Study 17 of 18Gonadorelin (GnRH) literaturebiorxiv-preprint · Observational2021

Effect of Treatment With Gonadoreline at the Embryo Transfer on Pregnancy Outcomes in Bovine.

Gonadorelin treatment may increase conception rates in bovine embryo transfer, particularly in dry and lactating cows, but results should be interpreted cautiously due to potential confounding factors.

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Where it sits

this study against the rest of the gonadorelin (gnrh) corpus

Preclinical

Observational · this one

Open-label

Randomised

Reviews

Summary and findings

This study assessed the effect of gonadorelin on conception rates and pregnancy losses in bovine embryo recipients. A total of 1,311 cows were included, with 624 receiving 0.1 mg gonadorelin on the day of embryo transfer. The treated group showed higher conception rates at 30 and 60 days of gestation compared to controls.

How much of this paper we could read: full text read (0.80). We had a clear abstract, so the summary below closely tracks the paper. What this means →

Conception rate at 30 days: 45.8% in treated group vs control, p=0.03.2021

Abstract

The authors’ words, as biorxiv-preprint supplied them

<title>Abstract</title> <p>The aim of this study was to assess whether administration of the gonadotropin-releasing hormone (GnRH) agonist gonadorelin would increase conception rates at 30 (P / ET 30) and 60 (P / ET 60) days of gestation and reduce pregnancy losses (PL) in embryo recipients and what would be the correlation between the animal category and the season of the year in which the embryo transfer would occur. The experiment was conducted on 11 commercial farms in the state of Minas Gerais, Brazil. Recipients were randomly divided into groups: treated (n = 624), cows that received 0.1 mg gonadorelin on the day of FTET, and control (n = 687), untreated cows. All embryos were produced in vitro from oocyte donors of different races. Recipients were classified as heifers, dry cows or lactating cows. Higher conception rate was observed at 30 days (p = 0.03) and 60 days (p = 0.01) in the treated group (45.8%; 43.0%, respectively). Dry and lactating cows had less pregnancy loss (p = 0.001) compared to heifers (2.70% and 2.47% vs 10.42%, respectively). During spring/summer, there was less P/FTET at 30 days (0.024). Embryo transfer carried out in the warmer seasons of the year reduced the pregnancy rate to 60 days and increased pregnancy loss. As an implication, the use of the GnRH analogue can be used as a tool to increase fertility in embryo recipients.</p>

Elsewhere in the Gonadorelin (GnRH) corpus

CEvaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR <sup>®</sup> protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semenbiorxiv-preprint · 2020 · 82% (629/769) of cows expressed estrus prior to FTAI with 7 & 7 Synch vs 64% (492/769) with 7-day CO-Synch + CIDR, P=0.01.Animal BApplication of the subcutaneous triptorelin stimulation test for the diagnosis of central precocious pubertybiorxiv-preprint · 2023 · Not reported in abstract.Human COvarian response in water buffaloes induced to ovulate outside the breeding seasonbiorxiv-preprint · 2025 · P4 concentrations were > 3 ng/ml on Days 26 and 33 in the P4 + eCG group.Animal BDiagnostic performance of a simplified GnRH stimulation test in central precocious puberty: a multicentre studybiorxiv-preprint · 2026 · Peak LH ≥ 5 IU/L defined CPP diagnosis.Human BIncidence study of precocious puberty in the population of the state of Goiás: did the COVID-19 pandemic modify the epidemiology?PubMed · 2026 · 154% increase in treatment requests during the pandemic, p<0.001.Human BPulmonary alveolar proteinosis diagnosed during leuprorelin acetate therapy for ovarian endometrioma: a case report.PubMed · 2026 · n=1 · White blood cell nadir, 2.94 × 10⁹/L.Human