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Study 1 of 9Melanotan II literaturePubMed · Case report2025

Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?

Melanotan II nasal spray may pose serious risks, including the potential development of malignant melanoma, as evidenced by this case report.

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Where it sits

this study against the rest of the melanotan ii corpus
3
Preclinical
6
Observational · this one
0
Open-label
0
Randomised
0
Reviews

Summary and findings

This case report describes a 22-year-old female who developed a mass in the anterior maxilla after using Melanotan II nasal spray for tanning. Histological analysis confirmed a diagnosis of mucosal malignant melanoma, leading to surgical resection and ongoing immunotherapy. The report emphasizes the potential risks associated with Melanotan II use.

How much of this paper we could read: full text read (0.70). We had a clear abstract, so the summary below closely tracks the paper. What this means →
Not reported in abstract.2025

Abstract

The authors’ words, as PubMed supplied them

The case of a 22-year-old female who developed a mass in the anterior maxilla after using Melanotan II, a nasal spray containing a synthetic analogue of melanocyte-stimulating hormone, is reported. The patient had used the nasal spray for tanning purposes. Melanotan II is unlicensed, and its sale is illegal in the United Kingdom and in many other countries around the world. Histological analysis confirmed the diagnosis of a mucosal malignant melanoma. The patient subsequently underwent surgical resection followed by ongoing immunotherapy. The clinical presentation and initial management of the patient, along with a literature review on the potential association between Melanotan use and the development of malignant melanoma, is provided. This report highlights the need for awareness of the possible serious side effects associated with Melanotan II nasal spray.

Background

The paper addresses the concern of whether Melanotan II nasal spray could be a risk factor for developing oral mucosal malignant melanoma. Previous studies have indicated potential risks associated with Melanotan II, but the specific implications for oral mucosal health remain underexplored. This study aims to fill that gap by examining the relationship between Melanotan II use and melanoma incidence.

Methods

Not reported in abstract.

Results

Not reported in abstract.

Interpretation

Not reported in abstract.

Key findings

  • Not reported in abstract.

Limitations

  • Not reported in abstract.

Elsewhere in the Melanotan II corpus

CAssociation of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken.europepmc · 2026 · Not reported in abstract.AnimalCLow dose systemic AAV-exendin-4 gene therapy for Prader-Willi syndrome and dietary obesity.europepmc · 2026 · Not reported in abstract.AnimalBFive primary melanomas in situ in a patient with recent tanning bed use, melanotan exposure, and anabolic hormone use.europepmc · 2026 · n=1 · Not reported in abstract.HumanCMelanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for foodbiorxiv-preprint · 2022 · n=20 · Not reported in abstract.AnimalBChanges in Oral Mucosa Associated with Melanotan II Injections: A Case Report.PubMed · 2026 · Not reported in abstract.HumanDSemantic Scholar search for Melanotan IISemanticScholar