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HCG (Human Chorionic Gonadotropin) record · updated 7h ago

Metabolic & appetiteHealing & recoveryGrade A · human clinicalResearch use only
All 57 studiesJump to the evidenceCompare
What is HCG (Human Chorionic Gonadotropin) used for?

HCG (Human Chorionic Gonadotropin) is a glycoprotein hormone produced by the placenta during pregnancy, structurally similar to luteinizing hormone (LH). It plays a crucial role in regulating reproductive processes in both men and women. In clinical settings, HCG is primarily used to stimulate endogenous testosterone production in men with hypogonadism and to support fertility treatments in women, particularly in assisted reproductive technologies such as in vitro fertilization (IVF).

How it works: LH receptor agonist

Primarily researched for · Metabolic & appetiteRoute · Subcutaneous injection

Development stage

where HCG (Human Chorionic Gonadotropin) sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 147 registered trials. It describes the research record, not a recommendation.

Identity
NameHCG (Human Chorionic Gonadotropin)
Chain length—
Molecular weight321.4 Da
FormulaC11H19N3O6S
Structure typeSmall molecule
ClassMuscle
Research levelFDA Approved
Discovered byCurated master list · 2026

Mass and formula from PubChem CID 4369448. No verified residue count for this compound.

Pharmacology
MechanismLH receptor agonist
RouteSubcutaneous injection
Half-life~24 hours
Time to peak6 hours
DurationVaries
Extraction confidence0.90
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Oct 31, 2026. How this works →
Research stats
Total studies57
Human / animal / cellular35 / 8 / 2
Highest trial phasePhase 3
Years covered2023–2027
Latest study5d ago
Publication history
20232027
Research funding
939 NIH projects · $24.6M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reports12
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

57 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
High-intensity focused ultrasound as a bridging vascular-modulating therapy for fertility-sparing management of placental site trophoblastic tumor complicated by uterine arteriovenous fistula: a case report.
FindingNot reported in abstract.
Human2026Full text read0.80
High-intensity focused ultrasound as a bridging vascular-modulating therapy for fertility-sparing management of placental site trophoblastic tumor complicated by uterine arteriovenous fistula: a case report.
FindingNot reported in abstract.
Human2026Full text read0.80
Combined ovarian tissue cryopreservation and in vitro maturation of ovarian- tissue oocytes (OTO-IVM) for emergency fertility preservation in the early postpartum period: a case report and systematic review of the literature
FindingProlactin was 504.8 mIU/L.
Human2023Full text read0.80
Prediction of Preterm Birth Using the Second-Trimester Quadruple Test
FindingAUC of 0.747 for the four-marker model.
Human2026Full text read0.80
Redefining "Normal" for hCG in postmenopausal women: 97.5th percentile reference intervals and 99th percentile thresholds across four chemiluminescence immunoassay systems.
Finding97.5th percentile RIs were <7.1, <8.2, <5.7, and <5.9 IU/L for Systems A-D.
Human2026Full text read0.80
Case reports of old ectopic pregnancies with intrauterine devices
FindingNot reported in abstract.
Human2026Full text read0.70
Stage-Aware and Explainable Machine Learning for Predicting IVF Implantation
FindingNot reported in abstract.
review2026Full text read0.70
Luteinizing hormone regulates seasonal steroidogenesis locally in the prostate of the muskrat (Ondatra zibethicus).
FindingNot reported in abstract.
Animal2026Full text read0.70
Redefining "Normal" for hCG in postmenopausal women: 97.5th percentile reference intervals and 99th percentile thresholds across four chemiluminescence immunoassay systems.
Finding97.5th percentile RIs were < 7.1, < 8.2, < 5.7, and < 5.9 IU/L for Systems A-D.
Human2027Full text read0.80
First-Trimester Maternal Serum Biomarkers for Prediction of Pre-eclampsia: A Prospective Observational Study
FindingAUC of 0.94 (95% CI 0.89–0.97) for the combination of AFP, PAPP-A, and PlGF.
Human2026Full text read0.90
Predictors of ovarian sensitivity to gonadotropins: a multicentric retrospective investigation of 1,942 women candidates to ART
FindingChronological age negatively correlated with FOI (ρ= -0.145, p value= <0.001, 95% CI from -0.189 to -0.100)
Human2023Full text read0.80
Artificial Intelligence Assisted Blastocyst Assessment Predicts Implantation Success and Demonstrates Concordance with PGT-A Results in Frozen Embryo Transfer Cycles
Finding69.7% of embryos achieved successful implantation, n=340.
Human2023Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching HCG (Human Chorionic Gonadotropin) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much HCG (Human Chorionic Gonadotropin) is discussed should be drawn from it.

Articles mentioning HCG (Human Chorionic Gonadotropin)