Research library

B

grade

NAD(P) metabolism may reflect muscle health more accurately than age, with glutathione levels increasing independently of age-related changes.

Not reported in abstract.

summary

B

grade

Parasitic contamination in fruits and vegetables is prevalent in the Gedeo Zone, Ethiopia, highlighting the need for improved food safety practices and vendor hygiene.

33.5% contamination rate among 442 samples.

summary

B

grade

Caregivers find desmopressin easy to manage but challenging to prepare and administer, indicating a need for more user-friendly pediatric formulations.

Not reported in abstract.

summary

B

grade

Higher [68Ga]Ga-PSMA-11 SUVmean and SUVmean ratio may predict PSA response in [18F]FDG-positive mCRPC patients, but further research is needed.

PSA30 response in 44% of patients.

summary

B

grade

ARSi did not significantly enhance tumor absorbed doses in mCRPC patients receiving [177Lu]Lu-PSMA therapies. Larger studies are needed to confirm these findings.

2.1 ± 4.0 Gy/GBq vs 1.5 ± 1.7 Gy/GBq for [177Lu]Lu-PSMA-617, p=0.24

summary

A

grade

Capecitabine at 1000 mg/m² with Lu-PSMA is safe in heavily pre-treated mCRPC patients, but further research is needed to confirm efficacy.

MTD established at 1000 mg/m².

summary

B

grade

[225Ac]Ac-PSMA-617 shows promise for mCRPC with better survival and manageable toxicity, but further trials are needed.

PSA decline of >50% and disease control rate of 60% in [225Ac]Ac-PSMA-617 patients.

summary

B

grade

Young women with high perceived stress show distinct inflammatory profiles and lower BDNF levels, indicating a potential link between chronic stress and inflammation.

4E-BP1 log2FC = 0.565 in high perceived stress group.

summary

B

grade

This study highlights that structural brain deviations in various mental health conditions may follow a shared organizational pattern, but individual variability remains significant.

Not reported in abstract.

summary

B

grade

Higher estimated glucose disposal rate is associated with lower odds of self-reported endometrial cancer, suggesting a potential link between insulin sensitivity and cancer risk.

Odds ratio for eGDR inversely associated with self-reported EC was 0.906 (95% CI: 0.826-0.991, P = 0.0328)

summary

A

grade

Belzutifan plus lenvatinib showed a significant improvement in progression-free survival compared to cabozantinib, but overall survival did not reach statistical significance.

Median progression-free survival 14.8 months (95% CI 11.2-16.6) for belzutifan-lenvatinib vs 10.7 months (95% CI 9.2-11.1) for cabozantinib; HR 0.70, one-sided p<0.0001.

summary

B

grade

ASCL1 levels are lower in children with COVID-19 compared to those with non-COVID-19 bronchial pneumonia, and it correlates negatively with inflammation markers like neutrophils and CRP.

ACE2 in non-COVID-19 and moderate COVID-19 groups was higher than that in severe groups (p=0.04; p=0.03, respectively).

summary

A

grade

Tesamorelin significantly reduces visceral fat and improves lipid levels in HIV patients, but the long-term clinical implications of these changes are not fully understood.

-24 +/- 41 cm(2) VAT reduction in tesamorelin vs 2 +/- 35 cm(2) in placebo at 26 wk, P < 0.001.

summary

B

grade

Retatrutide increased the force of contraction in isolated human atrial preparations, but its clinical relevance and implications for patient care remain unclear.

Cumulatively applied retatrutide starting at 10 nM elevated FOC in HAP in a concentration- and time-dependent manner.

summary

A

grade

Pasireotide shows rapid absorption and sustained release in male volunteers with chronic kidney disease and hepatitis B/C, but the clinical implications of these findings are not yet clear.

Maximal concentration at 0.5 h after SC injection(s) of pasireotide (300-900 µg).

summary

B

grade

Octreotide treatment did not result in tumor shrinkage in any of the 21 patients with metastatic GEP tumors, and its clinical impact appears limited.

None of the 21 patients had documented shrinkage of the tumor mass.

summary

A

grade

SMS 201-995 significantly inhibits increases in serum gastrin during omeprazole therapy, which may be relevant for patients with severe hypergastrinaemia.

Not reported in abstract.

summary

B

grade

Octreotide treatment resulted in lower GH mRNA levels in adenomas compared to non-treated patients, but the clinical significance of these findings is unclear due to the small sample size.

GH mRNA in octreotide-treated adenomas was 4.2 +/- 1.8 (mean +/- SEM) in arbitrary units.

summary

B

grade

This study identified 383 genetic loci and 568 genes associated with heart failure, suggesting new therapeutic targets, particularly in metabolic pathways.

Identified 383 loci associated with heart failure, n=4,468,166.

summary

B

grade

Low-frequency genetic variants may drive the evolution of non-tuberculous mycobacterial populations, contributing to treatment failures during antibiotic therapy.

444 unique SNPs identified in 12 longitudinal isolates.

summary

B

grade

This study provides a framework for individualized dosing and switching strategies in pediatric GHD, emphasizing the importance of IGF-1 SDS in guiding treatment decisions.

Not reported in abstract.

summary

B

grade

LL-37 is expressed in ocular surface epithelia and shows significant antibacterial and antiviral activity in vitro, but further research is needed to confirm its clinical relevance.

EC50 values for three strains of Pseudomonas aeruginosa were 2.8 +/- 1.3, 1.9 +/- 0.3, and 3.6 +/- 2.1 microg/ml.

summary

B

grade

Leuprorelin treatment for ≥3 years does not show a significant benefit over 2 years in overall disease-free survival for premenopausal breast cancer patients, but may offer advantages for higher-risk individuals.

HR 0.944, 95% CI 0.486-1.8392 for DFS between ≥3 years and 2 years.

summary

B

grade

Higher body mass index (BMI) appears to correlate with better outcomes in colorectal cancer patients receiving anti-PD-1 therapy, but further research is needed to confirm these findings.

BMI ≥ 24 kg/m² associated with longer PFS, p=0.001.

summary

B

grade

This case highlights the potential for somatic mosaic AXIN2 mutations to cause colonic polyposis, suggesting a need for careful genetic evaluation in similar cases.

Not reported in abstract.

summary