Correlation of the estimated glucose disposal rate with self-reported endometrial cancer: a cross-sectional study from NHANES 1999-2018.
Higher estimated glucose disposal rate is associated with lower odds of self-reported endometrial cancer, suggesting a potential link between insulin sensitivity and cancer risk.
Where it sits
this study against the rest of the mgf (mechano growth factor) corpusSummary and findings
This study evaluated the correlation between estimated glucose disposal rate (eGDR) and self-reported endometrial cancer (EC) in a cross-sectional sample of 31,666 female NHANES respondents from 1999-2018. The eGDR was significantly lower in the EC group compared to controls. The odds ratio for eGDR being inversely associated with self-reported EC was 0.906.
Abstract
Given accumulating data implicating insulin resistance (IR) in endometrial carcinogenesis, this study evaluated whether eGDR-a feasible non-invasive IR metric-is associated with self-reported endometrial cancer in a cross-sectional population-based sample. The analytical sample consisted of 31,666 female NHANES respondents (1999-2018), including 248 EC cases versus 31,418 cancer-free comparators. Propensity score matching (1:1) controlled for baseline imbalances. The eGDR was significantly lower in the EC group (6.84 ± 2.76) than in the control group (7.51 ± 2.66) (P = 0.004). After adjusting for confounding variables, the odds ratio (OR) for eGDR as a inversely associated with self-reported EC was 0.906 (95% CI: 0.826-0.991, P = 0.0328). A significant decreasing trend in EC risk was observed across eGDR quartiles. After covariate adjustment, eGDR remained inversely associated with EC (Model 2: OR 0.917, 95% CI 0.849-0.988, P = 0.024; Model 3: OR 0.906, 95% CI 0.826-0.991, P = 0.0328). Additionally, the restricted cubic spline revealed a significant nonlinear correlation between eGDR and the risk of EC. In this large cross-sectional study, higher eGDR was associated with lower odds of prevalent self-reported EC. These findings suggest a link between insulin sensitivity and endometrial cancer that warrants prospective evaluation.
Background
This paper addresses the potential link between insulin resistance and endometrial cancer, a topic of increasing interest due to the role of metabolic factors in cancer development. Prior studies have suggested that insulin sensitivity may influence cancer risk, but the specific relationship with endometrial cancer has not been extensively explored. This study is significant as it utilizes a large, population-based sample to investigate this association.
Methods
The study employed a cross-sectional design using data from 31,666 female NHANES respondents from 1999 to 2018, including 248 cases of self-reported endometrial cancer and 31,418 cancer-free comparators. Propensity score matching was used to control for baseline imbalances. The primary outcome measure was the estimated glucose disposal rate (eGDR), assessed through a non-invasive metric.
Results
The primary finding was that eGDR was significantly lower in the endometrial cancer group (6.84 ± 2.76) compared to the control group (7.51 ± 2.66), with a p-value of 0.004. The odds ratio for eGDR being inversely associated with self-reported endometrial cancer was 0.906 (95% CI: 0.826-0.991, P = 0.0328). Additional models confirmed this inverse association, with ORs of 0.917 and 0.906 after covariate adjustments.
Interpretation
These findings suggest a potential association between higher eGDR and lower odds of endometrial cancer, which aligns with existing literature on insulin sensitivity and cancer risk. However, the effect sizes, while statistically significant, may not be clinically meaningful due to the nature of the observational study. The cross-sectional design and reliance on self-reported data introduce confounding factors that limit the ability to draw definitive conclusions about causality.
Key findings
- eGDR in EC group was 6.84 ± 2.76 compared to 7.51 ± 2.66 in the control group (P = 0.004)
- Odds ratio (OR) for eGDR inversely associated with self-reported EC was 0.906 (95% CI: 0.826-0.991, P = 0.0328)
- After covariate adjustment, OR for eGDR in Model 2 was 0.917 (95% CI 0.849-0.988, P = 0.024)
- After covariate adjustment, OR for eGDR in Model 3 was 0.906 (95% CI 0.826-0.991, P = 0.0328)
- A significant decreasing trend in EC risk was observed across eGDR quartiles
Limitations
- cross-sectional design limits causal inference
- self-reported data may introduce bias
- small number of endometrial cancer cases (n=248)
- observational study, potential confounding factors