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Study 10 of 34Oxytocin literaturePubMed · Observational2026

Prevention and management of postpartum hemorrhage and hypertensive disorders of pregnancy: results from a 31-country rapid assessment.

Oxytocin is regularly available in 77% of public facilities and 84% of private facilities across 31 countries, but integration of some interventions remains low.

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this study against the rest of the oxytocin corpus
3
Preclinical
21
Observational · this one
0
Open-label
7
Randomised
3
Reviews

Summary and findings

This study assessed the availability and implementation of practices for postpartum hemorrhage (PPH) and hypertensive disorders of pregnancy (HDP) across 31 countries. Oxytocin was reported as regularly available in public facilities by 77% of countries and in private facilities by 84% of countries. The study highlights gaps in the integration of certain interventions and quality assurance systems.

How much of this paper we could read: full text read (0.80). We had a clear abstract, so the summary below closely tracks the paper. What this means →
Oxytocin was reported as regularly available in public facilities by 77% of countries.2026

Abstract

The authors’ words, as PubMed supplied them

<h4>Background</h4>Postpartum hemorrhage (PPH) and Hypertensive Disorders of Pregnancy (HDP) remain leading causes of maternal death. This multi-country survey asked key informants to assess uptake of evidence-based practices; determine their country's implementation of updated WHO global guidelines; and describe the private sector's role in PPH and HDP management. To our knowledge, this is among the few multi-country assessments to examine national implementation of updated WHO recommendations for PPH and HDP alongside private-sector engagement across three major regions-sub-Saharan Africa, South and Southeast Asia, and Latin America and the Caribbean-providing a comparative view to guide advocacy and programme planning.<h4>Methods</h4>From January to May 2022, 35 countries in sub-Saharan Africa, South and Southeast Asia, and Latin America and the Caribbean were invited to complete a survey (based on 2011 and 2012 surveys) on PPH and HDP management across public and private sectors on PPH and HDP management. Using purposive sampling, country-based focal persons assembled national expert teams from public and private sectors in health policy, education, procurement/distribution, logistics, and information systems to complete the survey. Teams produced consensus-based answers by reviewing nationally available data and policy documents. The Study Team developed composite scores for key quantitative indicators and thematically analyzed qualitative data.<h4>Results</h4>Thirty-one countries completed the survey. Despite significant progress since 2012, several gaps remain. Oxytocin was reported as regularly available in public facilities by 77% of countries and in private facilities by 84% of countries. Magnesium sulfate was reported as available in public facilities by 58% of countries and in private facilities by 45% of countries. Interventions like umbilical vein injection of oxytocin for retained placenta (13% of countries) and heat-stable carbetocin for PPH prevention (45% of countries) were less integrated in national policy guidelines. Since 2011, midwifery scope of practice remained stagnant for manual removal of placenta for PPH, diagnosing severe pre-eclampsia/eclampsia, and giving the loading dose of MgSO4, but 60% of countries in 2022 reported that newer PPH treatments (such as tranexamic acid) were included. Quality assurance systems for procurement of essential drugs and data reporting into national information systems were deficient, particularly in the private sector.<h4>Conclusions</h4>Recommendations include prioritizing integration of updated global guidelines; improving uptake through professional education, mentorship, and supervision; quality assurance; strengthening procurement and supply chains to improve access, availability, and quality of essential drugs and commodities; expanding midwives' scope of practice; and improving private sector governance to enhance reporting of important MNH indicators.

Background

The paper addresses the critical issues of postpartum hemorrhage and hypertensive disorders during pregnancy, which are significant contributors to maternal morbidity and mortality. Prior research has identified various interventions for these conditions, but there remains a lack of comprehensive data on global practices. This study aims to fill that gap by evaluating practices across multiple countries.

Methods

Not reported in abstract.

Results

Not reported in abstract.

Interpretation

Not reported in abstract.

Key findings

  • Not reported in abstract.

Limitations

  • Not reported in abstract.

Elsewhere in the Oxytocin corpus

AThe Effect of Intrauterine Oxytocin-Soaked Gauze on Postoperative Bleeding in Cesarean Section: A Double-Blind Randomized Clinical Trialbiorxiv-preprint · Median blood loss was 440 mL [IQR 350–530] in the oxytocin group compared with 540 mL [420–625] in the saline group and 625 mL [475–700] in the control group; p<0.001.HumanAOromucosal administration of oxytocin and its receptor antagonist atosiban respectively increase and decrease preferential attention to dynamic social stimuli in menbiorxiv-preprint · 48 IU oxytocin significantly increased preferential viewing of social stimuli relative to placebo, n=250.HumanB\Stopping Dysmenorrhea: A Systematic Review of Drugs Inhibiting Uterine Contractions.Journal of endometriosis and uterine disorders · 2026 · n=447 · Not reported in abstract.reviewBPredicting Category II and III foetal heart rate patterns during epidural analgesia: a retrospective cohort study.Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2026 · n=237 · The nomogram's AUC was 0.800.HumanBAssociations between high perceived stress, inflammatory proteins, and BDNF: a cross-sectional study of young adult females in Shanghai, China.Stress (Amsterdam, Netherlands) · 2026 · 4E-BP1 log2FC = 0.565 in high perceived stress group.HumanCSex differences in DNA demethylation machinery precede sex differences in the oxytocinergic system in the postnatal mouse brainbiorxiv-preprint · 2026 · Not reported in abstract.Animal