Research library

D

grade

Menopausal status and elevated FSH levels show more consistent associations with Alzheimer's biomarkers than hormone therapy. However, the evidence is mixed and further longitudinal studies are needed.

Not reported in abstract.

summary

B

grade

The long acting GnRH-a protocol showed a higher clinical pregnancy rate of 33.12% compared to 28.23% for the short acting protocol, indicating a potential preference for the long acting approach in IVF/ICSI cycles.

Clinical pregnancy rates: LAP 33.12% vs SAP 28.23%, p=0.001.

summary

B

grade

The study found that using recombinant LH in IVF cycles resulted in a higher mean number of mature and fertilized oocytes compared to using highly purified hMG, but no differences in pregnancy rates were observed.

Mean number of mature oocytes retrieved: 10 ± 5.8 in rFSH+rLH vs 8.3 ± 4.6 in HP-hMG, p=0.01.

summary

B

grade

Letrozole may improve implantation rates in women with PCOS undergoing IVF, but no significant differences were found in other key reproductive outcomes.

42.22% implantation rate in letrozole group vs. 34.69% in control group, p<0.05

summary

B

grade

AMH levels may help classify ovarian response in ART, but the clinical implications of adjusting stimulation protocols based on these levels require further investigation.

Not reported in abstract.

summary

B

grade

In women undergoing elective fertility preservation, rFSH appears to yield more oocytes than hp-hMG, but the implications of these findings should be interpreted with caution due to potential confounding factors.

Peak estradiol level was significantly lower in the rFSH group (2547.18±1648.21 pg/mL) than in the hp-hMG group (3468.02±2497.69 pg/mL, P<0.001).

summary

B

grade

Normal FSH levels in suspected ovarian hyperstimulation syndrome may indicate an FSH-secreting tumor, highlighting the need for careful hormonal assessment.

Estradiol elevated at 737 pg/ml.

summary

C

grade

EZTG appears to improve ovarian function and antioxidant defenses in aged mice, but its relevance to human health is unclear.

Not reported in abstract.

summary

B

grade

Recombinant LH supplementation may be associated with a higher cumulative live birth rate compared to rFSH alone in women of advanced reproductive age undergoing ART, but results should be interpreted with caution due to study limitations.

Adjusted sHR for rFSH+rLH vs rFSH was 1.29, 95% CI 1.04-1.61, P=0.020.

summary

A

grade

Live birth rates may be lower and the risk of ovarian hyperstimulation syndrome may be higher with rFSH compared to HMG/HP-HMG in assisted reproductive technology cycles.

Live birth is probably lower with rFSH compared to HMG/HP-HMG (OR 0.83, 95% CI 0.73 to 0.95; 15 studies, 4793 participants, moderate-certainty evidence).

summary

B

grade

PVS abnormalities are associated with poorer embryo quality in ICSI cycles, but the clinical implications for pregnancy outcomes remain unclear.

Fertilization rates: normal PVS oocytes 147/172 (85.4%), PVS-L oocytes 132/177 (74.5%), p=0.082.

summary

C

grade

Primed AMSC-sEVs appear to restore granulosa cell function more effectively than hMG alone in a CTX-induced dysfunction model, but the implications for clinical practice are unclear.

Not reported in abstract.

summary

B

grade

This case report illustrates that individualized gonadotropin therapy may restore ovulation and lead to successful pregnancy in women with isolated hypogonadotropic hypogonadism and partial empty sella syndrome.

Pregnancy achieved after one stimulation cycle with human menopausal gonadotropin.

summary

B

grade

The minimal stimulation protocol resulted in a higher live birth rate of 58.20% compared to 51.20% for the antagonist protocol, suggesting it may be beneficial for some patients.

58.20% live birth rate in minimal stimulation group vs 51.20% in antagonist group, p=0.035.

summary

B

grade

HyperSperm treatment resulted in a higher blastocyst development rate (55.6%) compared to standard preparation (47.9%), suggesting potential benefits for embryo development in IVF.

55.6% blastocyst development rate with HyperSperm vs 47.9% with standard preparation, p=0.0038.

summary

A

grade

The HP-HMG pen formulation demonstrated non-inferiority to the powder formulation in terms of fertilized oocytes, but the clinical significance of the differences observed should be interpreted with caution.

Mean number of fertilized 2PN oocytes: 8.2 ± 5.5 (pen) vs 6.6 ± 4.3 (powder), adjusted treatment difference: 1.50, 95% CI 0.57 to 2.42.

summary

B

grade

Simultaneous trophectoderm biopsies may enable preimplantation genetic testing in challenging cases of de novo incontinentia pigmenti, but further research is needed to confirm these findings.

10 euploid embryos tested negative for the IKBKG deletion.

summary

A

grade

Live birth and clinical pregnancy rates are probably lower with rFSH compared to HMG/HP-HMG, while the risk of ovarian hyperstimulation syndrome is probably higher with rFSH.

Live birth is probably lower with rFSH compared to HMG/HP-HMG (OR 0.83, 95% CI 0.73 to 0.95; 15 studies, 4793 participants, moderate-certainty evidence).

summary