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BAM-15 record · updated 7h ago

Metabolic & appetiteNeuro & moodGrade B · human evidenceResearch use only
All 16 studiesJump to the evidenceCompare
What is BAM-15 used for?

BAM-15 is a mitochondrial protonophore uncoupler studied preclinically for obesity, insulin resistance, and metabolic dysfunction by increasing energy expenditure without raising heart rate.

How it works: Mitochondrial protonophore uncoupler

Primarily researched for · Metabolic & appetite

Development stage

where BAM-15 sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 36 registered trials. It describes the research record, not a recommendation.

Identity
NameBAM-15
Chain length—
Molecular weight—
Formula—
Structure type—
ClassMetabolic
Research levelPreclinical
Discovered byCurated master list · 2026
Pharmacology
MechanismMitochondrial protonophore uncoupler
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence0.70
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Oct 29, 2026. How this works →
Research stats
Total studies16
Human / animal / cellular10 / 2 / 0
Highest trial phasePreclinical
Years covered2015–2026
Latest study7d ago
Publication history
20152026
Research funding
96,201 NIH projects · $58.8M awarded · through FY2027
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

16 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.
TakeawayNot reported in abstract.
Animal2015Title only0.10
Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
TakeawayNot reported in abstract.
—2022Title only0.10
Structural basis for the binding of DNP and purine nucleotides onto UCP1.
TakeawayNot reported in abstract.
—2023Title only0.10
MicroRNA expression profile of fibro-adipogenic progenitors in Duchenne muscular dystrophy reveals dysregulation of adipogenesis-related microRNAs
FindingNot reported in abstract.
Human2026Full text read0.80
Guidance for clinical variant classification in genes for spliceosomal small nuclear RNAs
Finding∼50-fold increase in de novo mutation rate in snRNA genes compared to intergenic sequence.
review2026Full text read0.80
Towards a complete characterization of common human polymorphic inversions and their functional effects
Finding∼20% of inversions are in high linkage disequilibrium with GWAS signals.
Human2026Full text read0.70
Human GPR174 deficiency drives polyclonal lymphoproliferative disease via defects in T cell function
FindingNot reported in abstract.
Human2026Full text read0.80
Mutation timing, accumulation and selection in the male germline shape inheritance risk for developmental disorders
FindingGlobal dN/dS of 1.56 (95% CI 1.45–1.67) compared to 1.44 (95% CI 1.17–1.77) in controls.
Human2026Full text read0.80
A genome-wide deletion map in 125,730 individuals for novel rare disease gene and variant discovery
Finding213Mb or 6.92% of the human genome covered by these deletions.
Human2026Full text read0.80
The Role of Network Connectivity and Transcriptomic Vulnerability in Shaping Grey Matter Atrophy in Multiple Sclerosis
FindingNot reported in abstract.
Human2026Full text read0.80
Blood-based RNA-Seq of 5412 individuals with rare disease identifies new candidate diagnoses in the National Genomic Research Library
Finding20% of the cohort had at least one outlier event in a disorder-relevant gene.
Human2026Full text read0.80
A Spatio-Temporal Modelling of Climate Variability on Respiratory Disease Morbidity in Kampala City, Uganda
FindingStrong spatial clustering observed (edf ≈ 4, p < 0.001).
review2026Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching BAM-15 will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much BAM-15 is discussed should be drawn from it.