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PNC-27 record · updated 18h ago

Healing & recoveryInflammation & immuneGrade A · human clinicalResearch use only
All 20 studiesJump to the evidenceCompare
What is PNC-27 used for?

PNC-27 is a peptide designed to disrupt the interaction between the tumor suppressor protein p53 and its negative regulator, HDM2 (human double minute 2). This interaction is crucial in the regulation of cell cycle and apoptosis, as p53 is a key player in preventing cancer cell proliferation. By inhibiting the p53-HDM2 interaction, PNC-27 aims to restore the function of p53, thereby promoting apoptosis in cancer cells and potentially reducing tumor growth.

How it works: p53-hDM2 disruptor

Primarily researched for · Healing & recovery

Development stage

where PNC-27 sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 7 registered trials. It describes the research record, not a recommendation.

Identity
NamePNC-27
Chain length—
Molecular weight4,032 Da
FormulaC188H293N53O44S
Structure typeNot established
ClassHealing
Research levelPreclinical
Discovered byCurated master list · 2026

Mass and formula from PubChem CID 16201774. No verified residue count for this compound.

Pharmacology
Mechanismp53-hDM2 disruptor
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence0.70
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Sep 6, 2026. How this works →
Research stats
Total studies20
Human / animal / cellular13 / 1 / 1
Highest trial phasePreclinical
Years covered2025–2026
Latest study1mo ago
Publication history
20252026
Research funding
18,358 NIH projects · $25.9M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

20 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Heterostructured Materials for Room-Temperature Na-S Batteries: Directional Design Strategies and Multifaceted Applications.
TakeawayHeterostructure engineering offers a promising approach to improve room-temperature sodium-sulfur battery performance, but empirical validation is needed.
review2026Full text read0.80
Inequalities in maternal health service utilisation in Somalia: analysis of the 2020 Somali health and demographic survey.
Finding32.4% attended at least one ANC visit.
Human2026Full text read0.90
Spatial lipidomics of the human brain: systematic review of current state and future perspectives.
FindingNot reported in abstract.
review2026Full text read0.80
Systematic Review and Meta-Analysis: Do Youth-Reported Psychosis Symptoms Predict Later Mental Health Diagnosis?
FindingOR = 3.11, CI = 2.11 - 4.58, p < 0.0090 for psychotic disorder diagnosis.
review2026Full text read0.80
Associations between corticolimbic glutamatergic metabolites and functional connectivity in people at clinical high-risk for psychosis
Findingp-FDR=0.021 for interaction between group and ACC Glx for FC between the NAc and the bilateral amygdala and hippocampus.
Human2026Full text read0.80
Social and spatial disparities in heat-related mortality in Italy: a nationwide small-area study
Finding17,828 deaths (95% credible intervals: 17,339, 18,285) among older adults in 2022.
review2026Full text read0.80
Are CNV Risk Scores Linked to Neurodevelopmental and Mental Health Characteristics Within CNV-Associated Intellectual Disability?
FindingHigher summed pLI scores predicted fewer MH difficulties, n=1640.
Human2026Full text read0.80
Effects of Maternal Utilization of Continuum of Care from Pregnancy to Postpartum on Breastfeeding Practices in Bangladesh.
FindingReceiving a PNC within 48 hours of delivery was significantly associated with 70% higher odds of exclusive breastfeeding in BDHS 2022 sample, AOR: 1.70, 95% CI [1.21, 2.39].
Human2026Full text read0.80
Experimental human pneumococcal carriage in adults with HIV in Malawi
FindingAdjusted odds ratio for carriage acquisition in PLHIV was 0·39 (95% CI 0·16-0·91).
Human2026Full text read0.80
The Hidden Architecture of Brain Structural Variability in 22q11.2 Deletion Syndrome: A Multi-site Study
FindingNot reported in abstract.
Human2026Full text read0.80
Gut microbiome and plasma metabolic signatures of one-carbon metabolism differentiate oedematous and non-oedematous severe acute malnutrition
FindingNot reported in abstract.
Human2025Full text read0.80
Dissecting heterogeneous brain development and aging using voxelwise normative models
FindingNot reported in abstract.
Human2026Full text read0.70

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching PNC-27 will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much PNC-27 is discussed should be drawn from it.