Peptides DB

Research-centric peptide and protocol reference hub

Semax

Research-centric overview

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### Summary Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH) that has been investigated for its potential neuroprotective and cognitive-enhancing effects. Research suggests that Semax may influence various biological pathways, including neuroinflammation and intracellular calcium dynamics.

Community effect votes, structured logs, and side-effect summaries.

Effect profile (overview)

Aggregate AI baseline blended with community voting. Hover to inspect effect strengths per category.

Effect profile (AI + community): Healing & recovery 1.0/5 · Neuro & mood 4.0/5 · Inflammation & immune 2.0/5Healing 1.0Muscle 0.0Metabolic 0.0Neuro 4.0Sleep 0.0Inflammation 2.0Skin 0.0

Effect scores blend an AI baseline with community votes. Open the full chart to see sliders and vote on each category.

Research log summary heatmap

Compact view of how logs describe shifts in pain, sleep, and performance (−5 to +5). Treat this as qualitative, anonymous signal only.

No community research logs yet. When structured logs are added, this panel will summarize typical shifts in pain, sleep, and performance.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

No anonymous side-effect reports yet. When reports are submitted, this panel will show a simple heatmap of tags like "nausea", "flushing", "improved healing", and more.

Research footprint

Last analyzed Jun 2, 2026
6
Studies indexed
0
Human
2
Animal
6
AI analyzed
Evidence mix0% human · 33% animal · 0% cellular · 0% review
Highest phase: PreclinicalYears covered: 2026
Librarian pulse — latest actionsFull changelog ↓
  • Jun 2, 5:00 PMRe-scoredScored effects for Semax
  • May 28, 6:01 AMRefreshedRefreshed content for Semax
  • May 27, 6:03 AMRefreshedRefreshed content for Semax

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

Semantic Scholar search for SemaxStudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseases.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.StudyPubMedAdded Dec 12, 2025

The study explores Semax's effects on calcium dynamics in rat neurons, but specific results are not available in the abstract.

Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats).StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

External databases

Helpful external resources for additional structural, pharmacologic, and literature context. These are third-party databases; always cross-check details with primary research.

Community notes

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Community research logs (detail)

No community research logs yet. Use the “Contribute data” button above to share an anonymized summary of your experience.

Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

Use the "Report side effects" button to open a focused popup form. Please keep descriptions neutral and avoid medical language; think in terms of "nausea", "flushing", "vivid dreams", etc.

Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

57m agoScoring70%

Scored effects for Semax

5d agoRefreshai-researcher85%

Refreshed content for Semax

6d agoRefreshai-researcher85%

Refreshed content for Semax

May 26Scoring70%

Scored effects for Semax

May 26task_runlibrarian-runner

Completed task: Find real articles for Semax (thin literature)

May 26Ingestiondiscovery

Searched for real articles on Semax

Apr 20Refreshdiscovery50%

Refreshed content for Semax

Apr 20SummarySemanticScholar0%

Auto-summarized study: "Semantic Scholar search for Semax..."