Best peptides for Longevity
Epitalon, NAD+, Glutathione, SS-31 (Elamipretide), FOXO4-DRI, MOTS-c, and Humanin are the peptides most-studied for longevity-related endpoints — telomere maintenance, mitochondrial function, senescence clearance, and metabolic age markers. Each entry below links to its full research profile.
Mitochondrial function | Longevity
Humanin is a mitochondria-derived peptide that has garnered attention for its potential roles in cellular health and longevity. It is encoded by the mitochondrial genome and is involved in various cellular processes, including the regulation of apoptosis, inflammation, and oxidative stress. The peptide has been implicated in protective mechanisms against neurodegenerative diseases and metabolic disorders, suggesting its potential as a therapeutic agent in these conditions.
Telomerase stimulation | Aging support
Epitalon, also known as Epithalon or Epithalamin, is a synthetic tetrapeptide derived from the pineal gland that has garnered interest for its potential effects on aging and various physiological processes. Research has explored its bioactive properties, particularly in relation to reproductive health and the aging of the pineal gland.
Disrupts FOXO4-p53 | Senescent cell clearance
FOXO4-DRI (FOXO4-D-Retro-Inverso) is a synthetic peptide designed as a senolytic agent, targeting the interaction between FOXO4 and p53 to induce selective apoptosis in senescent cells. The mechanism of action involves disrupting the FOXO4-p53 complex, which is crucial for maintaining cellular senescence. By inhibiting this interaction, FOXO4-DRI promotes the death of senescent cells, potentially alleviating age-related pathologies and improving tissue function.
N-Acetyl Selank Amidate | Enhanced Tuftsin Analog
Adalank (N-Acetyl Selank Amidate) is a modified analog of the Russian heptapeptide Selank, designed for enhanced metabolic stability and investigated for anxiolytic and nootropic effects.
EDG Tripeptide | Bronchial/Lung Bioregulator
Chonluten is a short Glu-Asp-Gly (EDG) peptide bioregulator researched by the Khavinson group as a tissue-specific modulator of bronchial and lung epithelium.
EDP Tripeptide | Thymus Immune Bioregulator
Crystagen (EDP) is a synthetic tripeptide bioregulator from the Khavinson family, researched as a thymus-targeted immune modulator and investigational geroprotective agent.
Related reading
Peptides studied for energy, mitochondrial function, and exercise capacity — NAD+, MOTS-c, AICAR, SS-31, SLU-PP-332 — with what each does and what's realistic.
The defensible sleep-focused peptide stack — DSIP for slow-wave-sleep induction plus a GH secretagogue layer for amplified nocturnal GH pulse — with realistic expectations and what not to add.
Most 'anti-aging peptide stacks' over-promise. Here's a defensible combination — NAD+, GHK-Cu, Epitalon, SS-31 — with what each does, what the evidence supports, and what's speculative.
Dosing for approved agents comes from the label, not from this site. If you are working out injection volumes, the reconstitution calculator converts mg per vial into syringe units, and how to use peptides covers storage and handling. Neither is a recommendation to use anything.
Rankings reflect how much indexed research exists, not how safe or effective anything is for you. Nothing here is medical advice. Most peptides on this site are not approved drugs.