Best peptides for Energy & Performance
NAD+, MOTS-c, AICAR (Acadesine), L-Carnitine, SLU-PP-332 (Exercise Mimetic), and SS-31 are the peptides most-studied for energy production, mitochondrial function, exercise capacity, and athletic performance. Each entry below links to its full research profile.
Mitochondrial protection | Heart and neuro health
SS-31, also known as Elamipretide, is a peptide that has garnered attention for its potential role in mitochondrial protection and its implications in various health conditions, particularly those involving oxidative stress and mitochondrial dysfunction.
Metabolic | Energy production and cellular repair
NAD+ (Nicotinamide adenine dinucleotide) is a crucial coenzyme involved in various metabolic processes, including energy production and cellular repair mechanisms. Recent research highlights its potential roles in protecting against oxidative stress and enhancing therapeutic efficacy in certain cancer treatments.
ERR Agonist | Metabolic Modulator
Synthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator
Metabolic regulation | Male fertility
MOTS-C is a mitochondrial-derived peptide that has garnered attention for its potential roles in metabolic regulation and cellular stress responses. Emerging research suggests it may have implications in various health conditions, including cardiovascular diseases and placental function.
Fatty acid transport | Metabolic health
L-Carnitine (levocarnitine) is an amino acid derivative that shuttles long-chain fatty acids into mitochondria for energy production, studied for metabolic, cardiovascular, and exercise performance applications.
AMPK activator | Metabolic efficiency
AICAR (Acadesine) is a small-molecule compound that acts as an activator of AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. By mimicking AMP, AICAR promotes a shift in cellular metabolism towards energy-producing pathways, thus enhancing metabolic efficiency. The activation of AMPK by AICAR has been linked to various physiological effects, including improved endurance, metabolic adaptation, and cardioprotective properties.
Related reading
Peptides studied for energy, mitochondrial function, and exercise capacity — NAD+, MOTS-c, AICAR, SS-31, SLU-PP-332 — with what each does and what's realistic.
SLU-PP-332 is a synthetic pan-ERR agonist that mimics endurance-exercise gene expression in animal models. Here's what's actually known, what's speculative, and why caution is warranted.
Dosing for approved agents comes from the label, not from this site. If you are working out injection volumes, the reconstitution calculator converts mg per vial into syringe units, and how to use peptides covers storage and handling. Neither is a recommendation to use anything.
Rankings reflect how much indexed research exists, not how safe or effective anything is for you. Nothing here is medical advice. Most peptides on this site are not approved drugs.