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Sermorelin

Research-centric overview

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### Summary Sermorelin is a synthetic peptide that mimics growth hormone-releasing hormone (GHRH), stimulating the pituitary gland to produce and release endogenous growth hormone. It has been investigated for its potential therapeutic applications, particularly in the context of growth hormone deficiencies and other related conditions.

Community effect votes, structured logs, and side-effect summaries.

Effect profile (overview)

Aggregate AI baseline blended with community voting. Hover to inspect effect strengths per category.

Effect profile (AI + community): Healing & recovery 3.0/5 · Muscle & body comp 4.0/5 · Metabolic & appetite 3.0/5 · Neuro & mood 2.0/5 · Sleep & circadian 2.0/5 · Inflammation & immune 1.0/5 · Skin & aesthetics 3.0/5Healing 3.0Muscle 4.0Metabolic 3.0Neuro 2.0Sleep 2.0Inflammation 1.0Skin 3.0

Effect scores blend an AI baseline with community votes. Open the full chart to see sliders and vote on each category.

Research log summary heatmap

Compact view of how logs describe shifts in pain, sleep, and performance (−5 to +5). Treat this as qualitative, anonymous signal only.

No community research logs yet. When structured logs are added, this panel will summarize typical shifts in pain, sleep, and performance.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

No anonymous side-effect reports yet. When reports are submitted, this panel will show a simple heatmap of tags like "nausea", "flushing", "improved healing", and more.

Research footprint

Last analyzed Jun 2, 2026
4
Studies indexed
0
Human
1
Animal
4
AI analyzed
Evidence mix0% human · 25% animal · 0% cellular · 0% review
Highest phase: PreclinicalYears covered: 2026
Librarian pulse — latest actionsFull changelog ↓
  • Jun 2, 5:00 PMRe-scoredScored effects for Sermorelin
  • Jun 1, 6:00 AMRefreshedRefreshed content for Sermorelin
  • May 31, 6:00 AMRefreshedRefreshed content for Sermorelin

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

Body Composition and Adipose Tissue in HIV Lipodystrophy: Effects of Tesamorelin TherapyClinical TrialClinicalTrials.govPublished Feb 7, 2018Added May 27, 2026

This study evaluated the effects of Tesamorelin therapy on body composition and adipose tissue in individuals with HIV lipodystrophy. The specific dosage and duration of therapy were not reported in the abstract. The findings indicate changes in body composition metrics, but no therapeutic claims are made.

Phase: PHASE4Status: TERMINATED
GHRH: Cognition in Aging and MCIClinical TrialClinicalTrials.govPublished Feb 1, 2006Added May 27, 2026

This study investigated the effects of GHRH (Sermorelin) on cognition in aging individuals and those with mild cognitive impairment (MCI). The specific dose and duration of treatment were not reported in the abstract. The outcomes measured were cognitive function and related assessments.

Phase: PHASE2Status: COMPLETED
Assessment of Cardiovascular Risk Markers in GH Deficient Patients With Nonsecreting Pituitary AdenomasClinical TrialClinicalTrials.govPublished Feb 1, 2007Added May 27, 2026

This study assessed cardiovascular risk markers in growth hormone (GH) deficient patients with nonsecreting pituitary adenomas. The specific dose of Sermorelin administered is not reported in the abstract. The outcomes measured were various cardiovascular risk markers, but specific results are not detailed.

Phase: PHASE4Status: TERMINATED
Growth Hormone Deficiency, Empty Sella and Cardio-Metabolic Risk Factors in Obesity: a Cross-Sectional Study.Clinical TrialClinicalTrials.govPublished Mar 1, 2007Added Apr 16, 2026

This study investigated the relationship between growth hormone deficiency, empty sella, and cardio-metabolic risk factors in individuals with obesity. The specific doses of sermorelin administered were not detailed in the abstract. The findings suggest associations but do not establish causation.

