Best peptides for Longevity
Epitalon, NAD+, Glutathione, SS-31 (Elamipretide), FOXO4-DRI, MOTS-c, and Humanin are the peptides most-studied for longevity-related endpoints — telomere maintenance, mitochondrial function, senescence clearance, and metabolic age markers. Each entry below links to its full research profile.
Mitochondrial function | Longevity
Humanin is a mitochondria-derived peptide that plays a significant role in cellular health and longevity. It is encoded by the mitochondrial genome and has been implicated in various cellular processes, including the regulation of apoptosis, inflammation, and oxidative stress. Humanin has been shown to exert protective effects in models of neurodegenerative diseases and metabolic disorders, suggesting its potential as a therapeutic agent in these conditions.
Telomerase activation | Longevity
Epitalon, also known as Epithalon or Epithalamin, is a synthetic tetrapeptide derived from the pineal gland that has garnered interest for its potential effects on aging and various physiological processes. Research has explored its bioactive properties, particularly in relation to reproductive health and the aging of the pineal gland.
Synthetic ACTH Analog | Nootropic & Neuroprotective Peptide
Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH) that has been investigated for its potential neuroprotective and cognitive-enhancing effects. Research suggests that Semax may influence various biological pathways, including neuroinflammation and intracellular calcium dynamics.
AEDR | Cardiovascular Bioregulator Peptide
Cardiogen (AEDR) is a short synthetic peptide bioregulator researched primarily for cardiovascular tissue support, vascular function, and age-related cardiac decline in preclinical models.
Bioregulatory Tripeptide | Cartilage & Connective Tissue Support
Cartalax (AED) is a synthetic Khavinson tripeptide researched as a cartilage and connective tissue bioregulator, with most evidence drawn from Russian preclinical and gerontology work.
Senolytic Peptide | p53-FOXO4 Disruptor
FOXO4-DRI is a synthetic D-retro-inverso senolytic peptide designed to disrupt the FOXO4-p53 interaction and trigger selective apoptosis in senescent cells in preclinical longevity research.
Related reading
Peptides studied for energy, mitochondrial function, and exercise capacity — NAD+, MOTS-c, AICAR, SS-31, SLU-PP-332 — with what each does and what's realistic.
The defensible sleep-focused peptide stack — DSIP for slow-wave-sleep induction plus a GH secretagogue layer for amplified nocturnal GH pulse — with realistic expectations and what not to add.
Most 'anti-aging peptide stacks' over-promise. Here's a defensible combination — NAD+, GHK-Cu, Epitalon, SS-31 — with what each does, what the evidence supports, and what's speculative.
Dosing for approved agents comes from the label, not from this site. If you are working out injection volumes, the reconstitution calculator converts mg per vial into syringe units, and how to use peptides covers storage and handling. Neither is a recommendation to use anything.
Rankings reflect how much indexed research exists, not how safe or effective anything is for you. Nothing here is medical advice. Most peptides on this site are not approved drugs.