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Gonadorelin (GnRH) record · updated 9h ago

Healing & recoveryNeuro & moodGrade A · human clinicalResearch use only
All 18 studiesJump to the evidenceCompare
What is Gonadorelin (GnRH) used for?

Gonadorelin is synthetic GnRH, a decapeptide that stimulates pituitary release of LH and FSH in pulsatile fashion — used diagnostically and to support the reproductive hormone axis.

How it works: GnRH receptor agonist

Primarily researched for · Healing & recoveryRoute · Subcutaneous injection

Development stage

where Gonadorelin (GnRH) sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 39 registered trials. It describes the research record, not a recommendation.

Identity
NameGonadorelin (GnRH)
Full name—
Sequence—
ClassHealing
Research levelModerate Research
Discovered byCurated master list · 2026
Pharmacology
MechanismGnRH receptor agonist
RouteSubcutaneous injection
Half-life~20 min
Time to peak—
Duration—
Extraction confidence0.90
Effect profile · 0–5
Healing & recovery: Healing 2.0, Muscle 0.0, Metabolic 0.0, Neuro 1.0, Sleep 0.0, Immune 0.0, Skin 0.0Healing & recovery — 2.0 / 5Neuro & mood — 1.0 / 5HealingMuscleMetabolicNeuroSleepImmuneSkin2.00.00.01.00.00.00.0
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o mini over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Jul 27, 2026. How this works →
Research stats
Total studies18
Human / animal / cellular11 / 7 / 0
Highest trial phasePreclinical
Years covered2020–2026
Latest study12d ago
Publication history
20202026
Research funding
1,075 NIH projects · $30.8M awarded · through FY2026
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

18 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Evaluation of the 7 & 7 Synch and 7-day CO-Synch + CIDR <sup>®</sup> protocols for estrus synchronization of beef cows prior to fixed-time artificial insemination with conventional or sex-sorted semen
Finding82% (629/769) of cows expressed estrus prior to FTAI with 7 & 7 Synch vs 64% (492/769) with 7-day CO-Synch + CIDR, P=0.01.
Animal2020Full text read0.80
Effect of Treatment With Gonadoreline at the Embryo Transfer on Pregnancy Outcomes in Bovine.
FindingConception rate at 30 days: 45.8% in treated group vs control, p=0.03.
Animal2021Full text read0.80
Application of the subcutaneous triptorelin stimulation test for the diagnosis of central precocious puberty
FindingNot reported in abstract.
Human2023Full text read0.70
Ovarian response in water buffaloes induced to ovulate outside the breeding season
FindingP4 concentrations were > 3 ng/ml on Days 26 and 33 in the P4 + eCG group.
Animal2025Full text read0.80
Diagnostic performance of a simplified GnRH stimulation test in central precocious puberty: a multicentre study
FindingPeak LH ≥ 5 IU/L defined CPP diagnosis.
Human2026Full text read0.80
Incidence study of precocious puberty in the population of the state of Goiás: did the COVID-19 pandemic modify the epidemiology?
Finding154% increase in treatment requests during the pandemic, p<0.001.
Human2026Full text read0.80
Pulmonary alveolar proteinosis diagnosed during leuprorelin acetate therapy for ovarian endometrioma: a case report.
FindingWhite blood cell nadir, 2.94 × 10⁹/L.
Human2026Full text read0.70
Study on the Association Between the Systemic Immune-Inflammation Index and Polycystic Ovary Syndrome in Women Undergoing in vitro Fertilization for Subfertility.
FindingOR=2.030, 95% CI: 1.079-3.819, P=0.028 for systemic immune-inflammation index (SII)
Human2026Full text read0.80
Stress-related cortisol and progesterone concentrations influence the success of ovulation induction in estrous cats.
FindingOvulation rates: VS 46.2%, GnRH 73.1%, hCG 100%, p<0.05.
Animal2026Full text read0.80
Assessing Long-Term Changes in Endometrial Morphology and Functionality in Dairy Cows With Metritis.
Finding63% prevalence of periglandular fibrosis in MET cows (95% CI = 25-92).
Animal2026Full text read0.80
Changing the route of GnRH administration according to the initial cyclic phase of the Ovsynch protocol may optimize reproductive outcomes in dairy cows.
Finding44.31% pregnancy rate after intramuscular administration in luteal phase vs 31.95%, P=0.083.
Human2026Full text read0.80
Hypothalamic-superior frontal gyrus functional connectivity alterations and luteinizing hormone correlations in girls with central precocious puberty.
FindingNot reported in abstract.
Human2023Full text read0.80

Articles mentioning Gonadorelin (GnRH)