Status: COMPLETED
The Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current InsomniaClinical TrialClinicalTrials.govPublished Oct 6, 2016Added Apr 16, 2026

This study investigated the effects of GHRH (Sermorelin) on sleep promotion and endocrine regulation in service members with traumatic brain injury and insomnia. The specific dose and duration were not reported in the abstract. The outcomes measured included various sleep and endocrine parameters.

Phase: PHASE2Status: WITHDRAWN
Effects of Short-term Growth Hormone in HIV-infected PatientsClinical TrialClinicalTrials.govPublished Feb 1, 2009Added Apr 16, 2026

This study investigated the effects of short-term growth hormone administration in HIV-infected patients. The specific dose and duration of treatment were not reported in the abstract. The outcomes measured were not detailed in the abstract.

Phase: NAStatus: COMPLETED
A Multicenter, Double-blind, Randomized, Placebo-controlled Extension Study Assessing the Efficacy and Long-term Safety of a 2 mg Dose of TH9507, a GHRH Analog, in HIV Subjects With Excess Abdominal Fat AccumulationClinical TrialClinicalTrials.govPublished Aug 1, 2007Added Apr 16, 2026

This study assessed the efficacy and long-term safety of a 2 mg dose of TH9507, a GHRH analog, in HIV subjects with excess abdominal fat accumulation. The study was multicenter, double-blind, and randomized, comparing TH9507 to placebo. Specific outcomes were not reported in the abstract.

Phase: PHASE3Status: COMPLETED
Inter-Assay Growth Hormone and IGF-I VariabilityClinical TrialClinicalTrials.govPublished Nov 1, 2007Added Apr 16, 2026

This study evaluated the variability of growth hormone (GH) and insulin-like growth factor I (IGF-I) measurements across different assays. The analysis included participants receiving Sermorelin, although specific details about the population and dosing were not provided. The findings highlight the importance of assay variability in interpreting GH and IGF-I levels.

Status: WITHDRAWN
Semantic Scholar search for SermorelinStudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Growth Hormone-Releasing Hormone Antagonists Increase Radiosensitivity in Non-Small Cell Lung Cancer Cells.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Growth hormone - releasing hormone antagonists induce autophagy in cancer cells.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

External databases

Helpful external resources for additional structural, pharmacologic, and literature context. These are third-party databases; always cross-check details with primary research.

Community notes

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Community research logs (detail)

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Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

Use the "Report side effects" button to open a focused popup form. Please keep descriptions neutral and avoid medical language; think in terms of "nausea", "flushing", "vivid dreams", etc.

Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

58m agoScoring70%

Scored effects for Sermorelin

1d agoRefreshai-researcher85%

Refreshed content for Sermorelin

2d agoRefreshai-researcher85%

Refreshed content for Sermorelin

3d agoRefreshai-researcher85%

Refreshed content for Sermorelin

4d agoRefreshai-researcher85%

Refreshed content for Sermorelin

6d agoRefreshai-researcher85%

Refreshed content for Sermorelin

May 26Scoring70%

Scored effects for Sermorelin

May 26Verificationai-researcher100%

Verified content for Sermorelin: accurate

May 26task_runlibrarian-runner

Completed task: Find real articles for Sermorelin (thin literature)

May 26Ingestiondiscovery

Searched for real articles on Sermorelin

Apr 20Refreshdiscovery50%

Refreshed content for Sermorelin

Apr 20SummaryPubMed20%

Auto-summarized study: "Growth hormone - releasing hormone antagonists induce autophagy in cancer cells...."

Apr 20SummaryPubMed20%

Auto-summarized study: "Growth Hormone-Releasing Hormone Antagonists Increase Radiosensitivity in Non-Sm..."

Apr 20SummarySemanticScholar0%

Auto-summarized study: "Semantic Scholar search for Sermorelin..."

Apr 17Refreshai-researcher85%

Refreshed content for Sermorelin

Apr 16Refreshai-researcher85%

Refreshed content for Sermorelin

Apr 16Refreshai-researcher85%

Refreshed content for Sermorelin