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HCG (Human Chorionic Gonadotropin) record · updated 5h ago

Healing & recoveryMetabolic & appetiteGrade A · human clinicalResearch use only
All 45 studiesJump to the evidenceCompare
What is HCG (Human Chorionic Gonadotropin) used for?

HCG (Human Chorionic Gonadotropin) is a glycoprotein hormone produced by the placenta during pregnancy. It is structurally similar to luteinizing hormone (LH) and plays a crucial role in regulating reproductive processes in both men and women. HCG is primarily used in clinical settings to stimulate endogenous testosterone production in men with hypogonadism and to support fertility treatments in women, particularly in assisted reproductive technologies such as in vitro fertilization (IVF).

How it works: LH receptor agonist

Primarily researched for · Healing & recoveryRoute · Subcutaneous injection

Development stage

where HCG (Human Chorionic Gonadotropin) sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 117 registered trials. It describes the research record, not a recommendation.

Identity
NameHCG (Human Chorionic Gonadotropin)
Chain length—
Molecular weight321.4 Da
FormulaC11H19N3O6S
Structure typeSmall molecule
ClassHealing
Research levelFDA Approved
Discovered byCurated master list · 2026

Mass and formula from PubChem CID 4369448. No verified residue count for this compound.

Pharmacology
MechanismLH receptor agonist
RouteSubcutaneous injection
Half-life~24 hours
Time to peak6–24 hours
DurationVaries
Extraction confidence0.80
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Sep 21, 2026. How this works →
Research stats
Total studies45
Human / animal / cellular25 / 7 / 2
Highest trial phasePhase 3
Years covered2023–2026
Latest study5h ago
Publication history
20232026
Research funding
936 NIH projects · $24.9M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reports12
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

45 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Analytical performance comparison of Siemens Atellica CI1900 and Roche Cobas Pure integrated analyzers across spectrophotometric, ion-selective electrode and immunoassay parameters.
FindingR2 ≥ 0.95 for ALT, total bilirubin, glucose, and creatinine in spectrophotometric assays.
review2026Full text read0.90
hCG promotes secondary ovulation and supplementary corpus luteum formation during early pregnancy in mares.
Finding82.4% of hCG-treated mares ovulated within 48 h vs 0% in control, P<0.0001.
Animal2026Full text read0.80
Impact of early postoperative human chorionic gonadotropin change direction after high-intensity focused ultrasound on ultrasound-guided dilation and curettage outcomes in cesarean scar pregnancy: a retrospective study.
Findingβ-hCG on post-curettage day 1 remained higher in the rising group, p<0.05.
Human2026Full text read0.80
Trastuzumab Deruxtecan plus Pertuzumab for HER2-Positive Metastatic Breast Cancer.
TakeawayNot reported in abstract.
—2026Title only0.10
Efficacy of Gonadotropin Therapy to Induce Spermatogenesis and Fertility in Men with Pathologic Gonadotropin Deficiency.
Finding78% achieved >0 million sperm/mL at 5 months.
Human2026Full text read0.80
Impact of early postoperative human chorionic gonadotropin change direction after high-intensity focused ultrasound on ultrasound-guided dilation and curettage outcomes in cesarean scar pregnancy: a retrospective study.
Findingβ-hCG on post-curettage day 1 remained higher in the rising group, p<0.05.
Human2026Full text read0.80
hCG promotes secondary ovulation and supplementary corpus luteum formation during early pregnancy in mares.
Finding82.4% of hCG-treated mares ovulated within 48 h vs 0% in control, P < 0.0001.
Animal2023Full text read0.80
Analytical performance comparison of Siemens Atellica CI1900 and Roche Cobas Pure integrated analyzers across spectrophotometric, ion-selective electrode and immunoassay parameters.
FindingR2 ≥ 0.95 for ALT, total bilirubin, glucose, and creatinine in spectrophotometric assays.
—2026Full text read0.80
Late luteal progesterone as a marker of implantation success rather than its determinant in modified natural cycle single euploid frozen embryo transfer: a prospective multicenter study
Findingβ-hCG day progesterone was significantly higher in patients with ongoing pregnancy [34.4 (IQR 26.4–41.9) vs 12.8 (IQR 9.3–19.1) ng/ml; p<0.001].
Human2026Full text read0.85
Part II. Measuring skin pain in humans: Quantitative, psychophysical, and patient-reported tools for dermatology.
TakeawayStandardizing skin pain measurement tools can improve trial comparability and inform targeted therapy development in dermatology.
review2026Full text read0.80
The value of dynamic contrast-enhanced MRI combined with DWI and the serum β-hCG for assessing villous apoptosis in early tubal pregnancy
FindingROC curve area for combined parameters was 0.982.
Human2026Full text read0.80
Progesterone and hCG in expectant management success in tubal ectopic pregnancy: retrospective single-centre cohort study
FindingMedian P4 in expectant management group 3 nmol/L (IQR 2.00–8.50) vs 17 nmol/L (IQR 5.75–29.25) in surgical/medical management, p=0.0002.
Human2026Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching HCG (Human Chorionic Gonadotropin) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much HCG (Human Chorionic Gonadotropin) is discussed should be drawn from it.

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