Comparison between the efficacy of short and long GnRH-a protocols as a clinical outcome for viable pregnancies in women undergoing IVF/ICSI Cycles.
The long acting GnRH-a protocol showed a higher clinical pregnancy rate of 33.12% compared to 28.23% for the short acting protocol, indicating a potential preference for the long acting approach in IVF/ICSI cycles.
Where it sits
this study against the rest of the hmg (human menopausal gonadotropin) corpusSummary and findings
This study compared the efficacy of short and long acting GnRH-a protocols on pregnancy outcomes in women undergoing IVF/ICSI cycles. A total of 540 cycles were analyzed, with the long acting protocol showing higher clinical pregnancy rates and other metrics compared to the short acting protocol. No therapeutic claims are made.
Abstract
This retrospective case control study was executed to compare the efficacy of short and long acting Gonadotropin releasing hormone agonist (GnRH-a) on pregnancy outcome. A total of 540 cycles with a history of male factor were identified from 2013 to 2016. The patients were separated into two groups: long acting protocol (LAP) group consisting of 310 cycles which were induced by a combination of GnRH-a incorporated with Follicular stimulating hormone (FSH) and Human menopausal gonadotropin (hMG), while short acting protocol (SAP) group or flare up regimen comprises of 230 cycles introduced by a combination of GnRH-a along with FSH and hMG. Patients are divided into subsequent age groups ≤ 30, 31–35, 36–40 and > 40 years. In comparison with the SAP group, the duration of ovarian stimulation, calculated dose of GnRH-a, number of retrieved mature oocytes, good quality embryos for implantation and persistent pregnancies were all significantly found to be high ( p < 0.05) in the LAP group as compared to the SAP group. The clinical pregnancy rates were comparatively high in the LAP group (33.12%; P = 0.001) than in the SAP group (28.23%). The findings of our study revealed that irrespective of patient’s age, the long acting protocol was more reliable and fertile with reference to number of mature oocytes retrieved, time period for stimulation, total dose of GnRH-a during controlled ovarian hyperstimulation, high quality embryos, fertilization and cleavage rate as well as pregnancy outcome.