Research library

D

grade

Not reported in abstract.

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C

grade

Bitopertin alters excitatory and inhibitory connectivity in the mouse mPFC, primarily impacting inhibitory interneurons without significantly inhibiting pyramidal neurons.

Not reported in abstract.

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B

grade

This case highlights a rare occurrence of VIP secretion in a composite pheochromocytoma-ganglioneuroma, with normalization of VIP levels following surgical intervention.

Maximal SUV of 14.4.

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B

grade

Not reported in abstract.

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B

grade

Patients with Long-COVID-19 show reduced cholinergic innervation in the gastric mucosa, which may contribute to dysautonomia.

2.1 nm/µm³ vs 3.9 nm/µm³ in fundus, P < 0.01

summary

C

grade

LFP appears to improve certain symptoms of IBS-C in rat models, potentially through modulation of serotonin signaling and gut microbiota.

P<0.05 or P<0.01 for various measured outcomes.

summary

B

grade

This study highlights changes in the molecular profile of CRH neurons in opioid use disorder, including a decrease in vasoactive intestinal polypeptide, but does not provide direct functional implications.

Nominal decrease in VIP, not quantified.

summary

D

grade

EEM fluorescence spectroscopy combined with PLS-DA shows promise for rapidly classifying sake acidity, but further validation on independent samples is necessary.

Accuracy 0.880.

summary

C

grade

Weiling Decoction may modulate intestinal microbiota and affect gastrointestinal functions in a rodent model of SDDP diarrhea, but the clinical relevance of these findings remains uncertain.

WLD reduced serum vasoactive intestinal peptide (VIP) levels, p<0.05.

summary

A

grade

MST shows promise in reducing upper limb swelling and improving symptoms in patients with breast cancer-related lymphedema, but should not be unconditionally recommended due to potential biases.

SMD = 1.59; 95% CI: 1.44 to 1.74; Z = 20.81; p < 0.0001; N = 924.

summary

C

grade

FT-IR spectroscopy may provide a rapid method to characterize biochemical changes in Parkinson's disease models, but findings from Drosophila may not directly apply to humans.

Not reported in abstract.

summary

B

grade

Robot-assisted implant surgery in edentulous patients showed high accuracy and a 100% implant survival rate, but further randomized controlled trials are needed to confirm these results.

Mean linear deviations were 0.71 ± 0.23 mm at the implant neck and 0.74 ± 0.24 mm at the apex.

summary

B

grade

Non-invasive metabolic profiling shows promise for predicting glioma subtypes, but further validation is needed for clinical use.

IDH prediction AUCs: 0.906 intra-center, 0.857 cross-center.

summary

B

grade

ASCL1 levels are lower in children with COVID-19 compared to those with non-COVID-19 bronchial pneumonia, and it correlates negatively with inflammation markers like neutrophils and CRP.

ACE2 in non-COVID-19 and moderate COVID-19 groups was higher than that in severe groups (p=0.04; p=0.03, respectively).

summary

C

grade

VIP appears to influence myopia progression in guinea pigs by affecting the Wnt/β-catenin signaling pathway, but its relevance to human treatment is unclear.

Not reported in abstract.

summary

C

grade

This study demonstrates that SCN1A gain-of-function mutations can lead to severe epilepsy and premature mortality in mice, with potential lifespan extension observed following treatment with GS967.

100% premature mortality in 64/64 mutant mice between postnatal day 12-18.

summary

C

grade

Hyperspectral imaging combined with chemometrics shows promise for non-destructive analysis of phenolic and flavonoid contents in medicinal plants, but further validation is needed.

R² of 0.996 for flavonoid content prediction.

summary

C

grade

Shenzhuo Formula shows potential in modulating pathways involved in diabetic kidney disease, but human trials are needed to confirm these findings.

Reduced urinary albumin-to-creatinine ratio in db/db mice.

summary

B

grade

CGQSD shows potential in modulating immune pathways in influenza, but clinical relevance requires further investigation.

C4BPB regulation confirmed by ELISA, P=0.0003.

summary

C

grade

XZQF shows potential in reducing migraine-like symptoms in a rat model, but human studies are needed to confirm its efficacy and safety.

XZQF significantly restored body weight and pain thresholds in rats.

summary

C

grade

Mutton fat-processing of Epimedii Folium enhances its anti-osteoporotic effects in preclinical models, suggesting potential benefits in bone health management.

Not reported in abstract.

summary

C

grade

ATR-FTIR spectroscopy combined with machine learning shows promise for estimating time since injury in forensic science, but results from rat models may not apply directly to humans.

R²CV = 0.922, RMSECV = 14.456 h for Ridge regression.

summary

D

grade

Not reported in abstract.

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D

grade

Not reported in abstract.

summary

A

grade

The study found a 41% prevalence of malnutrition in dialysis patients, with eight significant predictors identified for risk assessment. However, existing models have high bias risks that limit their clinical use.

41% pooled prevalence of malnutrition in dialysis patients.

summary