The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies.
The serum showed significant improvements in static and dynamic wrinkles and various aspects of skin quality after 12 weeks, but the clinical relevance of these changes may vary.
Where it sits
this study against the rest of the argireline corpusSummary and findings
This study evaluated the effects of a serum containing acetyl hexapeptide-8 and other ingredients on skin biomarkers and wrinkles in human subjects. The serum was tested in two clinical studies with 50 and 42 participants, respectively. Significant improvements in skin quality and wrinkle appearance were reported after 12 weeks of use.
Abstract
<h4>Objective</h4>This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.<h4>Methods</h4>In ex-vivo study, skin samples were exposed to the serum (Formula 1) and its active ingredient combinations (Formula 2). Biomarkers including matrix metalloproteinase-1, elastic fibres and collagen types I, III, IV and XVII content were analyzed to evaluate the efficacy. In clinical study 1 (n = 50), the Formula 1's efficacy in reducing static wrinkles and improving skin quality was examined, while study 2 (n = 42) focused on its efficacy against dynamic wrinkles.<h4>Results</h4>Formula 1 significantly increased levels of anti-aging biomarkers including elastic fibres, collagen fibres, etc. Meanwhile, Formula 1 significantly improved static wrinkle appearance within the first week, with mean clinical scoring from 35% to 69% for various types of wrinkles after 12 weeks of use (all p < 0.001). The clinical scoring for dynamic wrinkles improved by 10%-13% (all p < 0.001). Additionally, significant improvements were observed in skin quality, indicated by clinical scoring changes of smoothness (30%), radiance (27%), skin pore (43%), elasticity (33%) and firmness (36%) (all p < 0.001).<h4>Conclusion</h4>The serum demonstrates significant anti-aging effects, effectively improving static and dynamic wrinkles and skin quality.
Background
This paper addresses the efficacy of a serum containing multiple peptides and other ingredients aimed at reducing skin aging signs. Prior studies have indicated that various peptides can influence skin properties, but comprehensive evaluations of combined formulations are limited. This study is significant as it combines both ex-vivo and clinical data to assess the serum's effects on skin biomarkers and appearance.
Methods
The study included an ex-vivo analysis of skin samples treated with the serum and its active components. Two clinical studies were conducted: the first with 50 participants assessing static wrinkles and skin quality, and the second with 42 participants focusing on dynamic wrinkles. The duration of treatment was 12 weeks, with primary outcomes including changes in wrinkle appearance and skin quality metrics.
Results
The primary endpoint showed that the mean clinical scoring for static wrinkles improved from 35% to 69% after 12 weeks of use, n=50, p<0.001. Additionally, dynamic wrinkles improved by 10%-13%, n=42, p<0.001. Significant improvements in skin quality were also noted, including smoothness (30%), radiance (27%), pore size (43%), elasticity (33%), and firmness (36%), all with p<0.001.
Interpretation
The findings suggest that the serum may have a statistically significant effect on reducing wrinkles and improving skin quality. However, the clinical significance of these improvements, particularly for dynamic wrinkles, may be limited given the modest percentage changes. The study's small sample sizes and lack of long-term follow-up may confound the conclusions drawn.
Key findings
- mean clinical scoring for static wrinkles improved from 35% to 69% after 12 weeks of use, n=50, p<0.001
- dynamic wrinkles improved by 10%-13% after treatment, n=42, p<0.001
- clinical scoring changes for smoothness improved by 30%, p<0.001
- radiance improved by 27%, p<0.001
- skin pore size reduced by 43%, p<0.001
- elasticity improved by 33%, p<0.001
- firmness improved by 36%, p<0.001
Limitations
- small n=50 for static wrinkles and n=42 for dynamic wrinkles
- 12-wk follow-up too short to see durability
- no long-term effects reported
- potential conflicts of interest not disclosed