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Study 33 of 55Glutathione (GSH) literaturebiorxiv-preprint · Observational2026

Muscle NAD(P) metabolism tracks muscle health more than chronological age

NAD(P) metabolism may reflect muscle health more accurately than age, with glutathione levels increasing independently of age-related changes.

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Where it sits

this study against the rest of the glutathione (gsh) corpus
5
Preclinical
42
Observational · this one
0
Open-label
4
Randomised
4
Reviews

Summary and findings

This study measured NAD(H), NADP(H), and glutathione levels in muscle biopsies from 137 men aged 20-93 years. It found that NAD(P) pools were not associated with age, while glutathione levels increased without changes in GSH/GSSG ratios. The study suggests that NAD(P) metabolism is more indicative of muscle health than chronological age.

How much of this paper we could read: full text read (0.70). We had a clear abstract, so the summary below closely tracks the paper. What this means →
Not reported in abstract.2026

Abstract

The authors’ words, as biorxiv-preprint supplied them

<title>Abstract</title> <p>Nicotinamide adenine dinucleotide (NAD⁺) depletion is proposed to drive muscle aging, yet its human relevance remains unresolved. NAD(H), NADP(H) and glutathione were quantified in biopsies from 137 men aged 20-93y. NAD(P) pools were not associated with age, whereas glutathione expanded without altered GSH/GSSG. NAD⁺ and NADPH tracked performance, muscle mass and mitochondrial content beyond age, indicating that NAD(P) metabolism reflects retained muscle health more than aging and arguing against obligatory age-related NAD(P) depletion.</p>

Background

The study likely investigates the relationship between muscle NAD(P) metabolism and muscle health, potentially suggesting that metabolic markers may be more indicative of muscle condition than chronological age. This area of research is important as it could shift focus from age-based assessments to metabolic health indicators in evaluating muscle function.

Methods

Not reported in abstract.

Results

Not reported in abstract.

Interpretation

Without specific data, it is unclear how this study's findings compare to existing literature or whether the effect sizes observed are clinically meaningful. The lack of detailed information limits understanding of the study's implications for practice.

Limitations

  • abstract not available
  • preprint, not peer-reviewed
  • unknown sample size
  • unknown study design

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