Peptides DB

Research-centric peptide and protocol reference hub

GHK-Cu

Research-centric overview

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Peptide

Copper-binding tripeptide widely used in skin, hair, and wound-healing contexts, with systemic effects explored in research.

Community effect votes, structured logs, and side-effect summaries.

Effect profile (overview)

Aggregate AI baseline blended with community voting. Hover to inspect effect strengths per category.

Effect profile (AI + community): Healing & recovery 4.0/5 · Muscle & body comp 1.0/5 · Metabolic & appetite 3.0/5 · Neuro & mood 2.0/5 · Inflammation & immune 4.0/5 · Skin & aesthetics 5.0/5Healing 4.0Muscle 1.0Metabolic 3.0Neuro 2.0Sleep 0.0Inflammation 4.0Skin 5.0

Effect scores blend an AI baseline with community votes. Open the full chart to see sliders and vote on each category.

Research log summary heatmap

Compact view of how logs describe shifts in pain, sleep, and performance (−5 to +5). Treat this as qualitative, anonymous signal only.

Pain / discomfort0/5
Sleep / recovery0/5
Performance / output+2/5

Based on 10 anonymized research logs. Scroll down for full context and methodology.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

58%improved skin texture
16%localized irritation
13%transient tingling
3%gi upset
3%headache

Research footprint

Last analyzed Jun 2, 2026
9
Studies indexed
0
Human
2
Animal
9
AI analyzed
Evidence mix0% human · 22% animal · 0% cellular · 0% review
Highest phase: PreclinicalYears covered: 2026
Librarian pulse — latest actionsFull changelog ↓
  • Jun 2, 5:00 PMRe-scoredScored effects for GHK-Cu
  • Jun 2, 5:00 PMVerifiedVerified content for GHK-Cu: accurate
  • Jun 1, 7:01 AMVerifiedVerified content for GHK-Cu: accurate

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

The GHK-Cu delays aging in Caenorhabditis elegans via coordinated regulation of mitochondrial function and activation of DAF-16/SKN-1 pathways.StudyPubMedPublished Jan 1, 2026Added May 27, 2026

GHK-Cu treatment resulted in a 20% increase in lifespan in C. elegans, with improvements in mitochondrial function and activation of aging-related pathways.

A Phase 2, Randomized, Double-Blind, Vehicle-Controlled, Split-Wound Study of Topical GHK-Cu (Copper(II)-Peptide Complex) Gel to Accelerate Re-Epithelialization of Standardized Acute Skin Wounds in Healthy AdultsClinical TrialClinicalTrials.govPublished Feb 2, 2026Added Apr 16, 2026

This study evaluated the effects of topical GHK-Cu gel on re-epithelialization of standardized acute skin wounds in healthy adults. The study was designed as a Phase 2, randomized, double-blind, vehicle-controlled trial. Not reported in abstract.

Phase: PHASE2Status: RECRUITING
A Phase IV Open-label Trial Assessing the Impact on Skin Quality, Hydration, and Barrier of Three (3) Hydrafacial Treatments in Adults of Fitzpatrick Skin Types I-VIClinical TrialClinicalTrials.govPublished Nov 20, 2023Added Apr 16, 2026

This study assessed the impact of three Hydrafacial treatments on skin quality, hydration, and barrier function in adults of Fitzpatrick Skin Types I-VI. The trial was open-label and classified as Phase IV. No therapeutic claims were made.

Phase: PHASE4Status: COMPLETED
Semantic Scholar search for GHK-CuStudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Copper Complexes with New Glycyl-l-histidyl-l-lysine-Hyaluronan Conjugates Show Antioxidant Properties and Osteogenic and Angiogenic Synergistic Effects.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Popular stacks

Most commonly stacked peptides based on community research logs.

External databases

Helpful external resources for additional structural, pharmacologic, and literature context. These are third-party databases; always cross-check details with primary research.

Community notes

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Community research logs (detail)

Showing the latest 5 logs out of 10.

Goal: injury / tissue repair

Context: recreational 26-35

Duration ~6.0 weeks

Δ scores
Pain +1Sleep +0Perf +1

GHK-Cu used on scar tissue around an old surgical site alongside massage and basic rehab work. Subjective improvement in scar pliability and local tightness.

Goal: skin / cosmetic

Context: sedentary / light 36-45

Duration ~8.0 weeks

Δ scores
Pain +0Sleep +1Perf +0

Topical GHK-Cu cream to face and neck most evenings. Tracking skin texture, fine lines, and general 'glow' with photos; also paying attention to irritation or breakouts.

Goal: joint / tendon comfort

Context: unspecified training level age not given

Duration not specified

Δ scores
Pain -4Sleep -3Perf +5

Goal: injury / tissue repair

Context: unspecified training level age not given

Duration not specified

Δ scores
Pain +1Sleep +0Perf +0

Goal: injury / tissue repair

Context: unspecified training level age not given

Duration not specified

Δ scores
Pain +0Sleep +0Perf +3

How to read these logs

Each entry is a single, anonymized “n=1” summary with relative change sliders from −5 to +5. Higher positive values indicate perceived improvement; negative values indicate perceived worsening.

Context (training level, age band, duration, and dosing frequency) is shown so you can quickly skim for patterns or outliers. Treat this as qualitative signal layered on top of study data, not as a substitute for controlled trials.

Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

Use the "Report side effects" button to open a focused popup form. Please keep descriptions neutral and avoid medical language; think in terms of "nausea", "flushing", "vivid dreams", etc.

Quick tone breakdown of submitted side-effect tags:

PositiveNegativeNeutral / mixed

Top reported tags so far (color reflects tone):

58%improved skin texture
16%localized irritation
13%transient tingling

Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

0m agoScoring70%

Scored effects for GHK-Cu

0m agoVerificationai-researcher90%

Verified content for GHK-Cu: accurate

1d agoVerificationai-researcher90%

Verified content for GHK-Cu: accurate

May 26Scoring70%

Scored effects for GHK-Cu

May 26Refreshai-researcher85%

Refreshed content for GHK-Cu

Apr 16Refreshai-researcher85%

Refreshed content for GHK-Cu