Research library

A

grade

Nasal high flow may reduce opioid needs during ERCP without affecting oxygenation or sedation depth, but further multi-center studies are needed.

Median pethidine dose 43.75 mg NHF vs 70.00 mg LFO, p=0.004.

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C

grade

The new recombineering system enhances genetic manipulation of Edwardsiella species, aiding research into pathogenesis and vaccine development.

Extending homology arms from 150 bp to 200 bp improved editing efficiency by 2-fold.

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C

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Ribosome engineering in yeast can significantly enhance ncAA incorporation, but the impact on growth and translation may limit broader application.

2.9-fold increase in ncAA-dependent GFP production in ribo-hyper strain.

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C

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Dietary chestnut pollen may improve growth and immune responses in European catfish, but the practical implications require further investigation.

Not reported in abstract.

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C

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Loss of NKX2-1 in thyroid cells may increase the risk of cancer by promoting oxidative stress, particularly in the presence of radiation and iodine deficiency.

Not reported in abstract.

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C

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GSTT2 expression increases in treatment-resistant esophageal adenocarcinoma, indicating a potential shift in its role from antioxidant to cell cycle regulator.

Not reported in abstract.

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B

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NAD(P) metabolism may reflect muscle health more accurately than age, with glutathione levels increasing independently of age-related changes.

Not reported in abstract.

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C

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Dietary thymol supplementation improved growth performance and reproductive hormone levels in growing rams, but the clinical relevance of these findings needs further investigation.

Increased average daily gain, P<0.01.

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C

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Systemic LPS induces a coordinated sickness state in female BALB/c mice, affecting both metabolic and behavioral responses.

Not reported in abstract.

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B

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Simulation-based training can improve emergency response knowledge among endoscopy staff, but ongoing training may be necessary to maintain these improvements.

Correct chest compression improved, p < 0.01.

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D

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Intermittent fasting may help reduce HbA1c levels in adults with type 2 diabetes and should be considered as a lifestyle option in clinical practice.

HbA1c reduction typically by 0·3-1·2%.

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A

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Insulin glargine did not show a significant benefit over human isophane insulin in managing time in very low or target glucose ranges in children and young adults with type 1 diabetes in low-resource settings.

Adjusted mean difference for time in very low range was 0.22% (97.5% CI -0.83 to 1.27, p=0.63).

summary

C

grade

Supplementation with G. salicornia and T. conoides may improve certain immune and antioxidant markers in dogs, but the clinical significance of these changes remains uncertain.

Serum cortisol concentrations were significantly lower in the GS and TC groups than in the control (P<0.05).

summary

C

grade

Juvenile fourfinger threadfin exposed to low temperatures show significant oxidative stress and metabolic reprogramming, which may impact their survival and growth in aquaculture settings.

MDA levels significantly surged by day 14, indicating severe late-stage lipid peroxidation.

summary

C

grade

This study identifies a potential mechanism by which ESCC cells develop radioresistance, highlighting the GALNT2-METTL3-GPX4 axis as a target for future research.

Not reported in abstract.

summary

C

grade

DMT and 5-MeO-DMT show different effects on behavior and neuroplasticity in mice, which may inform future psychedelic treatments, but findings are not directly applicable to humans.

Not reported in abstract.

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C

grade

This study highlights significant metabolic changes in cone-dominant and degenerating retinas, particularly increases in glutathione and aminoadipate, which may indicate metabolic vulnerabilities in retinal health.

Not reported in abstract.

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C

grade

Desmidorchis adenensis extracts showed significant wound closure in a mouse model, but further research is needed to confirm these effects in humans.

5% DAd-MR accelerated wound closure to 97% (P < 0.05).

summary

C

grade

Synedrella nodiflora showed statistically significant effects in reducing markers of oxidative stress in HepG2 cells, but clinical implications in humans remain unclear.

p<0.01 reduction in caspase 3 activity in CCl4-induced HepG2 cells upon treatment with S. nodiflora.

summary

A

grade

Combining lidocaine spray with viscous lidocaine solution significantly reduced procedural discomfort and improved conditions during non-sedated EGD compared to lidocaine spray alone.

mean VAS 1.6 ± 1.1 vs. 3.1 ± 1.7; p = 0.01

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D

grade

Online PrEP and PEP could significantly reduce HIV infections in western Kenya, with a cost-effectiveness ratio of $212 per DALY averted.

$212 per DALY averted.

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C

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IDR-1002 shows promise in activating the Nrf2 antioxidant response and reducing inflammation in endothelial cells, but its clinical relevance in humans is not established.

EC50 of 18.57 μM for Nrf2-mediated transcriptional activity.

summary

C

grade

Ophthalmate appears to enhance GABA and dopamine release in the striatum, suggesting it may play a role in motor control regulation.

Not reported in abstract.

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B

grade

SEE-AI significantly improved lesion detection rates and reduced reading time in small bowel capsule endoscopy compared to conventional methods.

Per-lesion sensitivity: 98.8% (1532/1550) for AI vs 86.4% (1339/1550) for conventional reading, p<0.0001.

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B

grade

OSSs achieved high-quality bowel cleansing with a lower fluid intake, and taste acceptability was a key factor in patient preference, especially among elderly males.

98% achieved satisfactory cleansing (BBPS ≥ 6) among 263 patients.

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