Research library

A

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Administering carbetocin before placental delivery may reduce the incidence of postpartum hemorrhage, but it is associated with a higher rate of manual placenta removal.

Incidence of PPH was significantly lower in the carbetocin-before group than in the carbetocin-after group (p=0.015).

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C

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Carbetocin may slightly improve semen quality and yield in bulls, but the clinical significance of these findings remains uncertain.

Slightly enhanced semen mass motility (P = 0.05).

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B

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Replacing routine oxytocin infusion with single-dose carbetocin in elective caesarean sections showed comparable rates of significant and major postpartum haemorrhage.

Significant postpartum haemorrhage rates of 2.55% for oxytocin and 2.69% for carbetocin.

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B

grade

Induction of labor in uncomplicated twin pregnancies may be associated with higher neonatal admissions compared to elective cesarean section, but both methods are considered safe.

71.2% (n=272) achieved vaginal delivery of both babies in the IOL group.

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B

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MR-HIFU therapy significantly reduces symptoms and improves quality of life in women with uterine fibroids over a 12-month period.

Overall mean NPV% for all patients was 62%.

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B

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The study reports a significant decline in obstetric hemorrhage rates at a maternity center, but causative factors remain unclear due to data limitations.

Recorded hemorrhage rate fell from 11.39 to 3.62 per 1000 deliveries, rate ratio 0.318, 95% CI 0.217-0.466.

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A

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Carbetocin may reduce postpartum hemorrhage more effectively than oxytocin in obese women undergoing cesarean delivery, but larger studies are needed to confirm these findings.

MD -230.11 ml blood loss with carbetocin vs oxytocin; 95% CI -370.90 to -89.33; p = 0.0014

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C

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Carbetocin treatment increased MMP-2 activity in cervical explants from sheep, but the clinical significance of this finding is unclear.

A MMP-2 activity was higher in 32 ng/mL Cb treated samples than in untreated samples (P < 0.03).

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D

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HSC is suggested to be a more cost-effective option than oxytocin for preventing postpartum hemorrhage in India, potentially saving US$473 per DALY averted.

HSC saved approximately US$473 per DALY averted.

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B

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Carbetocin may reduce postpartum blood loss more effectively than traditional multi-drug regimens in vaginal deliveries, but further studies are needed to confirm these findings.

100 mL primary blood loss with carbetocin vs. 150 mL with triple-drug regimen, P < 0.001.

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B

grade

Carbetocin is frequently used for postpartum hemorrhage prevention and may reduce hemoglobin decrease compared to oxytocin, but the evidence lacks statistical significance.

Not reported in abstract.

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B

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In antenatally low-risk women undergoing emergency cesarean delivery, carbetocin and oxytocin appear to have similar effects on bleeding outcomes within 24 hours.

Additional uterotonic use occurred in 24.0% (36/150) of the carbetocin group and 33.3% (50/150) of the oxytocin group (p=0.074).

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B

grade

Carbetocin appears to preserve uterine contractility after prior exposure to oxytocin, which could be relevant for managing postpartum hemorrhage.

Sequential oxytocin administration significantly reduced contraction frequency (p < 0.05).

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D

grade

Not reported in abstract.

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D

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Not reported in abstract.

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B

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In this study, no significant differences were found in bleeding outcomes between carbetocin and oxytocin in women undergoing emergency cesarean delivery. Both medications showed similar rates of additional uterotonic use.

Additional uterotonic use occurred in 24.0% (36/150) of the carbetocin group and 33.3% (50/150) of the oxytocin group (p=0.074).

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B

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The study shows that while key interventions for managing postpartum hemorrhage are available in many countries, significant gaps remain in the integration of newer treatments like heat-stable carbetocin into national guidelines.

Oxytocin regularly available in public facilities by 77% of countries.

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A

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Carbetocin may reduce blood loss after vaginal delivery compared to oxytocin, but the clinical significance of this finding is uncertain.

-28.13 mL mean difference in blood loss vs oxytocin at 24 h, n=7403, p=0.020

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A

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Carbetocin nasal spray did not show significant efficacy compared to placebo in treating hyperphagia in Prader-Willi Syndrome over a 12-week period.

Treatment difference 0.3 (95% CI: -1.8, 2.4; P = 0.79)

summary

A

grade

TXA may reduce intraoperative blood loss during cesarean delivery, but the clinical relevance of the findings is uncertain due to small effect sizes and study limitations.

Mean EBL in TXA group was 460.33 mL vs 511.93 mL in placebo group, p < 0.05.

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B

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Carbetocin may lead to faster placental separation and reduced blood loss compared to oxytocin, but further research is needed to confirm these findings and assess their clinical significance.

Not reported in abstract.

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