Best peptides for Energy & Performance
NAD+, MOTS-c, AICAR (Acadesine), L-Carnitine, SLU-PP-332 (Exercise Mimetic), and SS-31 are the peptides most-studied for energy production, mitochondrial function, exercise capacity, and athletic performance. Each entry below links to its full research profile.
Essential Cellular Coenzyme & Anti-Aging Therapy
### Summary NAD+ (Nicotinamide adenine dinucleotide) is a crucial coenzyme involved in various metabolic processes, including energy production and cellular repair mechanisms. Recent research highlights its potential roles in protecting against oxidative stress and enhancing therapeutic efficacy in certain cancer treatments.
Mitochondrial-Targeted Peptide | Cardiolipin Protector
### Summary SS-31, also known as Elamipretide, is a peptide that has garnered attention for its potential role in mitochondrial protection and its implications in various health conditions, particularly those involving oxidative stress and mitochondrial dysfunction.
Mitochondrial-Derived Peptide | Metabolic Regulator
### Summary MOTS-C is a mitochondrial-derived peptide that has garnered attention for its potential roles in metabolic regulation and cellular stress responses. Emerging research suggests it may have implications in various health conditions, including cardiovascular diseases and placental function.
Amino Acid Derivative | Fatty Acid Transporter
L-Carnitine (levocarnitine) is an amino acid derivative that shuttles long-chain fatty acids into mitochondria for energy production, studied for metabolic, cardiovascular, and exercise performance applications.
5-Aminoimidazole-4-carboxamide Ribonucleotide | AMPK Activator
AICAR (Acadesine) is a small-molecule AMPK activator studied for metabolic, endurance, and cardioprotective effects. It mimics AMP to shift cells toward energy-producing pathways.
Related reading
Peptides studied for energy, mitochondrial function, and exercise capacity — NAD+, MOTS-c, AICAR, SS-31, SLU-PP-332 — with what each does and what's realistic.
SLU-PP-332 is a synthetic pan-ERR agonist that mimics endurance-exercise gene expression in animal models. Here's what's actually known, what's speculative, and why caution is warranted.
Dosing for approved agents comes from the label, not from this site. If you are working out injection volumes, the reconstitution calculator converts mg per vial into syringe units, and how to use peptides covers storage and handling. Neither is a recommendation to use anything.
Rankings reflect how much indexed research exists, not how safe or effective anything is for you. Nothing here is medical advice. Most peptides on this site are not approved drugs.