Peptides DB
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Grade B · human evidence, early4 peptides · 110 studies

Neurocognitive & mood exploration

Exploratory protocol sketch for Selank, Semax, DSIP, and Oxytocin in cognition, sleep, and affect.

This is a description, not a protocol to follow

Everything below is a summary of what people report doing and what the literature contains. Nothing here is medical advice.

What the evidence actually supports

Supported in animals
Animal-model studies indexed · 25
Cell and in-vitro studies indexed · 8
Reviews and uncategorised studies · 19
Not established
Any effect in humans · 58 human studies indexed
Any benefit from combining them · no combination study in our index
Human dose, route or duration · no PK study indexed

Protocol details

The combination of Selank, Semax, DSIP, and Oxytocin has not been studied together in published research. The available studies focus on each compound separately, providing insights into their individual effects and potential applications. Oxytocin has been investigated in various contexts, including its role in maternal health and stress response. One study found that salivary oxytocin levels increased during the observation of a stressed partner, suggesting a link between oxytocin and empathic stress responses in humans [3]. Another study indicated that oxytocin administration could enhance attention to social stimuli in men [16]. Additionally, oxytocin was shown to influence labor outcomes, with intrauterine administration significantly reducing blood loss during cesarean delivery [14]. DSIP has been explored in relation to chronic stress and motivation, revealing a U-shaped relationship where both low and high stress levels may enhance motivation, while moderate stress could reduce it [20]. However, there are no studies that specifically examine DSIP's effects in conjunction with the other compounds in this protocol. Semax has been studied in various clinical contexts, but the indexed studies do not provide specific findings related to neurocognitive or mood effects. The research primarily focuses on its application in other medical conditions, and no evidence exists regarding its use alongside the other peptides in this protocol. Overall, while individual studies provide insights into the effects of Oxytocin and DSIP, there is no evidence to support the efficacy or interactions of the combination of Selank, Semax, DSIP, and Oxytocin. Further research would be necessary to explore the potential benefits of this specific combination. Sources [3] Salivary oxytocin and testosterone in empathic stress responding: a pilot study. — Stress (Amsterdam, Netherlands), 2026 https://doi.org/10.1080/10253890.2026.2720481 [14] The Effect of Intrauterine Oxytocin-Soaked Gauze on Postoperative Bleeding in Cesarean Section: A Double-Blind Randomized Clinical Trial — 2026 https://doi.org/10.21203/rs.3.rs-10831568/v1 [16] Oromucosal administration of oxytocin and its receptor antagonist atosiban respectively increase and decrease preferential attention to dynamic social stimuli in men — 2026 https://doi.org/10.64898/2026.09.08.26362314 [20] A U-shaped relationship between perceived chronic stress and the approach motivation: evidence from resting-state EEG. — Stress (Amsterdam, Netherlands), 2026 https://doi.org/10.1080/10253890.2026.2720484

