Research library

A Systematic Review of the Mechanisms and Therapeutic Applications of GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper Complex) in Topical Microneedle Delivery: A Case for Expanded Clinical Trials.

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GHK-Cu · Archives of internal medicine research · 2026 · Review

There is a critical need for well-designed human trials to assess the efficacy of GHK-Cu delivered via microneedles, as current evidence is largely preclinical.

Not reported in abstract.

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Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells.

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GHK-Cu · Nature · 1980Top journal

Not reported in abstract.

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The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I).

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GHK-Cu · Science (New York, N.Y.) · 1996Top journal

Not reported in abstract.

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The Regenerative Potential of GHK-Cu in Aesthetic Medicine.

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GHK-Cu · Aesthetic surgery journal · 2026 · Systematic review

GHK-Cu shows potential as a regenerative agent in aesthetic medicine, but more rigorous clinical trials are needed to establish its efficacy and safety.

Not reported in abstract.

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Defining biomaterial-driven design principles for bioabsorbable flow diverters: current state and perspectives.

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GHK-Cu · Bioactive materials · 2026 · Review

Bioabsorbable flow diverters may improve aneurysm management by balancing scaffold resorption with mechanical integrity, but further research is needed to validate these design principles.

Not reported in abstract.

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A brain-targeted biomimetic iron-porphyrin covalent organic framework nanoplatform for Alzheimer's disease: synergistic intervention via antioxidant, Aβ-regulating and immunomodulatory effects.

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GHK-Cu · Journal of colloid and interface science · 2026 · Observational · Preclinical

This study presents a novel nanoplatform that targets multiple pathways in Alzheimer's disease, showing promise in animal models without making definitive treatment claims.

Copper-ion chelation rate of 41.78%.

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Systemic Copper Chelation Reduces Collagen Deposition and Preserves Secretory Function in Irradiated Mouse Salivary Glands.

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GHK-Cu · Advances in radiation oncology · 2026 · Observational · Preclinical

Systemic administration of tetrathiomolybdate may help preserve salivary gland function after radiation therapy in mice, but further research is needed to confirm these effects in humans.

Not reported in abstract.

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Asymmetric-interfacial nanofibrous membranes with diode-like exudate transport for nanozyme-catalyzed antibacterial wound healing.

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GHK-Cu · Biomaterials · 2026 · Observational · Preclinical

The study presents a novel wound dressing that achieved 99.8% closure in a murine model of antibiotic-resistant infection, but its applicability to human wounds is not yet established.

99.8% wound closure by day 12.

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Superconducting 2D cuprate with a single CuO(2) plane.

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GHK-Cu · Nature · 2026Top journal

Reducing the dimensionality of cuprates to a single CuO2 plane results in a significant reduction in superconducting transition temperature, highlighting the importance of dimensionality in superconductivity.

Approximately 10% reduction in optimal superconducting transition temperature.

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Ultralong sheathed single-metal-atom chains synthesized under high pressure.

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GHK-Cu · Science (New York, N.Y.) · 2026Top journal

Not reported in abstract.

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Ultrasensitive low-density lipoprotein monitoring in early cardiovascular risk assessment via Cu-MOF-Apt/MoS₂ fluorescent nanosensor.

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GHK-Cu · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2026 · Observational

This study presents a new fluorescent sensor that can detect LDL levels as low as 0.0789 ng/mL, potentially improving early cardiovascular risk assessment.

ultra-low detection limit (0.0789 ng/mL)

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pH and temperature-dependent structural and functional stability of hemocyanin from Tachypleus gigas: A multispectroscopic, phenoloxidase activity and computational study.

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GHK-Cu · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2026 · Observational

Tachypleus gigas hemocyanin retains 80% phenoloxidase activity up to 70 °C, indicating notable stability under varying conditions.

80% phenoloxidase activity up to 70 °C.

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Room-temperature multiferroicity in all-van der Waals heterostructures.

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GHK-Cu · Science (New York, N.Y.) · 2026Top journal

Not reported in abstract.

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Mining triggers extensive additional deforestation in sub-Saharan Africa.

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GHK-Cu · Nature · 2026Top journal

Not reported in abstract.

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Orbital magnetoresistance in the antiferromagnet CoO driven by dynamic orbital angular momentum.

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GHK-Cu · Science (New York, N.Y.) · 2026Top journal

Not reported in abstract.

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Surface-dominant transport in Weyl semimetal NbAs nanowires for next-generation interconnects.

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GHK-Cu · Science (New York, N.Y.) · 2026Top journal

Not reported in abstract.

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Partial substitution of organic trace minerals in sow diets over multiple parities and the impact on claw health, productivity, and longevity.

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GHK-Cu · Veterinary and animal science · 2026 · Observational · n=344

Supplementing sow diets with organic trace minerals may reduce lactation weight loss and the odds of claw lesions, but it does not appear to impact longevity or lameness significantly.

Lactation weight loss decreased with treatment (P = 0.02).

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The GHK-Cu delays aging in Caenorhabditis elegans via coordinated regulation of mitochondrial function and activation of DAF-16/SKN-1 pathways.

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GHK-Cu · Biogerontology · 2026 · Preclinical · n=200

GHK-Cu appears to extend lifespan and improve aging-related functions in C. elegans, but its relevance to human aging is not established.

Not reported in abstract.

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Hierarchical regulation and mechanism of "open-hollow-fibrous network" structures: Osteogenic-angiogenic coupling responses of poly(γ-benzyl-L-glutamate) microspheres.

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GHK-Cu · PubMed · 2026 · Observational

PBLG-GCu HNMs showed enhanced osteogenic gene expression in BMSCs, but further research is needed to determine their clinical relevance.

Runx2 expression increased by 1.61-fold, OPN by 3.53-fold, and OCN by 2.29-fold compared to non-functionalized PBLG HNMs.

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Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs

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GHK-Cu · biorxiv-preprint · 2026 · Observational · Preclinical

GHK-Cu shows potential for improving cognitive function in aged mice, with intranasal administration yielding more consistent results than intraperitoneal dosing.

IN treatment increased synaptophysin in females (P < 0.001).

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Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs

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GHK-Cu · biorxiv-preprint · 2026 · Observational · Preclinical

GHK-Cu administered intranasally improved cognitive function in aged mice, while intraperitoneal administration showed only temporary benefits.

IN GHK-Cu improved escape latency across Trials 2–4, p<0.05.

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Hierarchical regulation and mechanism of "open-hollow-fibrous network" structures: Osteogenic-angiogenic coupling responses of poly(γ-benzyl-L-glutamate) microspheres.

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GHK-Cu · europepmc · 2026 · Observational

The study suggests that GHK-Cu functionalized microspheres could enhance bone tissue engineering efforts, but further research is needed to confirm these findings in vivo.

Runx2 expression increased by 1.61-fold, OPN by 3.53-fold, and OCN by 2.29-fold compared to non-functionalized PBLG HNMs.

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The GHK-Cu delays aging in Caenorhabditis elegans via coordinated regulation of mitochondrial function and activation of DAF-16/SKN-1 pathways.

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GHK-Cu · PubMed · 2026 · Observational · Preclinical · n=100

GHK-Cu appears to extend lifespan and improve aging-related functions in C. elegans, but these findings need further investigation in human studies to assess their relevance.

Not reported in abstract.

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Partial text

Semantic Scholar search for GHK-Cu

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GHK-Cu · SemanticScholar

Not reported in abstract.

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