Peptides DB
Research-centric peptide and protocol reference hub

DSIP record · updated 18h ago

Sleep & circadianNeuro & moodGrade B · human evidenceResearch use only
All 27 studiesJump to the evidenceCompare
What is DSIP used for?

Delta Sleep-Inducing Peptide (DSIP) is a neuropeptide that has garnered attention for its potential roles in sleep regulation, stress modulation, and pain management. It is primarily known for promoting sleep and improving sleep quality, which is critical for overall health. DSIP has been shown to influence various physiological processes, including the modulation of neurotransmitter release and the regulation of hormonal systems, particularly those involved in stress responses.

How it works: CNS action, enhances slow-wave sleep

Primarily researched for · Sleep & circadian

Development stage

where DSIP sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 89 registered trials. It describes the research record, not a recommendation.

Identity
NameDSIP
Chain length9 amino acids
SequenceWAGGDASGE
Molecular weight848.8 Da
FormulaC35H48N10O15
Structure typePeptide
ClassSleep
Research levelPreclinical
Discovered byAdded before provenance tracking · 2025

Mass and formula from PubChem CID 68816. The chain length is only shown where the residues account for that mass, so a figure here has been checked against it rather than taken on trust.

Pharmacology
MechanismCNS action, enhances slow-wave sleep
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence0.70
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Sep 9, 2026. How this works →
Research stats
Total studies27
Human / animal / cellular10 / 5 / 7
Highest trial phasePreclinical
Years covered2010–2026
Latest study1mo ago
Publication history
20102026
Research funding
13 NIH projects · $564k awarded · through FY2017
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

27 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Validation of SARS-CoV-2 neutralization assay using VSV-based pseudovirus system.
FindingLimit of quantification (LOQ) was determined to be 125 ng of mAb BD-604.
In vitro2026Full text read0.80
A U-shaped relationship between perceived chronic stress and the approach motivation: evidence from resting-state EEG.
Findingβ = 0.33, 95% CI [0.0003, 0.0036], p = 0.021 for delta power.
Human2026Full text read0.80
'<i>In Every River, in Every Lake</i>': Impacts of Beaver Population Change on Indigenous Livelihoods and Wellbeing in the Inuvialuit Settlement Region, Western Canadian Arctic.
TakeawayBeaver population changes are impacting Inuvialuit livelihoods and wellbeing, highlighting the complex interplay between ecological and social factors.
Human2026Full text read0.70
Comprehensive security review and challenges for smart and power grids to prevent cyber-attacks in IoTs.
TakeawayEnsuring Quality of Service in Smart Grid communication technologies is essential to address security vulnerabilities and enhance system reliability.
review2026Full text read0.80
Design, synthesis, and evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates for enhanced photodynamic therapy in triple-negative breast cancer.
FindingIC50 values of 51.16 ± 1.93 μM and 49.65 ± 2.50 μM for conjugates 13a and 13d.
In vitro2026Full text read0.80
Evaluation of carotid intima-media thickness and ultrafast pulse wave velocity for cardiovascular events and all-cause mortality in hemodialysis patients: impact of diabetes.
FindingCIMT in MHD patients was 1.60 mm vs 0.80 mm in non-ESRD controls, p=0.004.
Human2026Full text read0.80
Genome-wide identification and expression profiling of HSD3B and SDR42E1 genes in the Pacific oyster (Crassostrea gigas): potential associations with gonadal development.
FindingNot reported in abstract.
In vitro2026Full text read0.70
Biosensing technologies for cannabinoid monitoring in pain management: Current methods, clinical needs, and translational challenges.
TakeawayPortable electrochemical sensors and compact optical platforms may soon be useful for cannabinoid monitoring, but many technologies still need validation in real patient samples.
review2026Full text read0.80
EFS-NET: EEG-fNIRS multi-scale fusion network based on spatial calibration.
Finding81.69 ± 9.49% classification accuracy on Mental Arithmetic dataset.
review2023Full text read0.70
Noninvasive assessment of Doppler-derived estimated fetal interatrial pressure-gradient indices using ductus venosus and pulmonary vein velocities in late-onset fetal growth restriction: a prospective case-control study.
FindingPulmonary vein D-wave velocity was significantly reduced in FGR fetuses (18.20 [IQR 13.43-22.40] vs. 20.90 [IQR 15.97-25.60] cm/s; p=0.021).
Human2026Full text read0.80
Ginkgo biloba extract 50 alleviates memory and synaptic plasticity deficits by inhibiting neuroinflammation via the blockage of ATP-P2X7R axis in presenilin 1/2 conditional double knockout mice.
FindingNot reported in abstract.
Animal2026Full text read0.80
Diverse binding poses of agonistic neurotoxins on human Na(v)1.6.
FindingNot reported in abstract.
In vitro2026Title only0.20

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching DSIP will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much DSIP is discussed should be drawn from it.

Articles mentioning DSIP