Peptides DB
Research-centric peptide and protocol reference hub

Carbetocin record · updated 7h ago

Healing & recoveryNeuro & moodGrade A · human clinicalResearch use only
All 29 studiesJump to the evidenceCompare
What is Carbetocin used for?

Carbetocin is a synthetic analog of oxytocin, primarily used for the prevention of postpartum hemorrhage (PPH). It acts as a selective agonist at the oxytocin receptor, promoting uterine contractions and facilitating the expulsion of the placenta, which can significantly reduce the risk of excessive bleeding following childbirth. Unlike oxytocin, carbetocin has a longer half-life, allowing for sustained action with a single administration, which may enhance its efficacy in clinical settings.

How it works: Oxytocin receptor agonist

Primarily researched for · Healing & recoveryRoute · Subcutaneous injection

Development stage

where Carbetocin sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 68 registered trials. It describes the research record, not a recommendation.

Identity
NameCarbetocin
Chain length—
Molecular weight988.2 Da
FormulaC45H69N11O12S
Structure typeNot established
ClassHealing
Research levelFDA Approved
Discovered byThe Librarian · 2026

Mass and formula from PubChem CID 16681432. No verified residue count for this compound.

Pharmacology
MechanismOxytocin receptor agonist
RouteSubcutaneous injection
Half-life~2 hours
Time to peak—
Duration—
Extraction confidence0.90
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Oct 29, 2026. How this works →
Research stats
Total studies29
Human / animal / cellular17 / 3 / 0
Highest trial phasePhase 4
Years covered2023–2026
Latest study7d ago
Publication history
20232026
Research funding
—no NIH grants found
Safety signals
FAERS reports407
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

29 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Prophylactic Carbetocin Versus Oxytocin and Blood Loss After Vaginal Delivery: Agent Selection and Confounding by Indication in a Retrospective Cohort Study.
FindingBlood loss was higher with carbetocin before adjustment (223.7 vs. 180.0 mL, p = 0.003).
Human2023Full text read0.80
Oxytocin versus Carbetocin: Preventing Postpartum Hemorrhage in Elective C-section.
FindingCarbetocin group had 10% need for additional uterotonics vs 40% in oxytocin group, P = 0.007.
Human2023Full text read0.80
Uncorking Quantitative and Qualitative Seminal Traits in French-Alpine Bucks via Carbetocin Stimulation to Enhance Goat Production in Semi-Arid Environments.
FindingEjaculated volume increased by 103% with carbetocin compared to control, p ≤ 0.05.
Animal2023Full text read0.80
Neuraxial Medication Administration Errors During Anaesthesia and Perioperative Management, Consequences, Contributing Human and Systemic Factors and Their Prevention: A Systematic Review.
Finding54 patients included in the review.
review2026Full text read0.80
Carbetocin versus oxytocin during elective cesarean delivery: A randomized double-blind trial.
FindingIntraoperative blood loss was significantly lower in the carbetocin group than in the oxytocin group (p<0.001).
Human2023Full text read0.80
Graded Epidural Anaesthesia for Caesarean Section in the Presence of an Untreated Spetzler-Martin Grade V Cerebral Arteriovenous Malformation With Radiological Progression Over Six Years: A Case Report.
FindingNot reported in abstract.
Human2023Full text read0.80
Retrospective cost-effectiveness analysis of carbetocin for the prevention of postpartum hemorrhage after vaginal birth: Evidence from a tertiary maternity center in France.
FindingSevere PPH (≥1000 mL) occurred in 1.3% with carbetocin vs. 3.0% with oxytocin, P=0.0244.
Human2024Full text read0.80
The Effect of Carbetocin on Cardiac Repolarization: A Randomized, Placebo- and Positive-Controlled QT/QTc Study in Healthy Adults.
FindingEstimated mean placebo-corrected oQTcI change from baseline was 4.5 msec (90% CI: 3.4, 5.6).
Human2023Full text read0.80
Timing of carbetocin administration in vaginal deliveries: a double-blind, randomized controlled trial.
FindingIncidence of PPH was significantly lower in the carbetocin-before group than in the carbetocin-after group (p=0.015).
Human2025Full text read0.90
Administering carbetocin before electroejaculation in bulls improves semen quality and increases the number of insemination doses.
FindingSlightly enhanced semen mass motility (P = 0.05).
Animal2026Full text read0.70
Replacing Routine Oxytocin Infusion With Single-Dose Carbetocin at Elective Caesarean Section: A Service Improvement Evaluation of Postpartum Haemorrhage Outcomes.
FindingSignificant postpartum haemorrhage rates of 2.55% in the oxytocin cohort and 2.69% in the carbetocin cohort.
Human2024Full text read0.80
Induction of labor versus cesarean section after 36 + 0 weeks in twin pregnancy: A review of maternal and neonatal outcomes.
Finding71.2% (n=272) achieved vaginal delivery of both babies in the IOL group.
review2023Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Carbetocin will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Carbetocin is discussed should be drawn from it.

Articles mentioning Carbetocin