BPC-157 record · updated 18h ago

Healing & recoveryInflammation & immuneGrade B · human evidenceResearch use only

All 15 studies Jump to the evidence Compare

What is BPC-157 used for?

BPC-157, or Body Protective Compound-157, is a synthetic peptide derived from a protein found in human gastric juice. It has gained attention for its potential roles in soft-tissue repair, gastrointestinal (GI) support, and modulation of inflammation. The peptide is believed to exert its effects through various mechanisms, including the promotion of angiogenesis, modulation of growth factors, and reduction of oxidative stress and inflammation.

How it works: Body-protective compound (pentadecapeptide); cytoprotective, pro-angiogenic signaling

Primarily researched for · Healing & recoveryRoute · Subcutaneous / oral (research use)

Development stage

where BPC-157 sits between preclinical work and regulatory approval

1Current
Preclinical
Animal / in-vitro work
2Not reached
Phase 1
Safety in humans
3Not reached
Phase 2
Efficacy signal
4Not reached
Phase 3
Confirmatory trials
5Not reached
Approved
Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 83 registered trials. It describes the research record, not a recommendation.

Identity

NameBPC-157

Chain length15 amino acids

SequenceGEPPPGKPADDAGLV

Molecular weight1,419.5 Da

FormulaC62H98N16O22

Structure typePeptide

ClassHealing

Research levelPreclinical

Discovered byAdded before provenance tracking · 2025

Mass and formula from PubChem CID 9941957. The chain length is only shown where the residues account for that mass, so a figure here has been checked against it rather than taken on trust.

Pharmacology

MechanismBody-protective compound (pentadecapeptide); cytoprotective, pro-angiogenic signaling

RouteSubcutaneous / oral (research use)

Half-life—

Time to peak—

Duration—

Extraction confidence0.50

Effect profile · 0–5

These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Sep 30, 2026. How this works →

Research stats

Total studies15

Human / animal / cellular6 / 1 / 2

Highest trial phasePreclinical

Years covered2010–2026

Latest study17d ago

Publication history

20102026

Research funding

1,675 NIH projects · $27.3M awarded · through FY2026

Public grants naming this compound. Funding is interest, not evidence.

Safety signals

FAERS reports26

Serious AEs in animal work—

Community reports—

Positive —Neutral —Negative —

Records

ChEMBL ClinicalTrials.gov DrugBank Google Scholar PubChem PubMed · 15 Semantic Scholar UniProt

Study register

15 rows · newest 12 shownOpen in the library →

SortDate added ↓Publication year Evidence type Summary depth

Study	Type	Year	Summary depth
BPC 157 in Rodent Ischemia-Reperfusion Injury: A Critical Review of Preclinical Evidence. FindingNot reported in abstract.	review	2020	Full text read0.70
First Case Report of Triple Recurrent Cholangitis of "Coildocholithiasis," Following Hepatic Artery Pseudoaneurysm Embolization. FindingNot reported in abstract.	Human	2023	Full text read0.80
Mechanism of Fibrotic Anastomosis Formation in Endoscopic Ultrasound-guided Hepaticogastrostomy Using a Plastic Stent: Insights From an Autopsy Case of Perihilar Cholangiocarcinoma. FindingNot reported in abstract.	Human	2023	Full text read0.70
Endoscopic Diagnosis of <i>Necator americanus</i> Infection Presenting With Persistent Iron-Deficiency Anemia: Usefulness of Image-Enhanced Endoscopy and Capsule Endoscopy. FindingNot reported in abstract.	Human	2023	Full text read0.80
Time to Confirmed Completion of Bowel Preparation as a Preprocedural Indicator of Colonoscope Insertion Difficulty: A Prospective Observational Study. FindingEach 30-min increase in time to confirmed completion of bowel preparation was associated with longer cecal intubation time (exp(β), 1.139; 95% CI, 1.065-1.219).	Human	2023	Full text read0.80
Gastric Metastasis of Uterine Leiomyosarcoma Detected During Surveillance Endoscopy and Resected by Endoscopic Submucosal Dissection After Multiple Metachronous Metastases: A Case Report. FindingNot reported in abstract.	Human	2023	Full text read0.80
Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury. FindingNot reported in abstract.	Animal	2026	Full text read0.70
BPC-157 and Its Novel Hybrid Analogs as Inhibitors of Acetylcholinesterase. FindingIC50 value of CIARA-1 = 2.52 mM.	In vitro	2026	Full text read0.70
Evaluation of Research Grade Peptides Marketed Directly to Consumers Reveals Extensive Variability in Purity and Measured Abundance Finding41.6% to 71.1% of samples failed to meet basic quality criteria.	review	2020	Full text read0.80
BPC-157 and Its Novel Hybrid Analogs as Inhibitors of Acetylcholinesterase. FindingIC50 for CIARA-1 = 2.52 mM	In vitro	2023	Full text read0.80
Endothelium-Dependent Nitric Oxide-Mediated Vasorelaxant Effects of BPC 157 in Human Internal Mammary Artery. FindingNot reported in abstract.	Human	2026	Full text read0.80
Semantic Scholar search for BPC-157 TakeawayNot reported in abstract.	—	2010	Title only0.00

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching BPC-157 will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much BPC-157 is discussed should be drawn from it.