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A tumour-derived organoid biobank maps cancer gene dependencies.
P21 (P021) · Nature · 2026Top journal
Not reported in abstract.
Research library
Every indexed study on every peptide in the database, with a machine summary and the numbers that matter pulled out. Filter on the left; the register updates as you go.
2423studies indexed1086with human data145registered trials2091carry a numeric findingLibrarian added 0 studies today
Showing 24 studiesSortNewest indexed ▾
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Genotoxic and metabolic stress drive divergent senescence programs in human microglia
P21 (P021) · biorxiv-preprint · 2026 · Observational
Chronic genotoxic and metabolic stress induce different senescence programs in human microglia, which may have implications for neurodegenerative diseases.
Not reported in abstract.
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Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis
P21 (P021) · biorxiv-preprint · 2026 · Observational
This research suggests that p53 activity and cholesterol contribute to liver and systemic fibrosis in a sex-specific manner, particularly in male mice.
Not reported in abstract.
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Cell cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors
P21 (P021) · biorxiv-preprint · 2026 · Observational
Extending the G1 phase in cancer cells may create new vulnerabilities for treatment, particularly through the combination of CDK inhibition and LSD1 inhibition.
Not reported in abstract.
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Punicalagin alleviates senile osteoporosis by inhibiting the senescence of bone mesenchymal stem cells via NRF2/HO-1 pathway.
P21 (P021) · Regenerative therapy · 2026 · Animal study
Punicalagin may help reduce the aging-related decline in bone health by affecting bone mesenchymal stem cells, but further research is needed to confirm these effects in humans.
Not reported in abstract.
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Prognostic risk modeling based on integrated multi-omics analysis identifies CRY2 as a key regulator in tumor immunity and patient survival in colorectal cancer.
P21 (P021) · Annals of medicine · 2026 · Observational
The study found that a prognostic model based on ferroptosis and lipid metabolism can predict survival outcomes in colorectal cancer, with CRY2 identified as a key regulator.
HR > 1.1, p < 0.001 for RiskScore as an independent predictor of overall survival.
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Daraxonrasib for Previously Treated RAS-Mutant Non-Small-Cell Lung Cancer.
P21 (P021) · The New England journal of medicine · 2026Top journal
Not reported in abstract.
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Progressive Left Ventricular Pressure Overload Reprograms Neonatal Left Ventricular Development via Sustained Proliferation, Metabolic Arrest, and Compensatory Angiogenesis
P21 (P021) · biorxiv-preprint · 2026 · Observational
Progressive left ventricular pressure overload in neonatal rats reprograms heart development by sustaining cardiomyocyte proliferation and altering metabolic pathways.
3,132 DEGs under overload conditions at P7 compared to P3.
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Dual Pharmacological Inhibition of PAK1 and CaMKII Cooperatively Suppresses Malignant Phenotypes in Glioblastoma Cells
P21 (P021) · biorxiv-preprint · 2026 · Observational
Dual inhibition of PAK1 and CaMKII shows promise in enhancing anti-tumor effects in glioblastoma cell lines, but further research is needed to assess its clinical relevance.
Mean synergy scores: 12.07 (U251), 13.91 (U87), and 14.25 (T98G) using HSA model.
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A novel target associated with senescence and inflammatory signaling in human intervertebral disc degeneration
P21 (P021) · biorxiv-preprint · 2026 · Observational
High levels of connexin 43 in intervertebral discs are linked to cellular senescence and inflammation, suggesting it may be a target for future research on IDD.
Not reported in abstract.
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Sex differences in senescence burden within human osteoarthritic synovial fibroblasts
P21 (P021) · biorxiv-preprint · 2026 · Observational
Female synovial fibroblasts show higher levels of senescence markers and a reduced ability to handle oxidative stress, which may help explain the increased risk of osteoarthritis in women.
Not reported in abstract.
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Novel senolytic and senescence-suppressing compounds overcome senescence-driven chemoresistance in NSCLC
P21 (P021) · biorxiv-preprint · 2026 · Observational
Targeting therapy-induced senescence may enhance the effectiveness of chemotherapy in NSCLC, but further clinical studies are needed to validate these findings.
