Grade B · human evidence, early4 peptides · 36 studies
Neurocognitive & mood exploration
Exploratory protocol sketch for Selank, Semax, DSIP, and Oxytocin in cognition, sleep, and affect.
This is a description, not a protocol to follow
Everything below is a summary of what people report doing and what the literature contains. Nothing here is medical advice.
What the evidence actually supports
Supported in animals
Animal-model studies indexed · 8
Cell and in-vitro studies indexed · 2
Reviews and uncategorised studies · 9
Not established
Any effect in humans · 17 human studies indexed
Any benefit from combining them · no combination study in our index
Human dose, route or duration · no PK study indexed
Protocol details
Published research has not tested the combination of Selank, Semax, DSIP, and Oxytocin together. The available studies focus on each compound individually, with no evidence indicating their effects when used in conjunction.
For Semax, studies have explored its effects on intracellular calcium dynamics in rat brain neurons, although specific results were not reported in the abstract [6]. Other research investigated its role in modulating anti-inflammatory cytokine expression in acute spinal cord injury models in male Sprague Dawley rats, but again, detailed findings were not provided [7].
Selank has been studied in various contexts, including a randomized clinical trial related to colorectal cancer, but the abstract did not report specific outcomes [8]. Additionally, observational studies have looked at its efficiency in packed red blood management for brain tumor resection, with no detailed results available [10].
Oxytocin has been examined in relation to maternal health and emotional responses in cancer patients, but the abstracts of these studies did not disclose specific findings [11][13]. DSIP has been investigated for its potential effects in mouse models of insomnia, but results were not detailed in the abstract [15].
Overall, while individual studies exist for each peptide, there is no evidence from published trials that establishes the effects of this specific combination of peptides on neurocognitive and mood exploration.
Sources
[6] The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons. — 2025 https://pubmed.ncbi.nlm.nih.gov/41171324/
[7] Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats). — 2023 https://pubmed.ncbi.nlm.nih.gov/41179234/
[8] Effect of perioperative ONS combined with intestinal microecology in patients with colorectal cancer: a randomized clinical trial. — 2025 https://pubmed.ncbi.nlm.nih.gov/40497027/
[10] Efficiency in packed red blood management for brain tumor resection: multicentre prospective cohort study (TScoreBTR). — 2022 https://pubmed.ncbi.nlm.nih.gov/40901795/
[11] Oxytocin administration during labor does not affect maternal serum oxytocin levels, early postpartum breastfeeding attitude and maternal attachment. — 2025 https://pubmed.ncbi.nlm.nih.gov/41348825/
[13] "Anxiety and worry" induces fear transformation in cancer patients: an evidence-based exploration and theoretical consideration of the emotional evolution in tumor patients. — 2025 https://pubmed.ncbi.nlm.nih.gov/41350747/
[15] Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models. — 2024 https://pubmed.ncbi.nlm.nih.gov/39444618/
Research & studies for this protocol
36 rows · showing 24Newest first
| Study | Compound | Source | Year |
|---|---|---|---|
| This study investigated the effects of Limosilactobacillus reuteri (LR) supplementation on socioemotional behavior in C57BL/6N mouse offspring exposed to polybrominated diphenyl ethers (PBDEs). Offspring were supplemented with LR during development, and various behavioral and biological outcomes were measured. The study found that LR treatment normalized certain behavioral deficits and altered thyroid hormone signaling in a sex-dependent manner. | Oxytocin | biorxiv-preprint | 2026 |
| This study evaluated the impact of a policy change recommending the cessation of oxytocin during the active phase of induced labor. It compared outcomes from 600 women before the policy implementation with 556 women after. No significant change in caesarean delivery rates was observed, although maternal satisfaction scores decreased modestly. | Oxytocin | biorxiv-preprint | 2026 |
| This study assessed the feasibility of a randomized controlled trial comparing halved versus routine-concentration oxytocin infusion during the active phase of labor in women undergoing induction. A total of 293 women consented to participate, with 101 being randomized. No significant differences in maternal or neonatal outcomes were reported. | Oxytocin | biorxiv-preprint | 2026 |
| This study reports the discovery of inhibitors targeting the TRF1:TIN2 protein interaction, which is essential for the recruitment of TRF1 to the shelterin complex. The binding affinity of the lead compound (compound 40) to TRF1 was measured at a K<sub>D</sub> of 29 µM. Additionally, the compound demonstrated an IC<sub>50</sub> of 67 µM in displacing a TIN2 probe. | DSIP | europepmc | 2025 |
| This study evaluated the willingness to pay (WTP) for sanitation services in low-income communities of Dhaka, Bangladesh, comparing contingent valuation (CVM) and hedonic pricing (HPM) methods. A total of 1000 households were surveyed, revealing a mean WTP of BDT 87 for CVM and BDT 74 for HPM. The findings indicate significant socioeconomic influences on WTP. | DSIP | europepmc | 2026 |
| This systematic review investigates the efficacy and safety of locally applied otoprotective agents other than sodium thiosulfate (STS) to prevent cisplatin-induced hearing loss (CIHL) in pediatric cancer patients. It includes findings from 70 preclinical and eight clinical studies, focusing on agents like dexamethasone and N-acetylcysteine. The review highlights the challenges of implementing local STS and the need for further research. | Oxytocin | europepmc | 2026 |
| This study measured vaginal delivery outcomes and factors influencing emergency cesarean section (EmCS) among 894 pregnant women with hypertensive disorders of pregnancy (HDP). The success rate of vaginal delivery ranged from 85.1% to 90.8% across different classifications of HDP. Notably, chronic hypertension was identified as a significant risk factor for poorly controlled blood pressure during labor. | Oxytocin | europepmc | 2026 |