Research & studies for this protocol

110 rows · showing 24
Newest first
StudyCompoundSourceYear
This study investigated risk factors for caesarean section (CS) during delivery in women with pre-eclampsia. A total of 627 women were included, and a predictive scoring model was developed. The model demonstrated an area under the curve (AUC) of 0.601 for predicting the need for CS.Oxytocinbiorxiv-preprint2026
This study investigates the transcriptional programs of the human myometrium during pregnancy, focusing on smooth muscle and endothelial cell subtypes. It analyzes samples from 15 patients collected during cesarean delivery, revealing insights into uterine function and complications like uterine atony. The findings highlight the role of FSH signaling and changes in actin architecture in the context of labor and postpartum hemorrhage.Oxytocinbiorxiv-preprint2023
The study measured the effects of cervical balloon placement time on labor duration and maternal outcomes in 193 pregnant women. The women were divided into two groups based on balloon placement before or after 12:00. Significant differences were observed in labor progression and postpartum hemorrhage rates between the groups.Oxytocinbiorxiv-preprint2026
This study investigated the brain of a 57-year-old woman with a >30-year history of winter-associated hypothermia and neuroendocrine instability. Postmortem analysis revealed profound neurochemical abnormalities, including near-complete loss of immunoreactivity for key neuropeptides. The findings suggest selective hypothalamic and microglial suppression in this rare human hibernation-like phenotype.Oxytocineuropepmc2023
Delta-sleep-inducing peptide (DSIP)-like material was detected in human breast milk of two women. The concentration in colostrum was 30 ng/ml, decreasing to about 10 ng/ml in milk over two months. A circadian rhythm of DSIP was observed in one woman, with peaks in the afternoon and troughs in the morning.DSIPPubMed1984
This study measured plasma delta-sleep-inducing peptide (DSIP) levels in 12 normal volunteers over 24 hours. The researchers found a diurnal rhythm with maximum levels at 1500 h and minimum at 0100 h. DSIP levels were lower during rapid eye movement sleep and somewhat lower during slow wave sleep compared to awake values.DSIPPubMed1994
This study measured the impact of thyroid hormone excess targeted to oxytocin neurons in a mouse model. It found that T3 excess led to significant deficits in oxytocin physiology without affecting behavior. The study highlights the relationship between thyroid hormone and oxytocin gene regulation.Oxytocineuropepmc2026
This study compared labor induction characteristics and delivery outcomes in individuals with BMI < 40 kg/m² versus ≥ 40 kg/m² undergoing induction at term. Vaginal misoprostol was administered in 25 µg doses every three hours for up to five doses. The study found that individuals with severe obesity had longer labor durations and lower odds of vaginal delivery.Oxytocineuropepmc2026
This study measured the bromatological composition of colostrum and milk in bitches with hypogalactia after elective caesarean section, treated with domperidone and/or oxytocin. Twenty bitches were assigned to four treatment groups: Oxytocin, Domperidone, Oxytocin + Domperidone, and Control. Results indicated variations in milk composition, particularly in protein, fat, and carbohydrate content, depending on the treatment protocol.Oxytocineuropepmc2026
A portable electrochemical sensing platform was developed for ultrasensitive detection of oxytocin in maternal serum. The sensor achieved a low detection limit of 1.15 pg/mL and a linear range of 10 - 1000 pg/mL. Clinical serum samples showed strong agreement with ELISA results (r > 0.95).Oxytocineuropepmc2026
This study measured salivary oxytocin and testosterone levels in 108 opposite-sex dyads during a psychosocial stressor. Oxytocin increased by 16.64% and testosterone by 23.00% during the observation of a stressed partner. The findings suggest a link between oxytocin reactivity and stress resonance, while testosterone showed a negative association with stress resonance.Oxytocineuropepmc2026
This study measured the effects of oxytocin on VTA dopaminergic neurons in PTSD model rats. The research involved graded intracerebroventricular OXT infusions and OXTR antagonist pretreatment. The findings indicated that while baseline firing rates were lower in PTSD model rats, oxytocin elevated neuronal excitability in both PTSD and control groups.Oxytocineuropepmc2026
This study examined the relationship between peripheral oxytocin receptor gene promoter DNA methylation (OXTR DNAm) and brain structural connectivity in 563 patients with panic disorder (PD) compared to 210 healthy controls. Patients with PD exhibited significantly lower OXTR DNAm levels than healthy controls. Reduced OXTR DNAm was negatively correlated with elevated clinical symptom scores in patients with PD.Oxytocineuropepmc2026
This study investigated the effects of chemogenetic activation of hypothalamic oxytocin neurons on face exploration in macaques. The activation redirected gaze toward the eyes during face exploration tasks. The findings suggest a link between oxytocin neuron activity and social visual orienting behaviors.Oxytocinbiorxiv-preprint2026
This study evaluated oxytocin-induced perfusion changes in uterine fibroids in 55 patients using contrast-enhanced ultrasound (CEUS) and assessed their predictive value for high-intensity focused ultrasound (HIFU) ablation efficacy. Patients received an intravenous oxytocin infusion at a dose of 0.10 U/ml over 10 minutes. The findings indicated significant differences in perfusion parameters between groups based on ablation efficacy.Oxytocineuropepmc2026
This study evaluated the effect of intrauterine oxytocin-soaked gauze on blood loss and hemodynamic stability in 120 women undergoing elective cesarean delivery. The oxytocin group demonstrated lower intraoperative blood loss compared to saline and control groups. No significant differences in heart rate or serious adverse events were observed.Oxytocinbiorxiv-preprint2026
This systematic review examined 11 original human studies focusing on epigenetic mechanisms related to perinatal depression, particularly DNA methylation and histone alterations. Key findings included associations between NR3C1/NR3C2 methylation and maternal depressive symptoms, as well as oxytocin-dependent CRY1/CRY2 methylation linked to mood and anxiety symptoms. The study emphasizes the need for longitudinal research to validate biomarkers and clarify causality.Oxytocinbiorxiv-preprint2026
This study measured the effects of oromucosal administration of oxytocin and atosiban on social attention in 250 adult male subjects. A dose of 48 IU of oxytocin significantly increased preferential viewing of social stimuli compared to placebo, while atosiban decreased this preference. Blood samples were collected to measure oxytocin concentrations pre- and post-treatment.Oxytocinbiorxiv-preprint2026
This systematic review examined the role of epigenetic mechanisms in perinatal depression, focusing on maternal-fetal stress and hormonal pathways. It analyzed 11 original human studies primarily assessing DNA methylation and histone modifications. The review found associations between NR3C1/NR3C2 methylation and maternal depressive symptoms, as well as oxytocin-dependent CRY1/CRY2 methylation with mood and anxiety symptoms.Oxytocinbiorxiv-preprint2026
This systematic review evaluated the efficacy of drugs aimed at reducing uterine contractions in individuals with primary dysmenorrhea. A total of 447 participants across 25 trials were analyzed, focusing on various pharmacologic therapies compared to placebo. Nonsteroidal anti-inflammatory drugs (NSAIDs) were found to consistently reduce menstrual pain and uterine contractions.Oxytocineuropepmc2026
This study validated a VSV-based pseudovirus system for assessing SARS-CoV-2 neutralization using the monoclonal antibody BD-604. The assay was optimized for a multiplicity of infection (MOI) of 0.25 and demonstrated specific neutralizing activity against several SARS-CoV-2 variants. The limit of quantification was established at 125 ng of mAb BD-604.DSIPeuropepmc2026
This study measured the relationship between chronic stress and resting-state EEG measures of approach motivation in sixty undergraduate students. Significant quadratic associations were found between perceived stress and EEG measures, including alpha frontal asymmetry, delta power, and theta power. The findings suggest a U-shaped relationship, where both low and high chronic stress levels enhance approach motivation.DSIPeuropepmc2026
This study investigates the impacts of beaver population changes on the livelihoods and wellbeing of Inuvialuit communities in the western Canadian Arctic. Interviews were conducted with 25 Inuvialuit knowledge holders from Inuvik, Tuktoyaktuk, and Aklavik. The findings highlight disruptions in subsistence harvesting and increased risks for active harvesters.DSIPeuropepmc2026
This study developed a prediction model for Category II and III fetal heart rate patterns in 237 parturients undergoing labor epidural analgesia. The model identified 11 predictors, including maternal temperature and oxytocin dosage, with an AUC of 0.800. The nomogram was internally validated and showed good discrimination and calibration.Oxytocineuropepmc2026