Research library

D

grade

Youth reporting psychosis spectrum symptoms are at a significantly increased risk of later mental health diagnoses, particularly psychotic disorders, but the clinical implications require careful consideration.

OR = 3.11, CI = 2.11 - 4.58, p < 0.0090 for psychotic disorder diagnosis.

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B

grade

Increased risk for psychosis is linked to altered relationships between corticolimbic connectivity and glutamatergic function, but the clinical implications remain uncertain due to the small sample size.

p-FDR=0.021 for interaction between group and ACC Glx for FC between the NAc and the bilateral amygdala and hippocampus.

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D

grade

Heat-related mortality in Italy shows significant geographical disparities, with socio-economic factors playing a crucial role in vulnerability among older adults.

17,828 deaths (95% credible intervals: 17,339, 18,285) among older adults in 2022.

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B

grade

Higher CNV risk scores may predict fewer mental health difficulties in children with intellectual disability, but this relationship is complex and varies by score range.

Higher summed pLI scores predicted fewer MH difficulties, n=1640.

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B

grade

Receiving postnatal care within 48 hours is associated with higher odds of exclusive breastfeeding, but the overall effects of maternal health services on breastfeeding practices are inconsistent.

Receiving a PNC within 48 hours of delivery was significantly associated with 70% higher odds of exclusive breastfeeding in BDHS 2022 sample, AOR: 1.70, 95% CI [1.21, 2.39].

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B

grade

In this study, 21% of PLHIV acquired experimental pneumococcal carriage, which is lower than the 36% in HIV-uninfected controls, suggesting that prolonged carriage duration may be a key factor in high carriage rates among PLHIV.

Adjusted odds ratio for carriage acquisition in PLHIV was 0·39 (95% CI 0·16-0·91).

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B

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This study found that 22q11DS is associated with increased regional heterogeneity in cortical thickness and lower heterogeneity in surface area, suggesting individualized neurobiological processes.

Not reported in abstract.

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B

grade

Children with oedematous severe acute malnutrition show distinct gut microbiome and metabolic profiles compared to those with non-oedematous forms, which persist for up to 48 weeks post-discharge.

Not reported in abstract.

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B

grade

Voxelwise normative modeling can highlight individualized brain alterations and deviations in brain morphology, but specific statistical measures are needed to understand their clinical significance.

Not reported in abstract.

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B

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This study suggests a potential link between brain connectivity patterns and symptoms of neurodevelopmental psychopathology, indicating a continuum between neurotypical and neurodivergent profiles.

Not reported in abstract.

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C

grade

PNC-27 shows cytotoxic effects on cervical cancer cells at an IC50 of 12.4 μM while sparing normal cervical cells, likely due to the unique expression of HDM-2 in cancer cells.

IC50=12.4 μM for HTB-35 cervical cancer cells.

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B

grade

Endodontic treatment in patients with apical periodontitis is associated with decreased inflammatory markers and improved endothelial barrier integrity, but the clinical implications need further investigation.

Serum ZO-1 and Claudin-5 levels were significantly higher in AP patients compared to controls at baseline (p<0.001).

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D

grade

Nucleation is a major source of particle number concentrations in urban areas, contributing over 90% in many cases, with transportation and industry also playing significant roles.

NMB for Beijing in April = -0.12

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B

grade

A PNI value of ≥46.2 is associated with improved 5-year survival in postoperative NSCLC patients, indicating a potential link between nutritional status and cancer outcomes.

PNI value of ≥46.2 stratified postoperative NSCLC patients with improved 5-y survival (HR = 0.3889, 95% CI 0.2840-0.5356, p<0.001).

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B

grade

Distinct pre-vaccination immune signatures may help predict how well children with inborn errors of immunity respond to COVID-19 vaccines, indicating a need for personalized vaccination approaches.

Low responders had significantly lower frequencies of switched memory B cells (p = .014).

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C

grade

Both dietary cholesterol and saturated fat are necessary for the development of fibrosing MASH in specific pathogen-free mice, highlighting the role of diet in liver health.

Not reported in abstract.

summary

B

grade

Vaccination against pneumococcal disease is associated with shorter hospital stays and lower costs, but the study highlights ongoing challenges with vaccine coverage against emerging serotypes.

Vaccinated patients reported a median hospital stay of 8 vs 16 d, p<0.001.

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