Peptides DB
Research-centric peptide and protocol reference hub

VIP (Vasoactive Intestinal Polypeptide) record · updated 18h ago

Neuro & moodInflammation & immuneGrade A · human clinicalResearch use only
All 40 studiesJump to the evidenceCompare
What is VIP (Vasoactive Intestinal Polypeptide) used for?

Vasoactive Intestinal Peptide | Neuropeptide

How it works: VPAC receptor agonist

Primarily researched for · Neuro & mood

Development stage

where VIP (Vasoactive Intestinal Polypeptide) sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 192 registered trials. It describes the research record, not a recommendation.

Identity
NameVIP (Vasoactive Intestinal Polypeptide)
Chain length—
Molecular weight—
Formula—
Structure type—
ClassNeuro
Research levelModerate Research
Discovered byCurated master list · 2026
Pharmacology
MechanismVPAC receptor agonist
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence0.70
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Oct 10, 2026. How this works →
Research stats
Total studies40
Human / animal / cellular12 / 16 / 3
Highest trial phasePhase 4
Years covered2023–2026
Latest study7d ago
Publication history
20232026
Research funding
449 NIH projects · $29.7M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

40 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Clinical update: Assessment and management of Helicobacter pylori infection.
TakeawayNot reported in abstract.
review2026Title only0.10
Glycine transporter 1 inhibitor, bitopertin, changes excitatory and inhibitory network connectivity in mouse medial prefrontal cortex.
FindingNot reported in abstract.
Animal2026Full text read0.70
Composite pheochromocytoma-ganglioneuroma secreting vasoactive intestinal peptide.
FindingMaximal SUV of 14.4.
Human2026Full text read0.80
Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
TakeawayNot reported in abstract.
Human2026Title only0.10
Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19: In vivo evidence of structural autonomic dysfunction.
Finding2.1 nm/µm³ vs 3.9 nm/µm³ in fundus, P < 0.01
Human2026Full text read0.80
Liangfu Pill Alleviates Constipation-Predominant Irritable Bowel Syndrome through Modulation of 5-HT Signaling Pathway and Gut Microbiota.
FindingP<0.05 or P<0.01 for various measured outcomes.
Animal2026Full text read0.70
Atlas-Guided Cell-Specific Transcriptomics Identifies Pathway-Level Remodeling of Human Hypothalamic CRH Neurons in Opioid Use Disorder
FindingNominal decrease in VIP, not quantified.
Human2026Full text read0.80
Binary classification of sake acidity using excitation-emission matrix fluorescence spectroscopy combined with multivariate analysis models.
FindingAccuracy 0.880.
—2026Full text read0.80
Integrated UHPLC-MS/MS and 16S rRNA sequencing reveals that Weiling Decoction alleviates spleen deficiency with dampness pattern diarrhea by modulating intestinal microbiota.
FindingWLD reduced serum vasoactive intestinal peptide (VIP) levels, p<0.05.
Animal2023Full text read0.70
Safety and efficacy of Meridian sinew tuina (MST) for post-surgical upper limb lymphedema: a systematic review and meta-analysis.
FindingSMD = 1.59; 95% CI: 1.44 to 1.74; Z = 20.81; p < 0.0001; N = 924.
review2026Full text read0.80
Machine learning-guided spectral fingerprinting reveals Parkinson's disease-associated biochemical changes in Drosophila melanogaster.
FindingNot reported in abstract.
Animal2026Full text read0.70
Accuracy and feasibility of robot-assisted implant surgery in edentulous patients: A retrospective case series.
FindingMean linear deviations were 0.71 ± 0.23 mm at the implant neck and 0.74 ± 0.24 mm at the apex.
Human2026Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching VIP (Vasoactive Intestinal Polypeptide) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much VIP (Vasoactive Intestinal Polypeptide) is discussed should be drawn from it.