Best Peptides for Longevity
Epitalon, NAD+, Glutathione, SS-31 (Elamipretide), FOXO4-DRI, MOTS-c, and Humanin are the peptides most-studied for longevity-related endpoints — telomere maintenance, mitochondrial function, senescence clearance, and metabolic age markers. Each entry below links to its full research profile.
Ranked by approved-study count. 10 peptides in this category.
Body Protection Compound-157 | Pentadecapeptide
Body Protective Compound often discussed for soft-tissue repair, GI support, and inflammation modulation.
Synthetic Thymic Hormone | Immune System Modulator
### Thymosin Alpha-1 Summary Thymosin Alpha-1 (Tα1) is a peptide that plays a crucial role in modulating immune responses and has been investigated for its potential therapeutic applications in various conditions, including infections and inflammatory diseases.
Anxiolytic & Nootropic Peptide | Tuftsin Analog
### Selank Summary Selank is a synthetic peptide derived from the naturally occurring peptide tuftsin, primarily studied for its potential anxiolytic and cognitive-enhancing properties. Research into Selank has focused on its effects on neuroprotection, stress response, and cognitive function, although further studies are needed to fully understand its mechanisms and therapeutic applications.
Synthetic ACTH Analog | Nootropic & Neuroprotective Peptide
### Summary Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH) that has been investigated for its potential neuroprotective and cognitive-enhancing effects. Research suggests that Semax may influence various biological pathways, including neuroinflammation and intracellular calcium dynamics.
Synaptogenic Peptide | Cognitive Enhancement
Experimental nootropic peptide investigated for neuroprotection, memory, and stroke/spinal-cord recovery.
Mitochondria-Derived Peptide | HN
Mitochondria-associated peptide explored for longevity, metabolic, and organ-protective effects.
TREK-1 Channel Blocker | Shortened Spadin Analog
### Summary PE 22-28 is a peptide that has garnered attention in various research contexts, particularly in relation to vascular health and metabolic conditions. Its potential implications in gestational diabetes and placental function are areas of ongoing investigation.
Mitochondrial-Targeted Peptide | Cardiolipin Protector
### Summary SS-31, also known as Elamipretide, is a peptide that has garnered attention for its potential role in mitochondrial protection and its implications in various health conditions, particularly those involving oxidative stress and mitochondrial dysfunction.
Mitochondrial-Derived Peptide | Metabolic Regulator
### Summary MOTS-C is a mitochondrial-derived peptide that has garnered attention for its potential roles in metabolic regulation and cellular stress responses. Emerging research suggests it may have implications in various health conditions, including cardiovascular diseases and placental function.
NNMT Inhibitor | Longevity & Metabolic Enhancement
Research-peptide often discussed for body recomposition: weight-loss–focused with muscle preservation, cholesterol and inflammation effects.