Peptides DB
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Tesofensine record · updated 18h ago

Metabolic & appetiteNeuro & moodGrade A · human clinicalResearch use only
All 22 studiesJump to the evidenceCompare
What is Tesofensine used for?

Tesofensine is a synthetic compound that was initially developed as an antidepressant but has garnered interest for its potential role in weight loss and metabolic regulation. Its mechanism of action involves the inhibition of the reuptake of neurotransmitters such as serotonin, norepinephrine, and dopamine, which may lead to reduced appetite and increased energy expenditure. By modulating these neurotransmitters, tesofensine may help in regulating energy balance and body weight.

How it works: Serotonin, norepinephrine, and dopamine reuptake inhibitor

Primarily researched for · Metabolic & appetiteRoute · Oral

Development stage

where Tesofensine sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Current
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 14 registered trials. It describes the research record, not a recommendation.

Identity
NameTesofensine
Chain length—
Molecular weight328.3 Da
FormulaC17H23Cl2NO
Structure typeSmall molecule
ClassMetabolic
Research levelWell Studied
Discovered byAdded before provenance tracking · 2025

Mass and formula from PubChem CID 11370864. No verified residue count for this compound.

Pharmacology
MechanismSerotonin, norepinephrine, and dopamine reuptake inhibitor
RouteOral
Half-life~10 hours
Time to peak2–4 hours
Duration—
Extraction confidence0.80
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Sep 5, 2026. How this works →
Research stats
Total studies22
Human / animal / cellular9 / 3 / 6
Highest trial phasePhase 1
Years covered2010–2026
Latest study1mo ago
Publication history
20102026
Research funding
—no NIH grants found
Safety signals
FAERS reports11
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

22 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Ensemble Docking, MD, and MM/PBSA Identify Flavonoids as Putative Modulators of EFNB2/B3-Nipah Virus G Interaction.
FindingNot reported in abstract.
In vitro2026Full text read0.70
A tomato MIK2-clade receptor is involved in the perception of a Fusarium-derived elicitor.
FindingNot reported in abstract.
In vitro2026Full text read0.70
Long COVID symptom profiles, workforce participation, and working hours among adults in England: a population-based cohort study.
FindingAdjusted odds ratio [aOR]: 0.62, 95% CI: 0.55, 0.70 for being in paid work with unresolved Long COVID.
Human2026Full text read0.90
Occurrence of Phenotypic Multidrug-Resistant <i>E. coli</i> in Kentucky (USA) Surface Waters and Exploration of Sentinel Antibiotics for One Health Surveillance.
Finding100% TE non-susceptibility in E. coli from TE-treated media.
Animal2026Full text read0.80
MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights.
FindingSPRS scores increased with increasing age at examination after the age of 40 years.
review2026Full text read0.80
Design and computational evaluation of <i>E</i>-stilbene-bearing 1,3,4-oxadiazole derivatives as potential tyrosinase inhibitors using DFT, molecular docking and ADMET studies.
FindingIC50 values of 0.32 ± 0.03 µM and 0.76 ± 0.01 µM for compounds 5d and 5b, respectively.
In vitro2026Full text read0.70
Structural brain alterations in chronic primary pain: a multimodal MRI study.
FindingIncreased gyrification in left prefrontal regions in CPP patients.
Human2026Full text read0.80
HSP101-encoding NEO-TETRAPLOID RICE FERTILITY GENE 1 regulates tapetum development through interaction with SAPK2 in polyploid rice.
FindingSignificantly reduced seed-setting rate in ntrf1 mutants due to pollen developmental defects.
In vitro2026Full text read0.80
Design and evaluation of a novel peptide-EV complex for targeted Alzheimer's disease therapy.
FindingNear-complete suppression of Aβ fibrillation at 100 µM.
In vitro2026Full text read0.70
Plasma membrane transporters Alp1 and Nrt1 mediate the uptake of benzamidine conjugates in fungi.
TakeawayAlp1 and Nrt1 transporters are crucial for the uptake and antifungal activity of benzamidine conjugates in fungi, offering insights into overcoming resistance.
In vitro2026Full text read0.80
Chronic High-Fat Diet Does Not Alter Overall Cancer Incidence in Trp53R270H/+ Mice.
FindingNo significant effect on overall survival or tumor burden in Trp53R270H/+ mice after more than 1 year of HFD.
Animal2026Full text read0.90
Ultrasensitive Chemical Detection Using Integrating Cavity-Enhanced Raman Spectroscopy.
FindingPeak average reflectivity of 99.943 ± 0.0004% at 610 nm.
review2026Full text read0.70

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Tesofensine will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Tesofensine is discussed should be drawn from it.