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Epitalon (Epithalon) record · updated 20h ago

Sleep & circadianNeuro & moodGrade B · human evidenceResearch use only
All 14 studiesJump to the evidenceCompare
What is Epitalon (Epithalon) used for?

Epitalon, also known as Epithalon or Epithalamin, is a synthetic tetrapeptide derived from the pineal gland that has garnered interest for its potential effects on aging and various physiological processes. Research has explored its bioactive properties, particularly in relation to reproductive health and the aging of the pineal gland.

How it works: Tetrapeptide (Ala-Glu-Asp-Gly); pineal / telomerase signaling

Primarily researched for · Sleep & circadianRoute · Subcutaneous injection (research use)

Development stage

where Epitalon (Epithalon) sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 62 registered trials. It describes the research record, not a recommendation.

Identity
NameEpitalon (Epithalon)
Chain length4 amino acids
SequenceAEDG
Molecular weight390.4 Da
FormulaC14H22N4O9
Structure typePeptide
ClassLongevity
Research levelWell Studied
Discovered byCurated master list · 2025

Mass and formula from PubChem CID 219042. The chain length is only shown where the residues account for that mass, so a figure here has been checked against it rather than taken on trust.

Pharmacology
MechanismTetrapeptide (Ala-Glu-Asp-Gly); pineal / telomerase signaling
RouteSubcutaneous injection (research use)
Half-life—
Time to peak—
Duration—
Extraction confidence0.45
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Aug 24, 2026. How this works →
Research stats
Total studies14
Human / animal / cellular5 / 3 / 1
Highest trial phasePreclinical
Years covered2008–2026
Latest study2d ago
Publication history
20082026
Research funding
—no NIH grants found
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

14 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Depression and risk of incident heart diseases among older adults at CKM stages 0-3: evidence from the China Health and Retirement Longitudinal Study.
FindingOR 1.62, 95%CI:1.34-2.03 for IHD after multivariable adjustment.
Human2026Full text read0.80
Role of apparent diffusion coefficient (ADC) and MRI-derived parameters in identifying p53-abnormal subtypes of endometrial cancer.
FindingBest cutoff point of ADC for discrimination was 695, yielding a sensitivity of 100% and specificity of 83%.
Human2026Full text read0.80
Integrating in vitro aerosol characterization and cross-species PBPK modeling to predict human lung exposure of inhaled therapeutic proteins.
Finding85% of Cmax and AUC0-inf values fell within a 0.5-2.0-fold error range.
review2026Full text read0.70
Terpene synthases screening in agarwood tree <i>Aquilaria yunnanensis</i> leads to the discovery of agarospirol.
FindingNot reported in abstract.
In vitro2026Full text read0.70
Tubular dysfunction in stable adult sickle cell patients in Kinshasa: prevalence and associated factors - a cross-sectional study.
Finding20.8% of patients had tubulopathy.
Human2026Full text read0.90
Association between serum iodine and thyroid function in Malagasy adults: a cross-sectional study in a tertiary-level hospital in Antananarivo, Madagascar.
FindingOR=108 [17-680] for the association between HLSI and dysthyroidism.
Human2023Full text read0.80
Optimizing childhood vaccination coverage in Lubumbashi: Expert perspectives on the SCAVA / VACCIN+CONNECT- OS initiative.
Finding80% (90/111) supported the initiation of the SCAVA / VACCIN+CONNECT- OS study.
review2026Full text read0.70
Nephrotoxic medication burden and drug-related problems in patients with chronic kidney disease using SGLT2 inhibitors.
FindingMedian number of nephrotoxic drugs per patient was 2 (IQR: 1-3).
Human2023Full text read0.80
Exosomes delivering a high-throughput-screened RNA polymerase inhibitor for highly effective therapy of multidrug-resistant bacterial infected pneumonia.
Finding99% eradication of S. aureus and MDR E. coli within 12 h.
Animal2026Full text read0.70
[Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats].
FindingNot reported in abstract.
Animal2008Full text read0.70
Semantic Scholar search for Epitalon (Epithalon, Epithalamin)
TakeawayNot reported in abstract.
—2010Title only0.00
[Morphofunctional and molecular bases of pineal gland aging].
TakeawayThe review highlights the potential of epithalon and epithalamin to influence melatonin secretion in the aging pineal gland, but lacks detailed evidence to support strong conclusions.
review2012Title only0.30

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Epitalon (Epithalon) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Epitalon (Epithalon) is discussed should be drawn from it.

Articles mentioning Epitalon (Epithalon)