdown of submitted side-effect tags:

PositiveNegativeNeutral / mixed

Top reported tags so far (color reflects tone):

46%reduced appetite
35%early satiety
19%nausea

Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

58m agoScoring70%

Scored effects for Semaglutide

1d agoRefreshai-researcher85%

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2d agoRefreshai-researcher85%

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6d agoRefreshai-researcher85%

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May 26Scoring70%

Scored effects for Semaglutide

May 26Refreshai-researcher85%

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Apr 20Refreshdiscovery50%

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Apr 20SummarySemanticScholar0%

Auto-summarized study: "Semantic Scholar search for Semaglutide..."

Apr 17Refreshai-researcher85%

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Apr 16Refreshai-researcher85%

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