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Gonadorelin (GnRH) record · updated 7h ago

Healing & recoveryMetabolic & appetiteGrade A · human clinicalResearch use only
All 25 studiesJump to the evidenceCompare
What is Gonadorelin (GnRH) used for?

Gonadorelin is synthetic GnRH, a decapeptide that stimulates pituitary release of LH and FSH in pulsatile fashion — used diagnostically and to support the reproductive hormone axis.

How it works: GnRH receptor agonist

Primarily researched for · Healing & recoveryRoute · Subcutaneous injection

Development stage

where Gonadorelin (GnRH) sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 147 registered trials. It describes the research record, not a recommendation.

Identity
NameGonadorelin (GnRH)
Chain length—
Molecular weight1,182.3 Da
FormulaC55H75N17O13
Structure typeNot established
ClassHealing
Research levelModerate Research
Discovered byCurated master list · 2026

Mass and formula from PubChem CID 638793. No verified residue count for this compound.

Pharmacology
MechanismGnRH receptor agonist
RouteSubcutaneous injection
Half-life~20 min
Time to peak30 min
Duration~2-4 hours
Extraction confidence0.90
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Oct 27, 2026. How this works →
Research stats
Total studies25
Human / animal / cellular9 / 14 / 1
Highest trial phasePreclinical
Years covered2020–2026
Latest study9d ago
Publication history
20202026
Research funding
1,081 NIH projects · $31.0M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

25 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Deoxynivalenol exposure promotes apoptosis and disrupts GnRH-dependent LH production in pituitary gonadotrope-like cells.
FindingNot reported in abstract.
In vitro2026Full text read0.70
Single-dose FSH protocol with 48- or 72-h coasting periods as simplified alternatives for in vitro embryo production in Angus oocyte donor cows.
FindingNot reported in abstract.
Animal2026Full text read0.70
Reproductive performance of Creole goats subjected to estrus synchronization protocols differing in duration and GnRH administration.
FindingPregnancy rate was 57.7% for short-term and 53.8% for long-term protocols.
Animal2026Full text read0.80
Lecirelin-cloprostenol: A single-dose compounding formulation for ovulation induction in beef cows.
FindingGPG reduced the dispersion of ovulation timing compared to GnRH alone (Bartlett's test, P<0.05), n=25.
Animal2026Full text read0.80
Effects of polystyrene microplastics and nanoplastics on the hypothalamic-pituitary-testicular axis of Japanese quail.
FindingNot reported in abstract.
Animal2026Full text read0.70
Recurrence after hysteroscopic myomectomy for FIGO type II submucosal myomas: a retrospective cohort study.
FindingBootstrap-corrected C-index of 0.811.
Human2026Full text read0.80
Effects of extending interval between presynchronization and breeding protocols and prostaglandin F2α administration before breeding protocol on reproductive performance of Holstein dairy cows during summer.
FindingPregnancy risk decreased with a two-day extension in interval (P < 0.05).
Animal2026Full text read0.80
Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR ® protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen
Finding82% (629/769) of cows expressed estrus prior to FTAI with 7 & 7 Synch vs 64% (492/769) with 7-day CO-Synch + CIDR, P=0.01.
Animal2020Full text read0.80
Effect of Treatment With Gonadoreline at the Embryo Transfer on Pregnancy Outcomes in Bovine.
FindingConception rate at 30 days: 45.8% in treated group vs control, p=0.03.
Animal2021Full text read0.80
Application of the subcutaneous triptorelin stimulation test for the diagnosis of central precocious puberty
FindingNot reported in abstract.
Human2023Full text read0.70
Ovarian response in water buffaloes induced to ovulate outside the breeding season
FindingP4 concentrations were > 3 ng/ml on Days 26 and 33 in the P4 + eCG group.
Animal2025Full text read0.80
Diagnostic performance of a simplified GnRH stimulation test in central precocious puberty: a multicentre study
FindingPeak LH ≥ 5 IU/L defined CPP diagnosis.
Human2026Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Gonadorelin (GnRH) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Gonadorelin (GnRH) is discussed should be drawn from it.

Articles mentioning Gonadorelin (GnRH)