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Glutathione (GSH) record · updated 8h ago

Inflammation & immuneHealing & recoveryGrade A · human clinicalResearch use only
All 6 studiesJump to the evidenceCompare
What is Glutathione (GSH) used for?

Glutathione (GSH) is an endogenous tripeptide and the body's master intracellular antioxidant, studied for oxidative stress, detoxification, immune function, and skin pigmentation research.

How it works: Antioxidant and redox cycling

Primarily researched for · Inflammation & immuneRoute · Intravenous injection, oral, inhalation

Development stage

where Glutathione (GSH) sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 27 registered trials. It describes the research record, not a recommendation.

Identity
NameGlutathione (GSH)
Full name—
Sequence—
ClassMetabolic
Research levelPreclinical
Discovered byCurated master list · 2026
Pharmacology
MechanismAntioxidant and redox cycling
RouteIntravenous injection, oral, inhalation
Half-life—
Time to peak—
Duration—
Extraction confidence0.80
Effect profile · 0–5
Inflammation & immune: Healing 4.0, Muscle 1.0, Metabolic 3.0, Neuro 4.0, Sleep 2.0, Immune 5.0, Skin 3.0Healing & recovery — 4.0 / 5Muscle & body comp — 1.0 / 5Metabolic & appetite — 3.0 / 5Neuro & mood — 4.0 / 5Sleep & circadian — 2.0 / 5Inflammation & immune — 5.0 / 5Skin & aesthetics — 3.0 / 5HealingMuscleMetabolicNeuroSleepImmuneSkin4.01.03.04.02.05.03.0
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o mini over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Jul 27, 2026. How this works →
Research stats
Total studies6
Human / animal / cellular1 / 4 / 1
Highest trial phasePreclinical
Years covered2026
Latest study10d ago
Publication history
20262026
Research funding
3,055 NIH projects · $25.7M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reports3
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

6 rowsOpen in the library →
StudyTypeYearSummary depth
Effect of Ebselen on Glucose and Redox Homoeostases in Diabetic Rats Exposed to Fenton Reagent and Crude Oil
FindingNot reported in abstract.
Animal2026Full text read0.70
Epstein-Barr virus transformation creates a methionine-dependent ferroptosis vulnerability in B cells
FindingNot reported in abstract.
In vitro2026Full text read0.70
The efficacy of N-acetylcysteine in the management of chronic obstructive pulmonary disease: a systematic review and meta-analysis.
FindingRR = 0.87, 95% CI [0.79-0.96], p=0.006 for acute exacerbations.
Human2026Full text read0.80
Neuroprotective potential of marine-derived polysaccharide against Aβ42-induced toxicity in a Drosophila Alzheimer's disease model.
FindingNot reported in abstract.
Animal2026Full text read0.70
Hesperidin mitigates cognitive and anxiety-like deficits by enhancing hippocampal antioxidant defenses, reducing neuroinflammation, and preventing neuronal apoptosis in a third-trimester-equivalent rat model of developmental ethanol neurotoxicity.
FindingEthanol decreased open arm time (Oat%) and entries (OAE%) (P < 0.001, P < 0.01 vs Control).
Animal2026Full text read0.70
Sulforaphane enhances locomotor recovery after spinal cord injury through antioxidant, anti-inflammatory, and JAK/STAT-modulating mechanisms.
FindingNot reported in abstract.
Animal2026Full text read0.70

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