Melanotan II

Research-centric overview

Peptide

### Summary Melanotan II is a synthetic analog of the naturally occurring peptide hormone alpha-melanocyte-stimulating hormone (α-MSH), primarily studied for its effects on skin pigmentation and potential therapeutic applications. Research has also explored its impact on mood and stress responses, though caution is advised due to potential side effects and safety concerns.

Community effect votes, structured logs, and side-effect summaries.

Effect profile (overview)

Aggregate AI baseline blended with community voting. Hover to inspect effect strengths per category.

Effect scores blend an AI baseline with community votes. Open the full chart to see sliders and vote on each category.

Research log summary heatmap

Compact view of how logs describe shifts in pain, sleep, and performance (−5 to +5). Treat this as qualitative, anonymous signal only.

No community research logs yet. When structured logs are added, this panel will summarize typical shifts in pain, sleep, and performance.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

No anonymous side-effect reports yet. When reports are submitted, this panel will show a simple heatmap of tags like "nausea", "flushing", "improved healing", and more.

Research footprint

Last analyzed Jun 2, 2026

Studies indexed

Human

Animal

AI analyzed

Evidence mix0% human · 20% animal · 0% cellular · 0% review

Highest phase: PreclinicalYears covered: 2026

Librarian pulse — latest actionsFull changelog ↓

Jun 2, 5:00 PMRe-scoredScored effects for Melanotan II
Jun 1, 6:00 AMRefreshedRefreshed content for Melanotan II
May 31, 6:00 AMRefreshedRefreshed content for Melanotan II

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Melanotan II (Synthetic Cyclic Melanocortin Receptor Agonist) as an Adjunct to Narrowband UV-B Phototherapy in Adults With Stable Nonsegmental VitiligoClinical TrialClinicalTrials.govPublished Feb 2, 2026Added Apr 16, 2026

This study evaluated the effects of Melanotan II as an adjunct to narrowband UV-B phototherapy in adults with stable nonsegmental vitiligo. The study was a randomized, double-blind, placebo-controlled trial. No therapeutic claims are made in the abstract.

Phase: PHASE2Status: RECRUITING

Semantic Scholar search for Melanotan IIStudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Barbie drug identification: Not a child's play.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.StudyPubMedAdded Dec 12, 2025

The study explores the effects of Semax and Melanotan II on stress and mood in rats, but specific outcomes and implications for human health are not detailed.

Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

External databases

Helpful external resources for additional structural, pharmacologic, and literature context. These are third-party databases; always cross-check details with primary research.

Community notes

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Community research logs (detail)

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Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

Use the "Report side effects" button to open a focused popup form. Please keep descriptions neutral and avoid medical language; think in terms of "nausea", "flushing", "vivid dreams", etc.

Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

59m agoScoring70%

Scored effects for Melanotan II

1d agoRefreshai-researcher85%

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2d agoRefreshai-researcher85%

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3d agoRefreshai-researcher85%

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4d agoRefreshai-researcher85%

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6d agoRefreshai-researcher85%

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6d agoRefreshai-researcher85%

Refreshed content for Melanotan II

May 26Scoring70%

Scored effects for Melanotan II

May 26task_runlibrarian-runner

Completed task: Find real articles for Melanotan II (thin literature)

May 26Ingestiondiscovery

Searched for real articles on Melanotan II

Apr 20Refreshdiscovery50%

Refreshed content for Melanotan II

Apr 20SummarySemanticScholar0%

Auto-summarized study: "Semantic Scholar search for Melanotan II..."

Apr 17Refreshai-researcher85%

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Apr 16Refreshai-researcher85%

Refreshed content for Melanotan II