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Carbetocin record · updated 6h ago

Healing & recoveryNeuro & moodGrade A · human clinicalResearch use only
All 21 studiesJump to the evidenceCompare
What is Carbetocin used for?

Carbetocin is a synthetic analog of oxytocin, primarily used for the prevention of postpartum hemorrhage (PPH). It acts as a selective agonist at the oxytocin receptor, promoting uterine contractions and facilitating the expulsion of the placenta, which can significantly reduce the risk of excessive bleeding following childbirth. Unlike oxytocin, carbetocin has a longer half-life, allowing for sustained action with a single administration, which may enhance its efficacy in clinical settings.

How it works: Oxytocin receptor agonist

Primarily researched for · Healing & recoveryRoute · Subcutaneous injection

Development stage

where Carbetocin sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 63 registered trials. It describes the research record, not a recommendation.

Identity
NameCarbetocin
Chain length—
Molecular weight988.2 Da
FormulaC45H69N11O12S
Structure typeNot established
ClassHealing
Research levelFDA Approved
Discovered byThe Librarian · 2026

Mass and formula from PubChem CID 16681432. No verified residue count for this compound.

Pharmacology
MechanismOxytocin receptor agonist
RouteSubcutaneous injection
Half-life~2 hours
Time to peak—
Duration—
Extraction confidence0.90
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Sep 19, 2026. How this works →
Research stats
Total studies21
Human / animal / cellular11 / 2 / 0
Highest trial phasePhase 4
Years covered2023–2026
Latest study10d ago
Publication history
20232026
Research funding
—no NIH grants found
Safety signals
FAERS reports406
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

21 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Timing of carbetocin administration in vaginal deliveries: a double-blind, randomized controlled trial.
FindingIncidence of PPH was significantly lower in the carbetocin-before group than in the carbetocin-after group (p=0.015).
Human2025Full text read0.90
Administering carbetocin before electroejaculation in bulls improves semen quality and increases the number of insemination doses.
FindingSlightly enhanced semen mass motility (P = 0.05).
Animal2026Full text read0.70
Replacing Routine Oxytocin Infusion With Single-Dose Carbetocin at Elective Caesarean Section: A Service Improvement Evaluation of Postpartum Haemorrhage Outcomes.
FindingSignificant postpartum haemorrhage rates of 2.55% for oxytocin and 2.69% for carbetocin.
Human2024Full text read0.80
Induction of labor versus cesarean section after 36 + 0 weeks in twin pregnancy: A review of maternal and neonatal outcomes.
Finding71.2% (n=272) achieved vaginal delivery of both babies in the IOL group.
review2023Full text read0.80
Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) therapy of uterine fibroids effectively reduces both bleeding and bulk symptoms-A prospective single-center 12-month follow-up study.
FindingOverall mean NPV% for all patients was 62%.
Human2023Full text read0.80
Five-Year Trends in Obstetric Hemorrhage, Hemostatic Management, and Blood Product Utilization at a Tertiary Maternity Center in Kazakhstan: A Retrospective Time-Series Study.
FindingRecorded hemorrhage rate fell from 11.39 to 3.62 per 1000 deliveries, rate ratio 0.318, 95% CI 0.217-0.466.
review2023Full text read0.90
Carbetocin vs oxytocin for prevention of postpartum hemorrhage in women with obesity undergoing cesarean delivery: A systematic review and meta-analysis.
FindingMD -230.11 ml blood loss with carbetocin vs oxytocin; 95% CI -370.90 to -89.33; p = 0.0014
review2026Full text read0.80
Increasing matrix metalloproteinase-2 (MMP-2) activity by treatment of ovine cervical explants with a long-acting analogue of oxytocin (Carbetocin) at the expected time of artificial insemination.
FindingA MMP-2 activity was higher in 32 ng/mL Cb treated samples than in untreated samples (P < 0.03).
Animal2024Full text read0.70
Heat-stable carbetocin vs. oxytocin for the prevention of postpartum hemorrhage: a cost-effectiveness analysis based on real-world data from a pilot implementation in India
FindingHSC saved approximately US$473 per DALY averted.
review2026Full text read0.90
Efficacy of Carbetocin versus Conventional Uterotonic Regimens in Reducing Postpartum Blood Loss: A Comparative Study in Low-Risk Vaginal and Cesarean Deliveries
Finding100 mL primary blood loss with carbetocin vs. 150 mL with triple-drug regimen, P < 0.001.
Human2026Full text read0.80
Comparative Effectiveness of Uterotonic Agents for Postpartum Hemorrhage Prevention after Vaginal Delivery: A Retrospective Analysis of a Multicenter Prospective Cohort in Korea
FindingNot reported in abstract.
Human2026Full text read0.80
Carbetocin vs Oxytocin in Emergency Cesarean Delivery: Bleeding Outcomes Within 24 Hours
FindingAdditional uterotonic use occurred in 24.0% (36/150) of the carbetocin group and 33.3% (50/150) of the oxytocin group (p=0.074).
Human2026Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Carbetocin will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Carbetocin is discussed should be drawn from it.