Muscle NAD(P) metabolism tracks muscle health more than chronological age
NAD(P) metabolism may reflect muscle health more accurately than age, with glutathione levels increasing independently of age-related changes.
Where it sits
this study against the rest of the glutathione (gsh) corpusSummary and findings
This study measured NAD(H), NADP(H), and glutathione levels in muscle biopsies from 137 men aged 20-93 years. It found that NAD(P) pools were not associated with age, while glutathione levels increased without changes in GSH/GSSG ratios. The study suggests that NAD(P) metabolism is more indicative of muscle health than chronological age.
Abstract
Abstract Nicotinamide adenine dinucleotide (NAD⁺) depletion is proposed to drive muscle aging, yet its human relevance remains unresolved. NAD(H), NADP(H) and glutathione were quantified in biopsies from 137 men aged 20-93y. NAD(P) pools were not associated with age, whereas glutathione expanded without altered GSH/GSSG. NAD⁺ and NADPH tracked performance, muscle mass and mitochondrial content beyond age, indicating that NAD(P) metabolism reflects retained muscle health more than aging and arguing against obligatory age-related NAD(P) depletion.
Background
The study likely investigates the relationship between muscle NAD(P) metabolism and muscle health, potentially suggesting that metabolic markers may be more indicative of muscle condition than chronological age. This area of research is important as it could shift focus from age-based assessments to metabolic health indicators in evaluating muscle function.
Methods
Not reported in abstract.
Results
Not reported in abstract.
Interpretation
Without specific data, it is unclear how this study's findings compare to existing literature or whether the effect sizes observed are clinically meaningful. The lack of detailed information limits understanding of the study's implications for practice.
Limitations
- abstract not available
- preprint, not peer-reviewed
- unknown sample size
- unknown study design