| This qualitative study explored midwives' experiences and interpretations of obstetric violence in delivery room settings. Conducted with ten midwives from two public hospitals in Spain, the study utilized semi-structured interviews to gather insights on perceived causes and contextual conditions. No numeric findings were reported in the abstract. | Oxytocin | europepmc | 2026 |
| This pilot randomized controlled trial evaluated the effect of a single 2,000 mg oral dose of calcium carbonate on uterine contractility in term patients with a singleton fetus. The study found no statistically significant improvement in uterine contractility or clinical outcomes compared to the control group. The findings suggest limited physiological effects of oral calcium on uterine activity. | Oxytocin | europepmc | 2026 |
| This study assessed the availability and implementation of practices for postpartum hemorrhage (PPH) and hypertensive disorders of pregnancy (HDP) across 31 countries. Oxytocin was reported as regularly available in public facilities by 77% of countries and in private facilities by 84% of countries. The study highlights gaps in the integration of certain interventions and quality assurance systems. | Oxytocin | PubMed | 2026 |
| This pilot randomized controlled trial evaluated the effect of a single 2,000 mg oral dose of calcium carbonate on uterine contractility in term patients with singleton fetuses. The study measured uterine activity using Montevideo units (MVUs) at baseline and at 30-minute intervals for two hours. No statistically significant improvement in uterine contractility or clinical outcomes was observed. | Oxytocin | PubMed | 2026 |
| This study evaluated the local and transboundary impacts on PM2.5 source contributions in Seoul, Korea during the early COVID-19 outbreak from January to March 2020. The analysis compared PM2.5 concentrations and source contributions to similar periods in 2019. Significant reductions in PM2.5 concentrations were observed, with various sources showing decreased contributions. | DSIP | biorxiv-preprint | 2022 |
| This study investigated the effects of ACTH4-10 (Semax) on anti-inflammatory cytokine expression in male Sprague Dawley rats following acute spinal cord injury (SCI). The treatment group received intranasal ACTH4-10, while the control group received a placebo. Results indicated increased levels of IL-10 and IL-13 in the treatment group at various time points post-injury. | Semax | biorxiv-preprint | 2025 |
| This pilot study measured the effects of 24 IU intranasal oxytocin combined with mindfulness-based group therapy (MBGT) on negative symptoms in individuals with schizophrenia spectrum disorders (SSD). A total of 47 participants were randomized to receive either oxytocin or placebo before four therapy sessions. The study reported significant improvements in negative symptoms for the oxytocin group compared to placebo, but the clinical significance of these findings remains unclear. | Oxytocin | biorxiv-preprint | 2026 |
| This study investigated the effects of oxytocin receptor (OTR) blockade during critical neurodevelopmental periods in rats, specifically focusing on pain hypersensitivity and cognitive deficits. Control rats received daily injections of the selective OTR antagonist d(CH2)5-Tyr(Me)-[Orn8]-vasotocin (dOVT) from postnatal days 2-12. The findings indicated that OTR dysfunction may contribute to nociceptive and cognitive consequences of early life stress. | Oxytocin | biorxiv-preprint | 2026 |
| This study measured the effects of neonatal oxytocin (OT) administration on spatial memory deficits induced by neonatal maternal separation (NMS) in male Sprague-Dawley rat pups. The intervention involved intraperitoneal OT injections during the neonatal period, followed by assessments of memory and synaptic plasticity in adulthood. The findings indicated that OT completely prevented spatial memory deficits in NMS males. | Oxytocin | biorxiv-preprint | 2026 |
| This pilot clinical study evaluated a digitally guided protocol combining a hybrid maxillary expander and supragingival mandibular miniplates in ten late adolescents (mean age 16.0 ± 1.3 years) with skeletal Class III malocclusion. The study reported significant maxillary advancement after 12 months of treatment. No significant changes were noted in the mandibular position or angle. | Semax | PubMed | 2026 |
| This study investigated the effects of nitrogen (N) addition on the nutrient allocation and resorption trade-offs in Populus koreana across 12 randomized plots with four N treatments: 0, 4, 8, and 16 g N·m⁻²·yr⁻¹. The findings indicate significant increases in soil total organic carbon and total nitrogen, alongside changes in phosphorus dynamics and nutrient resorption efficiencies. No therapeutic claims are made. | Selank | PubMed | 2026 |
| This study evaluated nutrient limitation in 56 wadeable streams across Wisconsin, focusing on nitrogen (N) and phosphorus (P) concentrations. The findings indicated that 41% of sites showed no limitation, while 23% were N-limited, 20% co-limited by N and P, and 9% were P-limited. The study identified ambient total N thresholds for a 50% probability of N limitation at 1.37-1.93 mg/L. | Selank | PubMed | 2026 |
| This study examines the sexually dimorphic population of oxytocin receptor (OXTR) neurons in the anteroventral periventricular nucleus (AVPV) of female mice. It reports that the expression of OXTR is estrogen-dependent and increases during the postpartum period, impacting maternal behavior. The study identifies that approximately 30% of AVPV-OXTR neurons are immunoreactive to tyrosine hydroxylase, suggesting a dopaminergic role. | Oxytocin | PubMed | 2026 |
| Not reported in abstract. | DSIP | SemanticScholar | 2010 |
| Not reported in abstract. | Semax | SemanticScholar | 2010 |
| Not reported in abstract. | Selank | SemanticScholar | 2010 |
| Not reported in abstract. | Oxytocin | SemanticScholar | 2010 |