Peptides DB

Research-centric peptide and protocol reference hub

Best Peptides for Cognitive & Nootropic

Semax, Selank, Cerebrolysin, Dihexa, P21, NA-Semax Amidate, and Cyclic Glycine-Proline are the most-studied peptides for cognitive function — memory consolidation, focus, neuroprotection, synaptic plasticity, and recovery from neurological insult. Each entry below links to its full research profile.

Ranked by approved-study count. 8 peptides in this category.

OxytocinFDA Approved

Neurohypophysial Peptide | Social Bonding & Reproductive Hormone

### Oxytocin Summary Oxytocin is a neuropeptide that plays a crucial role in social bonding, reproductive behaviors, and emotional regulation. Its functions extend to various physiological processes, including childbirth and lactation, and it has garnered interest for its potential therapeutic applications in mental health and social disorders.

4 studiesDominant effect: neuro
SelankWell Studied

Anxiolytic & Nootropic Peptide | Tuftsin Analog

### Selank Summary Selank is a synthetic peptide derived from the naturally occurring peptide tuftsin, primarily studied for its potential anxiolytic and cognitive-enhancing properties. Research into Selank has focused on its effects on neuroprotection, stress response, and cognitive function, although further studies are needed to fully understand its mechanisms and therapeutic applications.

4 studiesDominant effect: neuro
SemaxWell Studied

Synthetic ACTH Analog | Nootropic & Neuroprotective Peptide

### Summary Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH) that has been investigated for its potential neuroprotective and cognitive-enhancing effects. Research suggests that Semax may influence various biological pathways, including neuroinflammation and intracellular calcium dynamics.

4 studiesDominant effect: neuro
DSIPEmerging

Delta Sleep-Inducing Peptide | Sleep & Stress Modulator

Delta Sleep-Inducing Peptide, primarily discussed for sleep quality, stress modulation, and pain.

4 studiesDominant effect: sleep
ARA 290Extensively Studied

Tissue-Protective Peptide | Innate Repair Receptor Agonist

ARA 290

4 studiesDominant effect: aesthetic
DihexaEmerging

Synaptogenic Peptide | Cognitive Enhancement

Experimental nootropic peptide investigated for neuroprotection, memory, and stroke/spinal-cord recovery.

4 studiesDominant effect: healing
HumaninModerate Research

Mitochondria-Derived Peptide | HN

Mitochondria-associated peptide explored for longevity, metabolic, and organ-protective effects.

4 studiesDominant effect: metabolic
PE 22-28Emerging

TREK-1 Channel Blocker | Shortened Spadin Analog

### Summary PE 22-28 is a peptide that has garnered attention in various research contexts, particularly in relation to vascular health and metabolic conditions. Its potential implications in gestational diabetes and placental function are areas of ongoing investigation.

4 studies