Pre-vaccination immune signatures of children with inborn errors of immunity associate with COVID-19 vaccine response.
Distinct pre-vaccination immune signatures may help predict how well children with inborn errors of immunity respond to COVID-19 vaccines, indicating a need for personalized vaccination approaches.
Where it sits
this study against the rest of the pnc-27 corpusSummary and findings
This study measured baseline immune transcriptional signatures in 21 SARS-CoV-2-naïve children with inborn errors of immunity to predict humoral responses to the BNT162b2 mRNA vaccine. Participants were stratified into high or low responders based on anti-SARS-CoV-2 spike IgG titers at day 28 post-vaccination. The study found significant differences in immune cell activation and gene expression between the two groups.
Abstract
Individuals with inborn errors of immunity often mount suboptimal responses to vaccination, yet the molecular determinants underlying their variable responses to mRNA vaccines remain poorly defined. The present study aimed to identify baseline immune transcriptional signatures predictive of humoral responses to the BNT162b2 (Comirnaty) mRNA vaccine in individuals with inborn errors of immunity. Twenty-one SARS-CoV-2-naïve participants with diverse inborn errors of immunity were stratified as high or low responders to the BNT162b2 vaccine based on anti-SARS-CoV-2 spike IgG titers at day 28 post-vaccination. Although vaccine-induced T cell responses were broadly comparable, low responders had significantly lower frequencies of switched memory B cells (<i>p</i> = .014). Transcriptional profiling revealed 41 differentially expressed genes between groups at baseline. Activated memory B cells and peripheral T follicular helper cells from high responders exhibited greater induction of activation and memory-related genes, including NFKB1, CD69, TIGIT, CD40L, and BATF, indicating greater intrinsic readiness to support coordinated antibody production. These findings demonstrate that distinct pre-vaccination gene expression patterns within specific immune subsets are associated with differential humoral responses to mRNA vaccination in individuals with inborn errors of immunity. More broadly, the study highlights that baseline molecular immune features substantially influence vaccine efficacy and suggests that pre-vaccination transcriptional profiling may enable more personalized vaccination strategies for individuals with impaired immunity.
Background
This paper addresses the relationship between immune signatures and vaccine response in children with inborn errors of immunity, a population that may have altered immune responses. Previous studies have indicated that individuals with immune deficiencies may respond differently to vaccinations. Understanding these differences is crucial for tailoring vaccination strategies in vulnerable populations.
Methods
Not reported in abstract.
Results
Not reported in abstract.
Interpretation
Not reported in abstract.
Key findings
- Not reported in abstract.
Limitations
- Not reported in abstract.