Peptides DB
Research-centric peptide and protocol reference hub

Oxytocin record · updated 17h ago

Neuro & moodHealing & recoveryGrade A · human clinicalResearch use only
All 30 studiesJump to the evidenceCompare
What is Oxytocin used for?

Oxytocin is a neuropeptide that plays a crucial role in social bonding, reproductive behaviors, and emotional regulation. Its functions extend to various physiological processes, including childbirth and lactation, and it has garnered interest for its potential therapeutic applications in mental health and social disorders.

How it works: Oxytocin receptor agonist

Primarily researched for · Neuro & moodRoute · Intravenous injection, intranasal administration

Development stage

where Oxytocin sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 95 registered trials. It describes the research record, not a recommendation.

Identity
NameOxytocin
Chain length9 amino acids
Molecular weight1,007.2 Da
FormulaC43H66N12O12S2
Structure typePeptide
ClassNeuro
Research levelFDA Approved
Discovered byAdded before provenance tracking · 2025

Mass and formula from PubChem CID 439302. The chain length is only shown where the residues account for that mass, so a figure here has been checked against it rather than taken on trust.

Pharmacology
MechanismOxytocin receptor agonist
RouteIntravenous injection, intranasal administration
Half-life~3–5 min
Time to peak~30 min
Duration~2–4 hours
Extraction confidence0.90
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Aug 31, 2026. How this works →
Research stats
Total studies30
Human / animal / cellular15 / 8 / 1
Highest trial phasePhase 2
Years covered2010–2026
Latest study17h ago
Publication history
20102026
Research funding
4,786 NIH projects · $25.2M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reports2,682
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

30 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Associations between high perceived stress, inflammatory proteins, and BDNF: a cross-sectional study of young adult females in Shanghai, China.
Finding4E-BP1 log2FC = 0.565 in high perceived stress group.
Human2026Full text read0.70
Sex differences in DNA demethylation machinery precede sex differences in the oxytocinergic system in the postnatal mouse brain
FindingNot reported in abstract.
Animal2026Full text read0.70
Single-Cell Mapping of Malignant Signaling Networks Guides Drug Combinations
FindingNot reported in abstract.
In vitro2026Full text read0.80
Geographical inequalities and factors associated with emergency obstetric and newborn care readiness in Ethiopia: a national Bayesian spatial analysis
FindingMean CERI was 57.4 (SE 2.6).
Human2026Full text read0.80
Integrating Heat-Stable Carbetocin into Routine Maternal Care: Lessons from District-wide Implementation of an AMTSL Strengthening Model in India
Finding200 PPH cases (0.48%) among women receiving HSC prophylaxis.
Human2026Full text read0.80
Rethinking dog stress behaviours: contextual and physiological insights from the attachment framework.
FindingOxytocin correlated positively with lip-licking in securely attached dogs (p < 0.05), but negatively in anxious ones (p < 0.05)
Animal2026Full text read0.80
Mifepristone Priming with Misoprostol versus Intracervical Foley’s Catheter with Misoprostol for Induction of Labour in Late Second and Third Trimester Intrauterine Fetal Death: A Prospective Comparative Study
FindingMean induction-to-delivery interval was 25.43±6.84 hours in Group A vs 29.26±5.54 hours in Group B; p=0.0014.
Human2026Full text read0.80
Castor oil plus sweeping membrane maneuver versus oral Misoprostol for labor induction: a prospective observational study
Finding59.2% achieved labor onset within 24 hours in the non-pharmacological group vs. 56.1% in the misoprostol group.
Human2026Full text read0.80
Behavioral effects of interactions between oxytocin and sex hormone-related proxies: a systematic review
FindingNot reported in abstract.
review2026Full text read0.80
Oxytocin reshapes fear control: intensity-dependent prefrontal dominance and whole-brain integration during naturalistic viewing
FindingNot reported in abstract.
Human2026Full text read0.80
Oxytocin receptor Gαi signaling drives valence reassignment to facilitate reversal of social trauma-induced avoidance
FindingNot reported in abstract.
Animal2026Full text read0.70
PHOTORELEASE OF OXYTOCIN IN VIVO USING PHOTOSWITCHABLE NANOVESICLES MODULATES HIPPOCAMPAL CIRCUIT DYNAMICS AND SOCIAL BEHAVIOR
FindingNear-complete release achievable within a ~2-hour window.
Animal2026Full text read0.70

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Oxytocin will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Oxytocin is discussed should be drawn from it.

Articles mentioning Oxytocin