15 - 30% response rates to platinum-based regimens in advanced NSCLC.
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Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer.
P21 (P021) · Nature medicine · 2026 · ObservationalTop journal
Over half of the patients treated with daraxonrasib showed genomic alterations linked to resistance, suggesting the need for combination therapies to address these changes.
59% of patients (26 of 44) showed treatment-emergent genomic alterations in the RAS signaling pathway.
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Structure-based screening and identification of a novel Aurora-A-targeting peptide with antiproliferative activity against prostate cancer cells.
P21 (P021) · Journal of enzyme inhibition and medicinal chemistry · 2026 · Observational
Peptide-1 shows potential as an Aurora-A-targeting peptide with antiproliferative effects in prostate cancer cell lines, but clinical relevance is not established.
Kd = 0.72 ± 0.04 μM for Peptide-1 binding to Aurora-A.
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Author Correction: p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
P21 (P021) · Nature metabolism · 2026Top journal
Not reported in abstract.
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Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle.
P21 (P021) · Science (New York, N.Y.) · 2026Top journal
Not reported in abstract.
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Bleomycin as an Inducer of Senescence in RAW 264.7 Macrophages
P21 (P021) · biorxiv-preprint · 2026 · Observational
Bleomycin can induce macrophage senescence without triggering inflammatory activation, making it a useful tool for studying senescence in vitro.
80% senescence-associated beta-galactosidase (SA-β-gal) positivity with bleomycin.
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Overexpression of LINC00472 alleviates diabetic kidney disease progression via the miR-21-5p/STAT3 axis.
P21 (P021) · Renal failure · 2026 · Observational · n=214
LINC00472 appears to be downregulated in diabetic kidney disease and may correlate with renal function indicators, but further research is needed to clarify its role and potential as a diagnostic marker.
Not reported in abstract.
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Discovery of a novel and potent KRAS<sup>G12V</sup>-targeting peptide with antiproliferative activity against colorectal cancer cells.
P21 (P021) · Journal of enzyme inhibition and medicinal chemistry · 2026 · Observational
Peptide-1 shows promise as a KRAS<sup>G12V</sup>-targeting peptide in colorectal cancer, but further research is needed to validate its efficacy in clinical settings.
Not reported in abstract.
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Lysozyme revisited: evaluating models of a reference protein in structural biology.
P21 (P021) · Current research in structural biology · 2026 · Observational
The study found no correlation between R_free and R_merge for lysozyme structures, indicating potential issues with structure quality in the Protein Data Bank.
Not reported in abstract.
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Recombinant human collagen XVII protects epidermal stem cells from blue light-induced photoaging by downregulating the Notch pathway.
P21 (P021) · Annals of medicine · 2026 · Animal study · Preclinical
RhCol17 shows potential in protecting against blue light-induced skin aging in preclinical models, but human studies are needed to confirm its efficacy.
Not reported in abstract.
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Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder.
P21 (P021) · europepmc · 2024 · Observational
P021 showed promise in restoring neuronal deficits in vitro, but chronic treatment in vivo did not yield significant improvements in BDNF levels or neuroanatomical defects in CDKL5 deficiency disorder models.
Not reported in abstract.
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Evaluation of the Biological Effect of a Nicotinamide-Containing Broad-Spectrum Sunscreen on Photodamaged Skin.
P21 (P021) · europepmc · 2008 · Observational
The study found no statistically significant changes in skin parameters after using a nicotinamide sunscreen for 4 weeks, despite some trends in gene expression.
Not reported in abstract.
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SMN1 variants identified by false-positive SMA newborn screening tests: Therapeutic hurdles and functional and epidemiological solutions.
P21 (P021) · europepmc · 2026 · Observational
This research indicates that some infants with SMN1 variants may not develop SMA, suggesting that low levels of a novel SMN isoform can support normal motor development.
Not reported in abstract.
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