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Argireline

Research-centric overview

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### Summary Argireline, also known as Acetyl Hexapeptide-3, is a synthetic peptide commonly utilized in cosmetic formulations for its potential anti-aging properties. It is often marketed as a topical alternative to botulinum toxin, aiming to reduce the appearance of fine lines and wrinkles.

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Research log summary heatmap

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Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

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Research footprint

Last analyzed Jun 2, 2026
6
Studies indexed
0
Human
1
Animal
6
AI analyzed
Evidence mix0% human · 17% animal · 0% cellular · 0% review
Highest phase: Preclinical onlyYears covered: 2026
Librarian pulse — latest actionsFull changelog ↓
  • Jun 2, 6:00 AMRefreshedRefreshed content for Argireline
  • May 28, 6:01 AMRefreshedRefreshed content for Argireline
  • May 27, 6:04 AMRefreshedRefreshed content for Argireline

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of BlepharospasmClinical TrialClinicalTrials.govPublished Jul 1, 2009Added May 27, 2026

The study evaluated the effects of Acetyl Hexapeptide-8 (AH8) on blepharospasm. The population and specific dosages were not detailed in the abstract. Outcomes related to the treatment's efficacy were assessed.

Phase: PHASE1, PHASE2Status: COMPLETED
Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care CreamClinical TrialClinicalTrials.govPublished Apr 1, 2019Added Apr 16, 2026

This study investigated the wrinkle reduction potential of a novel compounded skin care cream containing Argireline. The trial involved human subjects, but specific details on the sample size and dosage were not reported. The outcomes related to wrinkle reduction were assessed, but no specific numeric results were provided in the abstract.

Phase: EARLY_PHASE1Status: COMPLETED
A Clinical Trial to Evaluate the Effects of an Eye Serum on Improving the Appearance of the Periorbital AreaClinical TrialClinicalTrials.govPublished Aug 21, 2023Added Apr 16, 2026

This study evaluated the effects of an eye serum on improving the appearance of the periorbital area. The specific dose and duration of treatment were not reported in the abstract. The outcomes measured included various parameters related to the appearance of the skin around the eyes.

Phase: NAStatus: COMPLETED
Efficacy and Safety of Topical Argireline in the Treatment of Periorbital WrinklesClinical TrialClinicalTrials.govPublished Mar 1, 2009Added Apr 16, 2026

This study evaluated the efficacy and safety of topical Argireline in treating periorbital wrinkles. The population and specific dosage were not detailed in the abstract. The findings regarding efficacy and safety are not reported in abstract.

Phase: PHASE3Status: COMPLETED
Placebo Controlled Double Blind Study of Acetyl Hexapeptide-8 in Treatment of BlepharospasmClinical TrialClinicalTrials.govPublished Nov 1, 2012Added Apr 16, 2026

The study evaluated the effects of Acetyl Hexapeptide-8 on blepharospasm in a placebo-controlled, double-blind design. The specific dose and duration of treatment were not reported in the abstract. The outcomes measured included the severity of blepharospasm symptoms.

Phase: PHASE2Status: TERMINATED
Pilot Randomized Double-Blind Controlled Trial of Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily SkinClinical TrialClinicalTrials.govPublished Jan 1, 2016Added Apr 16, 2026

This pilot study evaluated the effects of topical Acetyl Hexapeptide-8 on the cosmetic appearance of oily skin. The study involved participants with oily skin, although specific demographic details were not provided. Not reported in abstract.

Phase: NAStatus: COMPLETED
Semantic Scholar search for ArgirelineStudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

INDIVIDUAL ARTICLE: Real-World Clinical Experience With a Neuro-Peptide Serum in Combination With Botulinum Toxin Type-A Injections.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Acetyl Dipeptide-31 Amide: A Novel Cosmetic Anti-Inflammatory Peptide That Demonstrates Anti-Aging, Firming, and Lifting Benefits.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model.StudyPubMedAdded Dec 12, 2025

The study explores the effects of BAK and Argireline in a zebrafish model, but specific outcomes and their implications for human use are not detailed.

External databases

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Community research logs (detail)

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Anonymous side-effect reporting (detail)

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Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

11h agoRefreshai-researcher85%

Refreshed content for Argireline

5d agoRefreshai-researcher85%

Refreshed content for Argireline

6d agoRefreshai-researcher85%

Refreshed content for Argireline

May 26task_runlibrarian-runner

Completed task: Find real articles for Argireline (thin literature)

May 26Ingestiondiscovery

Searched for real articles on Argireline

Apr 20task_runlibrarian-runner

Completed task: Refresh content for Argireline

Apr 20Refreshdiscovery50%

Refreshed content for Argireline

Apr 20SummaryPubMed20%

Auto-summarized study: "BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant B..."

Apr 20SummaryPubMed0%

Auto-summarized study: "Acetyl Dipeptide-31 Amide: A Novel Cosmetic Anti-Inflammatory Peptide That Demon..."

Apr 20SummaryPubMed10%

Auto-summarized study: "INDIVIDUAL ARTICLE: Real-World Clinical Experience With a Neuro-Peptide Serum in..."

Apr 20SummarySemanticScholar0%

Auto-summarized study: "Semantic Scholar search for Argireline..."