TB-500 (Thymosin Beta-4)

Research-centric overview

Peptide

### Summary TB-500, a synthetic derivative of thymosin beta-4, is a peptide that has garnered attention for its potential role in tissue repair and regeneration. Research into TB-500 is ongoing, particularly regarding its applications in equine medicine and its implications in doping control.

Community effect votes, structured logs, and side-effect summaries.

Effect profile (overview)

Aggregate AI baseline blended with community voting. Hover to inspect effect strengths per category.

Effect scores blend an AI baseline with community votes. Open the full chart to see sliders and vote on each category.

Research log summary heatmap

Compact view of how logs describe shifts in pain, sleep, and performance (−5 to +5). Treat this as qualitative, anonymous signal only.

Pain / discomfort-1/5

Sleep / recovery0/5

Performance / output+4/5

Based on 4 anonymized research logs. Scroll down for full context and methodology.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

No anonymous side-effect reports yet. When reports are submitted, this panel will show a simple heatmap of tags like "nausea", "flushing", "improved healing", and more.

Research footprint

Last analyzed Jun 2, 2026

Studies indexed

Human

Animal

AI analyzed

Evidence mix0% human · 0% animal · 0% cellular · 0% review

Highest phase: Preclinical onlyYears covered: 2012

Librarian pulse — latest actionsFull changelog ↓

Jun 2, 5:00 PMRe-scoredScored effects for TB-500 (Thymosin Beta-4)
Jun 2, 5:00 PMVerifiedVerified content for TB-500 (Thymosin Beta-4): accurate
Jun 1, 6:00 AMRefreshedRefreshed content for TB-500 (Thymosin Beta-4)

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Sequential Dose-Escalation Study of TB-500 (Thymosin Beta 4 17-23 Fragment) in Adults With Stable Atherosclerotic Cardiovascular Disease to Evaluate Safety, Tolerability, Pharmacokinetics, and Exploratory Cardiovascular BiomarkersClinical TrialClinicalTrials.govPublished Feb 5, 2026Added Apr 16, 2026

This study evaluated the safety, tolerability, pharmacokinetics, and exploratory cardiovascular biomarkers of TB-500 (Thymosin Beta 4 17-23 Fragment) in adults with stable atherosclerotic cardiovascular disease. The study was designed as a Phase 1/2, randomized, double-blind, placebo-controlled trial. Specific outcomes and numeric findings are not reported in the abstract.

Phase: PHASE1, PHASE2Status: RECRUITING

Semantic Scholar search for TB-500 (Thymosin Beta-4)StudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential.StudyPubMedPublished Jan 1, 2012Added Dec 12, 2025

Not reported in abstract.

Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry.StudyPubMedPublished Jan 1, 2012Added Dec 12, 2025

This study provides methods for detecting TB-500 in equine urine and plasma, which is important for doping control, but lacks detailed results.

External databases

Helpful external resources for additional structural, pharmacologic, and literature context. These are third-party databases; always cross-check details with primary research.

Community notes

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Community research logs (detail)

Showing the latest 4 logs out of 4.

Goal: injury / tissue repair

Context: unspecified training level • age not given

Duration not specified

Δ scores

Pain +0Sleep +3Perf +5

Goal: injury / tissue repair

Context: unspecified training level • age not given

Duration not specified

Δ scores

Pain -5Sleep +0Perf +5

Goal: injury / tissue repair

Context: unspecified training level • age not given

Duration not specified

Δ scores

Pain +0Sleep -4Perf +5

Goal: injury / tissue repair

Context: unspecified training level • age not given

Duration not specified

Δ scores

Pain +0Sleep +0Perf +0

How to read these logs

Each entry is a single, anonymized “n=1” summary with relative change sliders from −5 to +5. Higher positive values indicate perceived improvement; negative values indicate perceived worsening.

Context (training level, age band, duration, and dosing frequency) is shown so you can quickly skim for patterns or outliers. Treat this as qualitative signal layered on top of study data, not as a substitute for controlled trials.

Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

Use the "Report side effects" button to open a focused popup form. Please keep descriptions neutral and avoid medical language; think in terms of "nausea", "flushing", "vivid dreams", etc.

Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

1h agoScoring70%

Scored effects for TB-500 (Thymosin Beta-4)

1h agoVerificationai-researcher90%

Verified content for TB-500 (Thymosin Beta-4): accurate

1d agoRefreshai-researcher85%

Refreshed content for TB-500 (Thymosin Beta-4)

2d agoRefreshai-researcher85%

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3d agoRefreshai-researcher85%

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4d agoRefreshai-researcher85%

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6d agoRefreshai-researcher85%

Refreshed content for TB-500 (Thymosin Beta-4)

May 26Scoring70%

Scored effects for TB-500 (Thymosin Beta-4)

May 26task_runlibrarian-runner

Completed task: Find real articles for TB-500 (Thymosin Beta-4) (thin literature)

May 26Ingestiondiscovery

Searched for real articles on TB-500 (Thymosin Beta-4)

May 26Refreshai-researcher85%

Refreshed content for TB-500 (Thymosin Beta-4)

Apr 20Refreshdiscovery50%

Refreshed content for TB-500 (Thymosin Beta-4)

Apr 20SummarySemanticScholar0%

Auto-summarized study: "Semantic Scholar search for TB-500 (Thymosin Beta-4)..."

Apr 17Refreshai-researcher85%

Refreshed content for TB-500 (Thymosin Beta-4)

Apr 16Refreshai-researcher85%

Refreshed content for TB-500 (Thymosin Beta-4)