Research library

B

grade

Combination therapy with GnRHa and growth hormone shows the most promise for improving predicted adult height in boys with accelerated pubertal progression. Aromatase inhibitors may serve as a viable alternative for certain patients.

ΔH/y of combination therapy was 8.49 ± 3.22 cm/y, GnRHa was 6.73 ± 1.95 cm/y, and AI was 7.75 ± 1.92 cm/y, P < 0.01.

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B

grade

This study found no significant changes in perceived stress levels after 3 or 12 months of gender-affirming hormone therapy, indicating that improvements in well-being may not reduce stress.

No significant changes in perceived stress were observed after 3 months (-1.0, p = 0.21).

summary

C

grade

Triptorelin treatment in adolescent rats leads to increased liver injury and fibrosis, with distinct responses observed between males and females. Further research in humans is needed to assess the relevance of these findings.

Not reported in abstract.

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B

grade

Triptorelin may delay ovulation by about one week in the natural cycle following ovarian stimulation, which could affect the timing of frozen embryo transfers.

Ovulation was delayed to cycle day 21, compared to the predicted cycle day 14.

summary

C

grade

Triptorelin treatment during puberty leads to reproductive suppression and distinct metabolic changes in male and female rats, indicating broader neuroendocrine effects beyond reproductive maturation.

Not reported in abstract.

summary