Research library

C

grade

Enh13 is essential for starting the male development pathway but not for maintaining male fertility after sex determination in mice.

Not reported in abstract.

summary

C

grade

The study highlights that oocytes matured in vitro show significant proteomic differences compared to those matured in vivo, which may impact their developmental competence.

log2FC of ± 1 and a p-value ≤ 0.05 between in vivo and in vitro maturation systems.

summary

B

grade

Day 1–4 β-hCG percentage change can help identify high-risk patients for methotrexate treatment failure in tubal ectopic pregnancy, but further prospective studies are needed to validate its clinical utility.

Median day 1–4 β-hCG percentage change was +26.4% (IQR 10.9–50.8) in the failure group versus -5.9% (IQR -16.8 to +6.6) in the success group (P<0.001).

summary

B

grade

Preoperative fetal viability and stable HCG dynamics appear to be protective against intrauterine pregnancy loss after surgery for heterotopic pregnancy.

14 (13.73%) experienced miscarriage following surgical treatment, n=102.

summary

C

grade

EZTG shows promise in improving ovarian function in mice through antioxidant pathways, but further research is needed to assess its relevance in humans.

Not reported in abstract.

summary

B

grade

Vaginal estradiol hemihydrate achieved higher serum estradiol levels at lower doses compared to oral estradiol formulations, but clinical pregnancy rates were similar across groups.

Mean serum estradiol levels were highest with vaginal estradiol hemihydrate (701.63 pg/mL), significantly exceeding levels with oral estradiol hemihydrate (331.84 pg/mL; p=0.042).

summary

B

grade

Pleural effusion can be a rare manifestation of severe ovarian hyperstimulation syndrome, requiring prompt management and drainage for patient recovery.

summary

B

grade

In patients with fewer than five oocytes, ICSI does not show a significant advantage over conventional IVF based on embryo and pregnancy outcomes.

Day 3 good quality embryo rate: 59.76% IVF-LN vs 47.46% ICSI-LN; p < 0.01.

summary

B

grade

Immediate ICSI after oocyte denudation may lead to higher fertilization and cleavage rates, but no significant differences in pregnancy outcomes were observed.

80.07% ± 17.09% fertilization rate for immediate ICSI vs 70.80% ± 17.37% for delayed ICSI, mean difference: 9.26, 95% CI 4.40-14.12, p = 0.0003

summary

D

grade

Preterm birth rates in Kazakhstan are projected to stabilize at around 30,000-33,000 cases annually by 2050, highlighting the need for long-term planning in maternal and neonatal health services.

Projected preterm births stabilize at approximately 30,000-33,000 cases annually by 2050.

summary

B

grade

Women with a history of malignant tumors or precancerous lesions may experience lower live birth rates in IVF/ICSI, but multiple cycles can improve opportunities without significantly increasing tumor recurrence risk.

Conservative CLBR for malignant tumors/precancerous lesions plateaued at around 53% after four cycles, n=251.

summary

B

grade

The study suggests that combining postoperative stimulated thyroglobulin and the ps-Tg/TSH ratio may improve risk stratification for patients with papillary thyroid carcinoma after radioactive iodine therapy.

AUC 0.862 for Model 1 vs. AUC 0.614 for Model 2.

summary

B

grade

The study identifies several risk factors for fetal growth restriction and presents a predictive model with moderate capability, but external validation is needed before it can be applied clinically.

Area under the ROC curve of 0.722.

summary

B

grade

Ovulatory disorders are linked to higher clinical pregnancy rates in IUI, but the differences between natural and ovarian stimulation cycles for various infertility types did not consistently show statistical significance.

21.99% clinical pregnancy rate for ovulatory disorder vs 14.15% for normal ovulation, AOR 1.992, 95% CI 1.207-3.288.

summary

C

grade

Pre-synchronization with GnRH or hCG may improve estrus expression and progesterone levels in dairy cows, but the study's limited sample size should be considered.

Estrus expression significantly increased in GnRH+HS and hCG+HS groups compared to HS alone, p<0.001.

summary

B

grade

A deep learning model combining ultrasound and serum biomarkers can predict severe fetal growth restriction with high accuracy, but further validation in broader populations is needed.

AUC of approximately 0.96.

summary