Peptides DB

Research-centric peptide and protocol reference hub

SS-31

Mitochondrial-Targeted Peptide | Cardiolipin Protector

Research-centric overview

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LongevityMetabolic
Well Studied

### Summary SS-31, also known as Elamipretide, is a peptide that has garnered attention for its potential role in mitochondrial protection and its implications in various health conditions, particularly those involving oxidative stress and mitochondrial dysfunction.

Community effect ratings, structured research logs, and side-effect patterns — all fed by one anonymous form.

Effect profile (overview)

Aggregate AI baseline blended with community voting. Hover to inspect effect strengths per category.

Effect profile (AI + community): Healing & recovery 3.0/5 · Muscle & body comp 2.0/5 · Metabolic & appetite 4.0/5 · Neuro & mood 4.0/5 · Inflammation & immune 3.0/5 · Skin & aesthetics 1.0/5Healing 3.0Muscle 2.0Metabolic 4.0Neuro 4.0Sleep 0.0Inflammation 3.0Skin 1.0

Effect scores blend an AI baseline with community ratings. Open the full chart for per-category detail; rate via the Contribute button.

Research log summary heatmap

Compact view of how logs describe shifts in pain, sleep, and performance (−5 to +5). Treat this as qualitative, anonymous signal only.

No community research logs yet. When structured logs are added, this panel will summarize typical shifts in pain, sleep, and performance.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

No anonymous side-effect reports yet. When reports are submitted, this panel will show a simple heatmap of tags like "nausea", "flushing", "improved healing", and more.

Research footprint

Last analyzed Jul 17, 2026
4
Studies indexed
0
Human
1
Animal
4
AI analyzed
Evidence mix0% human · 25% animal · 0% cellular · 0% review
Highest phase: PreclinicalYears covered: —
Librarian pulse — latest actionsFull changelog ↓
  • Jul 16, 3:59 PMRe-scoredSeeded effect profile for SS-31
  • Jul 16, 6:00 AMRefreshedRefreshed content for SS-31
  • Jul 15, 6:00 AMRefreshedRefreshed content for SS-31

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

A Pilot Investigator Initiated Study to Evaluate the Safety, Tolerability and Efficacy of Elamipretide in the Treatment of Advanced Symptoms of Friedreich Ataxia (FRDA)Clinical TrialClinicalTrials.govPublished Mar 3, 2022Added Apr 16, 2026

This study evaluated the safety, tolerability, and efficacy of Elamipretide (SS-31) in patients with advanced symptoms of Friedreich Ataxia (FRDA). The specific dose and duration of treatment were not reported in the abstract. The findings regarding efficacy and safety outcomes were not detailed.

Phase: PHASE1, PHASE2Status: COMPLETED
Evaluation of the Regeneration Capacity of Satellite Cells From the Quadriceps Compared to That of the DiaphragmClinical TrialClinicalTrials.govPublished Feb 18, 2022Added Apr 16, 2026

This study evaluated the regeneration capacity of satellite cells from the quadriceps compared to that of the diaphragm. The specific doses and methodologies used were not detailed in the abstract. The findings may provide insights into muscle regeneration mechanisms.

Phase: NAStatus: COMPLETED
Semantic Scholar search for SS-31StudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Targeted Delivery of AGO-2 to Myocardial Mitochondria via Functionalized Nanoparticles Attenuates Oxidative Stress in Diabetic Cardiomyopathy.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

NNT inhibits microglial activation via mitochondrial oxidative stress in spinal cord injury.StudyPubMedAdded Dec 12, 2025

The study explores SS-31's potential effects on microglial activation in spinal cord injury, but specific results and methodologies are not provided.

Targeted nanoliposomal nutrient delivery for human health.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

External databases

Helpful external resources for additional structural, pharmacologic, and literature context. These are third-party databases; always cross-check details with primary research.

Practical guides for SS-31

How-to and safety articles applicable to every peptide in the library.

Articles mentioning SS-31

Community notes

No comments yet. Share research notes, citations, or observations below.

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Community research logs (detail)

No community research logs yet. Use the “Contribute data” button above to share an anonymized summary of your experience.

Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

Use the "Report side effects" button to open a focused popup form. Please keep descriptions neutral and avoid medical language; think in terms of "nausea", "flushing", "vivid dreams", etc.

Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

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